Neurologia medico-chirurgica

Ultrastructural Immunocytochemistry of Tetanus Toxin Binding Sites to Spinal Ganglia of Chick Embryo in Tissue Culture

Sohji SHINODA, Toshio MASUZAWA, Fumiaki SATO

1984 Volume 24 Issue 1 Pages 1-4
Published: 1984
Released on J-STAGE: September 21, 2006

DOIhttps://doi.org/10.2176/nmc.24.1

JOURNAL FREE ACCESS

Show abstractHide abstract

By the use of immunoperoxidase technique, tetanus toxin binding sites were ultrastructurally demonstrated in monolayer culture after three days in cultures derived from the spinal ganglia of the 10 daychick embryo. The toxin binding sites, seen as electron dense reaction products, were clearly limited to the surface membranes of the neuronal processes, but not of the nerve cell bodies.

View full abstract

Download PDF (496K)
The Effect of Indomethacin on Ischemic Brain Edema

—A Study Using Cat Middle Cerebral Artery Occlusion Combined with Recirculation—

Tohru MATSUI, Norihiko BASUGI, Takao ASANO, Kintomo TAKAKURA

1984 Volume 24 Issue 1 Pages 5-12
Published: 1984
Released on J-STAGE: September 21, 2006

DOIhttps://doi.org/10.2176/nmc.24.5

JOURNAL FREE ACCESS

Show abstractHide abstract

The role of the arachidonate cascade in the development of ischemic edema was studied using indomethacin, an inhibitor of cyclooxygenase. Cortical specific gravity (SG) was measured in cats after middle cerebral artery (MCA) occlusion.
The cats were divided into five groups: Groups 1 and 2—two and four hour MCA occlusion; Group 3—two hour MCA occlusion followed by two hour MCA recirculation; Group 4—two hour MCA occlusion followed by two hour MCA recirculation with preadministration of indomethacin (4 mgkg, i.v.); and Group 5—four hour MCA occlusion with indomethacin. The local cerebral blood flow (1CBF) was measured periodically with cortical electrodes by the hydrogen clearance method. At the end of the experiment, .the SG of the cerebral cortex surrounding each electrode was measured using a gradient column. Indomethacin caused a generalized 1CBF reduction of about 16%. During occlusion as well as recirculation, however, there was no significant difference in 1CBF between the indomethacintreated and -untreated groups. A significant reduction in the SG was observed in all groups accompanying profound ischemia (1CBF less than 20 ml100 gmin). Compared with continuous MCA occlusion (Groups 1 and 2), recirculation resulted in further reduction in the cortical SG (Group 3). This recirculation-induced reduction in the SG was almost completely prevented by the indomethacin pretreatment (Group 4). In Group 5, indomethacin further reduced the cortical SG. The above results indicate that the arachidonate cascade is involved in the aggravation of cerebral edema following the onset of recirculation.

View full abstract

Download PDF (542K)
Astroprotein (GFAP) Levels in Cerebrospinal Fluid of Stroke Patients

Toru HAYAKAWA, Yukitaka USHIO, Yasutaka MAEDA, Norio ARITA, Toshiki YO ...

1984 Volume 24 Issue 1 Pages 13-18
Published: 1984
Released on J-STAGE: September 21, 2006

DOIhttps://doi.org/10.2176/nmc.24.13

JOURNAL FREE ACCESS

Show abstractHide abstract

Radioimmunoassay was employed to study the astroprotein (Ap)—an astrocyte-specific cerebroprotein which is immunologically identical to glial fibrillary acidic protein (GFAP)—levels in the cerebrospinal fluid (CSF) of stroke patients in the acute or subacute stage. These levels tended to increase in the acute stage, especially in cases with intracerebral hemorrhage. The increases were related to the size of the lesion and the patients' general neurological state. The post-ictal increases were more rapid in cases with intracerebral hemorrhage than with cerebral infarction; both exhibited a correlation between the CSF-Ap levels in the acute stage and the prognosis.

