In vitro uptake of tritiated thymidine in slices of human breast tumor tissues was studied by autoradiographic technique. Labeling index was determined as number of labelled cells/ 100 cells. The examined cases were 29 normal breasts, one pregnant breast, 4 lactating breasts, 25 mastopathic breasts, 8 fibroadenomas, 6 giant fibroadenomas and 38 carcinomas.
In normal duct epithelum, the labeling indices varied widely from 0.1% to 9.0% and mean labeling index was 2.7%, whereas the labeling index of atrophic duct epithelium was appearently low. The labeling index of breast tissue in pregnancy was 7.4%, and this value was comparable to the highest value in normal breast tissues. The labeling index of breast tissue in lactation was relatively low. The labeling indices of normal breast tissues related to age showed the peak on the group of 30 to 39 years of age, therefore, that pattern seemed to be proportional to endocrine maturity.
The mean labeling index of mastopathic breast was somewhat lower than that of normal breast tissue. According to the histological patterns of mastopathy, the mean labeling index was 2.2% in blunt duct adenosis, 0.7% in duct papillomatosis, 0.6% in sclerosing adenosis and 0.1% in apocrine metaplasia, respectively.
The mean labeling index of fibroadenoma was 3.1% and the value was lower than that of carcinoma, but higher than that of normal breast tissue. The labeling index of epithelial cells in giant fibroadenoma was higher than that in normal breast. The labeling in stromal cells was also highly noted, unlikely in other breast tissues.
The labeling indices in breast carcinoma tissue were distributed as widely as those in normal breast tissues. The mean labeling index of carcinoma was higher than that of normal breast tissue. According to the histological pattern of carcinoma, the labeling index in papillotubular carcinoma was some what lower than those of the cases with other histological patterns. The labeling in breast carcinoma in early stage was lower than that of carcinoma in advanced stage on respects of tumor size and involved lymphnodes.
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