Neurologia medico-chirurgica
Online ISSN : 1349-8029
Print ISSN : 0470-8105
ISSN-L : 0470-8105
Volume 33, Issue 7
Displaying 1-10 of 10 articles from this issue
  • Akihiro TAKAHASHI, Kazuo ITOH, Eriko TSUKAMOTO, Masayori FURUDATE, Hir ...
    1993 Volume 33 Issue 7 Pages 415-419
    Published: 1993
    Released on J-STAGE: June 20, 2006
    JOURNAL FREE ACCESS
    Tissue-type plasminogen activator (t-PA) effectively lyses active thrombus by direct action. Recombinant t-PA (rt-PA) was labeled with technetium-99m (99mTc) to investigate the in vivo binding to fibrin clots in a feline cerebral embolism model created by insertion of an artificial fibrin clot within the carotid artery. 99mTc-rt-PA administered intravenously provided clearer imaging of clots after priming with cold rt-PA, with uptake peaking 5-10 minutes after the injection. 99mTc-labeled human serum albumin was not retained at clot sites. Systemically administered 99mTc-rt-PA binds to fibrin clots within carotid arteries in our feline model. Our results suggest that the interaction of intrinsic plasminogen activator inhibitors with extrinsically administered rt-PA may regulate the demonstration of a clot, although the precise mechanism is unclear.
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  • Junichi MIZUNO, Kinjiro IWATA, Yoshio TAKEI
    1993 Volume 33 Issue 7 Pages 420-424
    Published: 1993
    Released on J-STAGE: June 20, 2006
    JOURNAL FREE ACCESS
    The cytogenesis of so-called hemangioblastoma arising in the central nervous system was investigated using the immunoreactivity to various proteins in cerebellar hemangioblastomas, extracerebellar hemangioblastomas, cerebral hemangiopericytomas, and hemangioendotheliomas, as well as a variety of meningiomas. The antisera used included vimentin, glial fibrillary acidic protein, epithelial membrane antigen, factor VIII-related antigen, and cytokeratin. Lipid-laden cells often encountered in partially degenerated meningiomas revealed almost identical reactivity patterns as the lipid-laden cells, i.e., so-called stroma cells, of hemangioblastomas. The results indicate that the so-called hemangioblastoma of the central nervous system is derived from arachnoid cells in meningotheliomatous meningiomas by way of cellular degeneration.
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  • Masaru TAMURA, Nobuo ONO, Akira ZAMA, Shogo ISHIUCHI, Yasuhiro KAWASHI ...
    1993 Volume 33 Issue 7 Pages 425-428
    Published: 1993
    Released on J-STAGE: June 20, 2006
    JOURNAL FREE ACCESS
    The clinicopathological characteristics of small gliomas were investigated in nine patients with gliomas less than 2 cm in diameter. The tumor histology and proliferative activity were also examined. Three tumors occurred in the white matter and six at the corticomedullary junction. Histological diagnosis, Daumas-Duport''s grading, bromodeoxyuridine labeling index, and proliferating cell nuclear antigen counts were well correlated. Most small gliomas were histologically benign, localized, and removable if not in eloquent areas of the brain. However, some cases showed high-grade glioma and invasive character at the early stage, resulting in a poor outcome.
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  • Keiichi SAKAI, Tsuyoshi TADA, Kazuaki FUKASAKU, Kazuhiko KYOSHIMA, Shi ...
    1993 Volume 33 Issue 7 Pages 429-433
    Published: 1993
    Released on J-STAGE: June 20, 2006
    JOURNAL FREE ACCESS
    Magnetic resonance imaging often demonstrates gadolinium (Gd) enhancement of the dura mater around meningiomas. The Gd-enhanced dura mater was histologically investigated to detect meningioma cells. Gd enhancement of the dura mater occurred in 11 (79%) of the 14 meningiomas studied, and extended as far as 35 mm from the tumor. Histological examination revealed generation of vascular-rich loose connective tissue at the surface of the dura in all five tumors examined. Some clusters of meningothelial cells were distributed in the loose connective tissue in three of the five specimens, and one cluster was obviously neoplastic. These observations suggest that clusters of meningioma cells occur in the Gd-enhanced dura mater around meningiomas.
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  • Satoshi KURODA, Hiroyasu KAMIYAMA, Hiroshi ABE, Toru YAMAUCHI, Yoshihi ...
    1993 Volume 33 Issue 7 Pages 434-438
    Published: 1993
    Released on J-STAGE: June 20, 2006
    JOURNAL FREE ACCESS
    Changes in the mean cerebral blood flow (mCBF) with growth in normal children (1-20 years old) were evaluated, and compared to serial mCBF changes in children with spontaneous occlusion of the circle of Willis (moyamoya disease) after vascular reconstructive surgery. mCBF gradually decreased with growth in control children. Preoperative mCBF was similar or decreased in moyamoya disease patients with transient ischemic attack, and slightly decreased in those with cerebral infarction. Postoperative mCBF gradually decreased similarly to physiological changes with growth in controls. These results suggest that changes with age should be considered when preoperative and long-term cerebral hemodynamics are evaluated in children with moyamoya disease.
