Neurologia medico-chirurgica
Online ISSN : 1349-8029
Print ISSN : 0470-8105
ISSN-L : 0470-8105
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Volume 33, Issue 11
Displaying 1-10 of 10 articles from this issue
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  • Enhanced Secretion of Endothelin by Endothelial Cells in Response to Hemoglobin
    Isao FUWA, Marc MAYBERG, Corinne GADJUSEK, Tsutomu HARADA, Zhengyu LUO
    1993 Volume 33 Issue 11 Pages 739-743
    Published: 1993
    Released on J-STAGE: June 20, 2006
    DOIhttps://doi.org/10.2176/nmc.33.739
    JOURNAL FREE ACCESS
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    Confluent cultures of bovine aortic endothelium in serum-free medium were exposed to increasing concentrations (10-6-10-4 M) of freshly prepared erythrocyte lysates (primarily hemoglobin). Hemoglobin increased endothelin-1 secretion into the medium in a dose-dependent manner after 24 hours. The enhanced secretion of endothelin-1 in response to hemoglobin was sustained for 72 hours, suggesting active production and secretion of endothelin-1 rather than release from intracellular pools. Secreted endothelin-1 in the medium was characterized by high-performance liquid chromatography coupled with radioimmunoassay. Endothelin-1, a potent and long-lasting vasoconstrictor, may be one of the causative factors of cerebral vasospasm after subarachnoid hemorrhage. Oxyhemoglobin, derived from periarterial clot, may play an important role in the secretion of endothelin-1 in cerebral vasospasm.
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  • Effects of Irradiation on Cytokine Production in Glioma Cell Lines
    Ryuya YAMANAKA, Ryuichi TANAKA, Seiichi YOSHIDA
    1993 Volume 33 Issue 11 Pages 744-748
    Published: 1993
    Released on J-STAGE: June 20, 2006
    DOIhttps://doi.org/10.2176/nmc.33.744
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    The effects of irradiation on cytokine production in glioma cell lines, NP1, NP2 and NP3, were studied. Culture supernatants were collected after 6, 24, 48 or 72 hours and the concentrations of interleukin (IL)-6 and IL-8 measured by enzyme-linked immunosorbent assay. Spontaneous and IL-1β-stimulated productions were analyzed. Some cells were given a single dose of Lineac irradiation (10 or 20 Gy).
     Production of IL-6 (with or without IL-1β stimulation) increased gradually to a maximum after 72 hours, more in the 20 Gy-irradiated cells than 10 Gy cells (p < 0.01). Production of IL-8 increased gradually to a maximum after 48 or 72 hours. Spontaneous production of IL-8 increased more in 20 Gy-irradiated cells than 10 Gy cells after 6 and 24 hours (p < 0.01), but increased more in 10 Gy cells than 20 Gy cells after 48 and 72 hours (p < 0.01). The production of IL-8 stimulated by IL-1β increased more in 10 Gy cells than 20 Gy cells 24 hours later (p < 0.01). IL-6 and IL-8 production differed in the response to irradiation. Our data suggest that bidirectional communication between the immune system and glioma cells changes after radiotherapy.
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  • Effects of Irradiation on the Expression of the Adhesion Molecules (NCAM, ICAM-1) by Glioma Cell Lines
    Ryuya YAMANAKA, Ryuichi TANAKA, Seiichi YOSHIDA
    1993 Volume 33 Issue 11 Pages 749-752
    Published: 1993
    Released on J-STAGE: June 20, 2006
    DOIhttps://doi.org/10.2176/nmc.33.749
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    The expression of the intercellular adhesion molecule 1 (ICAM-1) and neural cell adhesion molecule (NCAM) by glioma cell lines was investigated. The effects of interferon (IFN)-γ or irradiation on the expression was also assessed. Two glioma cell lines showed more than 75% NCAM-positive cells. After treatment with IFN-γ or irradiation, another three cell lines were induced to show more than 50% positive cells. Three glioma cell lines showed more than 50% ICAM-1-positive cells. After treatment with IFN-γ, another two cell lines were induced to show more than 50% positive cells. After treatment with irradiation, one more cell line was induced to show more than 50% positive cells. ICAM-1 and NCAM expression by glioma cell lines is susceptible to modulation by IFN-γ or irradiation.