View full abstract

Download PDF (317K)
Multimodality Treatment of Malignant Glioma

—Effect of Chemotherapy with ACNU and Immunotherapy with N-CWS—

Jun YOSHIDA, Tatsuya KOBAYASHI, Naoki KAGEYAMA

1984 Volume 24 Issue 1 Pages 19-26
Published: 1984
Released on J-STAGE: September 21, 2006

DOIhttps://doi.org/10.2176/nmc.24.19

JOURNAL FREE ACCESS

Show abstractHide abstract

Sixty-nine patients with malignant glioma received multimodality adjuvant therapy postoperatively. The patients were divided into three treatment groups. Group A (n=21) was treated with radiochemotherapy, Group B (n=21) with radiochemoimmunotherapy, and Group C (n=27) with radiotherapy alone. The effectiveness of each adjuvant mode of therapy was statistically compared in terms of the objective regression of the tumor and by survival curves. The results of this study indicate the importance of chemotherapy with ACNU and immunotherapy with N-CWS in the treatment of malignant gliomas.

View full abstract

Download PDF (508K)
Intracerebral Hemorrhage Immediately Following Surgical Treatment of Chronic Subdural Hematoma

—Report of Two Cases—

Noboru NAKAHARA, Toshio MASUZAWA, Koichi KUNO, Fumiaki SATO

1984 Volume 24 Issue 1 Pages 27-29
Published: 1984
Released on J-STAGE: September 21, 2006

DOIhttps://doi.org/10.2176/nmc.24.27

JOURNAL FREE ACCESS

Show abstractHide abstract

Two rare cases of intracerebral hematoma which were encountered immediately after the surgical treatment of an intracranial chronic subdural hematoma were reported. In Case 1, a 70-year-old man deteriorated immediately following the irrigation of a chronic subdural hematoma. The carotid angiogram obtained two hours after the operation revealed a subcortical hemorrhage beneath the previously operated area, and this intracerebral hematoma was verified by the second operation four hours after the first. In Case 2, a 78-year-old woman immediately developed complete left hemiplegia and a drowsy state after removal of chronic subdural hematoma by craniotomy. About twenty hours after the operation, a follow-up CT scan revealed an intracerebral hematoma just beneath the previously removed hematoma in the right temporo-parietal lobe.
Based on these experiences, although rare, the development of an intracerebral hemorrhage must be considered if a patient deteriorates immediately following surgical treatment of a chronic subdural hematoma. The possible reasons for the appearance of such intracerebral hematomas were also discussed.

View full abstract

Download PDF (291K)
Unilateral Moyamoya Disease Associated with Multiple Aneurysms

—A Case Report and Review of the Literature—

Shizuya KASAMO, Tetsuhiko ASAKURA, Yukio YAMAMOTO, Eiki KOBAYASHI

1984 Volume 24 Issue 1 Pages 30-34
Published: 1984
Released on J-STAGE: September 21, 2006

DOIhttps://doi.org/10.2176/nmc.24.30

JOURNAL FREE ACCESS

Show abstractHide abstract

A case of unilateral moyamoya disease associated with multiple aneurysms arising from the anterior communicating artery and peripheral portion of the dilated anterior choroidal artery was presented. The literature on the mechanism of the formation of aneurysm in moyamoya disease was briefly reviewed.

View full abstract

Download PDF (450K)
An Autopsy Case of Cerebellar Hemorrhagic Infarction in the Region of the Bilateral Superior Cerebellar Arteries

