Aspects of the use of injectable antibiotics, isolation frequency of bacteria and frequencies of drug-resistant strains in some bacteria in Tatebayashi Kosei Hospital during a recent three-year period were studied. In 1982, 1983 and 1984, the yearly amount of antibiotic consumption was 85, 000 ; 73, 000 and 69, 000 ampules and vials and 91, 80 and 73 kilograms, respectively. During the three years, cephems (61-63%) and penicillins (20-21%) were the most frequently used, followed by aminoglycosides (10-12%) and fosfomycin (3-4%). The consumption of chloramphenicol, erythromycin, doxycycline and lincomycin was markedly lower. There was a decrease in the isolation frequency of bacteria in 1984 when compared with that of in 1982 and 1983. Approximately 70% of the bacteria isolated from clinical specimens were gram-negative bacilli. From 1982 through 1984, the frequencies of ampicillin-resistant S. aureus, cefazolin-resistant E. coli, sulbenicillin-resistant Ps. aeruginosa and cefotaxime-resistant Serratia were 13-17%, 1-3%, 47-52% and 1-3%, respectively.
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