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  • Hemodynamic Study on Flow Patterns in the Carotid Bifurcation Before and After Carotid Endarterectomy Using Cine Magnetic Resonance Imaging
    Kanji YAMANE, Takeshi SHIMA, Yoshikazu OKADA, Masahiro NISHIDA, Shinji ...
    1993 Volume 33 Issue 11 Pages 753-757
    Published: 1993
    Released on J-STAGE: June 20, 2006
    DOIhttps://doi.org/10.2176/nmc.33.753
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    Blood flow in the cervical carotid bifurcation was investigated by cine magnetic resonance imaging. In patients without stenosis, a low-intensity stream was demonstrated from the beginning of the carotid bulb, which was more distinct in the systolic phase. In patients with stenotic carotid bifurcations, the low-intensity flow was also present but was more prominent than in the non-stenotic bifurcation. This low-intensity stream may be due to the change from steady to turbulent flow due to the geometric characteristics of the carotid bifurcation or atheromatous plaque, similar to the flow separation phenomenon in fluid dynamics because of the coincidence of location and flow pattern. After carotid endarterectomy, turbulent flow was seen at the proximal and distal ends of the endarterectomy. Close follow-up and administration of antiplatelet agents are necessary to prevent restenosis due to mural thrombosis induced by such turbulent flow.
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  • Magnetic Resonance Angiography of Arteriovenous Malformation in the Brainstem
    Hirofumi OYAMA, Yoshihisa KIDA, Tatsuya KOBAYASHI, Takayuki TANAKA, Ta ...
    1993 Volume 33 Issue 11 Pages 758-761
    Published: 1993
    Released on J-STAGE: June 20, 2006
    DOIhttps://doi.org/10.2176/nmc.33.758
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    The magnetic resonance (MR) angiography appearance of arteriovenous malformation (AVM) in the tegmentum and pons is described. The interpeduncular perforating branches of the posterior cerebral artery and median pontine branches of the basilar artery were seen more clearly by MR angiography than by conventional angiography. MR angiography was very useful for the follow-up of AVM after stereotactic radiosurgery.
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  • Magnetic Resonance Angiography of Arteriovenous Malformation in the Thalamus
    Hirofumi OYAMA, Yoshihisa KIDA, Tatsuya KOBAYASHI, Takayuki TANAKA, Ta ...
    1993 Volume 33 Issue 11 Pages 762-764
    Published: 1993
    Released on J-STAGE: June 20, 2006
    DOIhttps://doi.org/10.2176/nmc.33.762
    JOURNAL FREE ACCESS
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    A comparative study of magnetic resonance angiography and conventional angiography of arteriovenous malformation in the thalamus showed that both methods clearly visualized the feeding arteries: perforating branches of the posterior cerebral artery, posterior choroidal artery and lenticulostriate artery. Draining veins such as the internal cerebral vein were also demonstrated well.
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  • Vertebral Artery Dissecting Aneurysm Rebleeding After Proximal Occlusion —Case Report—
    Nobuyuki TAKAI, Isamu EZUKA, Takatoshi SORIMACHI, Takashi KUMAGAI, Kat ...
    1993 Volume 33 Issue 11 Pages 765-768
    Published: 1993
    Released on J-STAGE: June 20, 2006
    DOIhttps://doi.org/10.2176/nmc.33.765
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    A 38-year-old male presented with vertebral artery dissecting aneurysm manifesting as subarachnoid hemorrhage. An attempt at trapping the aneurysm failed, so the vertebral artery could only be clipped proximally. Rebleeding occurred, resulting in death, probably due to excessive length of the dissection requiring thrombosis and/or retrograde dissection due to back pressure from the contralateral vertebral artery.