Tetsumori YAMASHIMA, Masahiko KAWABATA

1984 Volume 24 Issue 1 Pages 35-38
Published: 1984
Released on J-STAGE: September 21, 2006

DOIhttps://doi.org/10.2176/nmc.24.35

JOURNAL FREE ACCESS

Show abstractHide abstract

The authors describe an autopsy case of cerebellar hemorrhagic infarction in the region of the bilateral superior cerebellar arteries (SCA). A 79-year-old woman suddenly developed dysarthria, bilateral blepharoptosis, external ophthalmoplegia, left hemiparesis, dysphagia and dysuria. CT scan revealed low density in the bilateral cerebellar hemispheres. Angiography revealed narrowing of the distal portion of the basilar artery. The patient made a gradual recovery in the first two weeks, but she died of a hyperglycemic non-ketotic diabetic coma on the 32nd day. Autopsy disclosed recent hemorrhagic infarctions of the bilateral SCA regions and of right Ammon's horn and numerous softenings of the brain stem, together with an old cystic infarction in the region of the middle cerebral artery. There were no occlusions in either the basilar or superior cerebellar arteries. It was suggested that an embolization due to severe atherosclerosis of the distal portion of basilar artery affected its pontine branches and bilateral SCA.

View full abstract

Download PDF (518K)
Cerebral Venous Angioma

—Case Report—

Shizuo HATASHITA, Saiken HATA, Kiyoshi SATO, Shozo ISHII

1984 Volume 24 Issue 1 Pages 39-41
Published: 1984
Released on J-STAGE: September 21, 2006

DOIhttps://doi.org/10.2176/nmc.24.39

JOURNAL FREE ACCESS

Show abstractHide abstract

A case of venous angioma in the right frontal lobe was presented. The patient was diagnosed by cerebral angiography and computed tomography, and verified pathologically at surgery. The surgical treatment was briefly discussed.

View full abstract

Download PDF (454K)
Tension Pneumocephalus as a Complication of a Ventriculoperitoneal Shunt

—Case Report—

Soichi SUNADA, Akira YAMAURA, Yasuyuki HOSAKA, Akimasa UOZUMI, Hiroyas ...

1984 Volume 24 Issue 1 Pages 42-45
Published: 1984
Released on J-STAGE: September 21, 2006

DOIhttps://doi.org/10.2176/nmc.24.42

JOURNAL FREE ACCESS

Show abstractHide abstract

A 15-year-old boy was admitted with complaint of headache two months after a ventriculoperitoneal shunt for hydrocephalus secondary to aqueductal stenosis. Examinations revealed massive pneumocephalus. The shunt valve was replaced to the one with antisiphon function, resulting in successful control of hydrocephalus and absorption of intracranial air collection. There have been only five reports of pneumocephalus as a complication of shunt operation in the literature. In our case there was no intraventricular air collection.

View full abstract

Download PDF (309K)
Gas-producing Brain Abscess due to Peptostreptococcus

Genya ODAKE

1984 Volume 24 Issue 1 Pages 46-50
Published: 1984
Released on J-STAGE: September 21, 2006

DOIhttps://doi.org/10.2176/nmc.24.46

JOURNAL FREE ACCESS

Show abstractHide abstract

A case of anaerobic streptococcus brain abscess was reported in which the cerebral lesion appeared on CT as a ring-enhanced mass, and gas bubbles were seen following corticosteroid administration without antibiotics. Surgery revealed no encapsulation. Surgical drainage of the cavity and treatment with antibiotics and corticosteroid were ineffective. Excision of the abscess and treatment with chloramphenical and glycerol were successful.

View full abstract

Download PDF (465K)
Intracranial Teratoma with a Prominent Rhabdomyogenic Element and Germinoma in the Fourth Ventricle

Isao IWASAKI, Hiroshi HORIE, Ten Jun YU, Yoshihiko KOKUBO, Makoto KATO ...

1984 Volume 24 Issue 1 Pages 51-55
Published: 1984
Released on J-STAGE: September 21, 2006

DOIhttps://doi.org/10.2176/nmc.24.51

JOURNAL FREE ACCESS

Show abstractHide abstract

Intracranial teratomas are relatively uncommon and most of them are found in the pineal or the parapineal regions. Germinomas are the most common histological type of intracranial germ cell tumors. A fourth ventricular tumor composed of a teratoma with an overgrowth of striated muscle tissue and germinoma in a 12-year-old girl is reported. It is suggested that primary intracranial rhabdomyosarcomas are closely related to a teratoid origin.

View full abstract

Download PDF (493K)

Register with J-STAGE for free!