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  • Kiyoyuki YANAKA, Shizuo SHIRAI, Yasushi SHIBATA, Takao KAMEZAKI, Akira ...
    1993 Volume 33 Issue 7 Pages 439-443
    Published: 1993
    Released on J-STAGE: June 20, 2006
    JOURNAL FREE ACCESS
    The utility of gadolinium (Gd)-enhanced magnetic resonance (MR) angiography in the planning of supratentorial glioma surgery was evaluated. MR angiograms of the arterial and venous anatomy visualized the anatomical relationship of the main arteries to the tumor, especially on three-dimensional images. Combination with data from surface anatomical images allowed the tumor location to be determined preoperatively. Gd-enhanced MR angiography can be used non-invasively prior to tumor surgery to ascertain the spatial relationship of the vessels to the tumor mass.
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  • Yoshimi MATSUOKA, Katsuhisa KAWAJIRI, Koji HAYAZAKI, Akira HAKUBA
    1993 Volume 33 Issue 7 Pages 444-447
    Published: 1993
    Released on J-STAGE: June 20, 2006
    JOURNAL FREE ACCESS
    A simple technique to place an atrial catheter for ventriculo-atrial shunt has been developed. The subclavian vein is punctured percutaneously from the direction between the clavicle and the first rib by the same procedure used for central venous catheterization using the introducer designed for Fr. 7 catheter. The position of the tip of the catheter is determined by x-ray fluoroscopy. The technique was found to be simple, safe, and timesaving in two patients.
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  • Yukihiro IBAYASHI, Toshiaki YAMAKI, Takahisa KAWAHARA, Masahiko DAIBO, ...
    1993 Volume 33 Issue 7 Pages 448-457
    Published: 1993
    Released on J-STAGE: June 20, 2006
    JOURNAL FREE ACCESS
    Nine patients with malignant brain tumors were treated with intratumoral infusion of lymphokine-activated killer (LAK) cells and interleukin-2 (IL-2). LAK cells were generated from macrophagedepleted peripheral blood lymphocytes by culturing with IL-2 for 4 days. The resulting LAK cells showed strong cytotoxic activity against tumor target cells. Three patients received sufficient LAK cells (≥ 5.76 × 108) to show partial tumor response by computed tomography and clinical signs. No severe neurological side effects occurred in any patient. Intratumoral administration of LAK cells and IL-2 can be effective in patients with malignant brain tumors.
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  • Toshiaki FUJITA, Hidemitsu NAKAGAWA, Koichiro TSURUZONO, Shuichi IZUMO ...
    1993 Volume 33 Issue 7 Pages 458-462
    Published: 1993
    Released on J-STAGE: June 20, 2006
    JOURNAL FREE ACCESS
    A 42-year-old male presented with a rare extracranial meningioma manifesting as right facial swelling, facial nerve paresis, and hearing disturbance. Neurological imaging revealed a primarily extra-axial tumor extending from the temporal base to the subcutaneous space in the parietal region, and partially into the intra-axial region of the temporal lobe through the dura mater, with a small intracerebral hematoma and a small mass in the porus acusticus destroying the temporal bone, the floor of the middle fossa, zygomatic arch, and porus acusticus. Malignant meningioma was confirmed by histological examination after subtotal tumor removal via the transzygomatic approach. Subdural fluid accumulation like hematoma occurred 5 days after surgery and malignant cells were found in the fluid drained by skull trephination. Subsequently, radiation therapy with a total dose of 60 Gy was administered. One year later, he complained of head and neck pain with motor and sensory disturbances in the right upper extremity, and then developed tetraparesis. Cervical x-ray films demonstrated a compression fracture of the C3 vertebral bone and radiolucent areas at C2-4 levels, while computed tomography showed the tumor invading the subcutaneous space and compressing the spinal cord. He died of respiratory distress. Autopsy revealed that the tumor originated in the temporal region and had directly extended to the cervical region.
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  • Toshimitsu AIDA, Hiroshi ABE, Terufumi ITOH, Kazuo NAGASHIMA, Kazuaki ...
    1993 Volume 33 Issue 7 Pages 463-466
    Published: 1993
    Released on J-STAGE: June 20, 2006
    JOURNAL FREE ACCESS
    A desmoplastic infantile ganglioglioma occurred in a 5-month-old boy, manifesting as delayed psychomotor development. Computed tomography showed a large cystic mass involving the left occipitoparietal lobes. The tumor was totally removed. He has survived for 13 years without tumor recurrence. Histological examination disclosed marked desmoplasia intermixed with mature-looking ganglion cells, neoplastic glial cells, and small, immature round cells. These clinical and histological features enabled the diagnosis of desmoplastic infantile ganglioglioma.
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