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  • Bilateral Vertebral Artery Occlusion Secondary to Atlantoaxial Dislocation with Os Odontoideum: Implication for Prophylactic Cervical Stabilization by Fusion —Case Report—
    Kenji KIKUCHI, Hiroshi NAKAGAWA, Kazuo WATANABE, Masayoshi KOWADA
    1993 Volume 33 Issue 11 Pages 769-773
    Published: 1993
    Released on J-STAGE: June 20, 2006
    DOIhttps://doi.org/10.2176/nmc.33.769
    JOURNAL FREE ACCESS
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    A 27-year-old male presented with an unusual atlantoaxial dislocation associated with os odontoideum, after suffering sudden onset of significant neurological deterioration. Angiography demonstrated simultaneous occlusion of the bilateral vertebral arteries assumed responsible for the devastating neurological deficits. He initially underwent cervical immobilization with a Crutchfield tong for 2 months and subsequent posterior fusion using an iliac bone graft and wires. The neurological symptoms gradually subsided, and 5 years later good healing of the bone graft without instability and ample subarachnoid space around the spinal cord were radiologically confirmed. Early prophylactic stabilization of atlantoaxial dislocation due to os odontoideum is recommended to prevent a poor outcome. Careful angiographic evaluation of the vertebrobasilar circulation is important for management of patients with os odontoideum.
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  • Use of STA-MCA Anastomosis for Clipping of Giant Middle Cerebral Artery Aneurysm —Case Report—
    Masato KIMURA, Akira TANAKA, Haruo MATSUNO, Shinji NAGATA
    1993 Volume 33 Issue 11 Pages 774-778
    Published: 1993
    Released on J-STAGE: June 20, 2006
    DOIhttps://doi.org/10.2176/nmc.33.774
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    A 50-year-old female developed subarachnoid hemorrhage due to rupture of a giant aneurysm in the left middle cerebral artery (MCA). One month later, direct surgery was performed on the aneurysm. The superficial temporal artery was anastomosed to the cortical artery of the parietal MCA segment. The MCA was exposed and trapped for 40 minutes during barbiturate infusion, with electroencephalographic and somatosensory evoked potential monitoring. During MCA trapping, the aneurysm was collapsed by dome puncture and obliterated by neck clipping. After surgery, she had only mild amnestic aphasia and an infarct in the medial temporal lobe demonstrated by computed tomography. However, cerebral angiography disclosed complete occlusion of the MCA by the displaced aneurysm clip, and perfusion of the distal MCA segments through the anastomosis. The initial bypass procedure prevented a disastrous outcome in this patient and is recommended for direct surgery on MCA aneurysms.
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  • Basal Ganglia Germinoma with Crossed Cerebellar Diaschisis —Case Report—
    Yukihiro TSUCHIDA, Koji TSUBOI, Kiyoyuki YANAKA, Tadao NOSE
    1993 Volume 33 Issue 11 Pages 779-782
    Published: 1993
    Released on J-STAGE: June 20, 2006
    DOIhttps://doi.org/10.2176/nmc.33.779
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    An 8-year-old boy presented with a germinoma of the right basal ganglia manifesting as gradual onset of mild left hemiparesis. Computed tomography (CT) and magnetic resonance imaging disclosed a mass lesion in the right basal ganglia with mild right cerebral hemiatrophy. Single photon emission CT revealed decreased cerebral blood flow in both the right cerebral and left cerebellar hemispheres, or crossed cerebellar diaschisis. The histology of a specimen from a stereotactic needle biopsy was compatible with two-cell pattern germinoma. After irradiation and chemotherapy, the mass lesion disappeared completely. The clinical symptoms and crossed cerebellar diaschisis gradually improved.
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