Neurologia medico-chirurgica
Online ISSN : 1349-8029
Print ISSN : 0470-8105
ISSN-L : 0470-8105
Volume 35, Issue 4
Displaying 1-10 of 10 articles from this issue
  • Koh YANO, Hiroyuki KANOH, Toshihiko NAKASHIMA, Noboru SAKAI, Hiromu YA ...
    1995 Volume 35 Issue 4 Pages 205-208
    Published: 1995
    Released on J-STAGE: March 30, 2006
    JOURNAL FREE ACCESS
    The effect of transferrin on phosphoinositide metabolism was investigated in smooth muscle cells isolated from the porcine basilar artery. Ferric iron-bound transferrin induced a rapid increase in the level of inositol phosphates, the metabolic products of phosphoinositides through the phospholipase C pathway. Neither transferrin free of ferric iron nor ferric iron alone caused the activation of phospholipase C. This study suggests that ferric iron-bound transferrin is capable of eliciting receptormediated signal transduction in porcine cerebral arterial smooth muscle cells, which could result in the contraction of smooth muscle cells. Transferrin may be involved with the cerebral arterial narrowing in pathological conditions such as subarachnoid hemorrhage.
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  • Hirohito NIIDA, Shigekazu TAKEUCHI, Ryuichi TANAKA, Takashi MINAKAWA
    1995 Volume 35 Issue 4 Pages 209-214
    Published: 1995
    Released on J-STAGE: March 30, 2006
    JOURNAL FREE ACCESS
    Neovascularization is a prerequisite for glioma growth, so inhibition of angiogenesis may achieve control of glioma growth. We examined whether glioma cells induce angiogenesis and proliferation in microvascular endothelial cells from Fisher 344 rat brains by co-culture in a physical separation system with rat C6 glioma cells or rat T9 gliosarcoma cells. Endothelial cells cultured on type 1 collagen formed capillary-like structures. C6 glioma cells co-cultured with endothelial cells promoted the formation of these capillary-like structures. However, conditioned medium from C6 cells inhibited the proliferation of endothelial cells. T9 cells had little effect on the formation of capillary-like structures and no effect on the proliferation of endothelial cells. We also examined the effects of human tumor necrosis factor (TNF)-α on the formation of the capillary-like structures and on the proliferation of endothelial cells. Human TNF-α inhibited the formation of capillary-like structures induced by C6 glioma cells at a concentration of 100 U/ml, as well as the proliferation of endothelial cells at a concentration of 1000 U/ml. These results indicate that induction of angiogenesis varies with glioma cell lines and angiogenesis does not correspond with proliferation of endothelial cells. TNF-α can inhibit angiogenesis in gliomas in vitro.
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  • Hideyuki KURIHARA, Shigeru MATSUZAKI, Masaru TAMURA, Hiroyuki SUGIMOTO ...
    1995 Volume 35 Issue 4 Pages 215-220
    Published: 1995
    Released on J-STAGE: March 30, 2006
    JOURNAL FREE ACCESS
    The in vivo effects of the single or combined administration of α-difluoromethylornithine (DFMO), an inhibitor of polyamine synthesis, and cis-diamminedichloroplatinum (cisplatin) on the growth of GXII glioma cells inoculated subcutaneously in rats were tested. Treatment with DFMO or cisplatin significantly decreased the bromodeoxyuridine (BrdU) labeling index of tumor tissues. Combined treatment with DFMO and cisplatin achieved a further significant decrease in the BrdU labeling index. All treatments significantly reduced the tissue levels of N1-acetylspermidine and putrescine, and the ornithine decarboxylase (ODC) activity, but little affected the tissue levels of spermidine and spermine, and the activity of spermidine/spermine N1-acetyltransferase. The reduction of ODC activity by cisplatin treatment may be associated with the anti-tumor effect.
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  • Shaikh M. EKRAMULLAH, Youichi SAITOH, Takanori OHNISHI, Norio ARITA, T ...
    1995 Volume 35 Issue 4 Pages 221-226
    Published: 1995
    Released on J-STAGE: March 30, 2006
    JOURNAL FREE ACCESS
    The effects of bromocriptine (CB-154) on the proliferative capacities of prolactinoma and somatotropinoma were investigated by immunocytochemical staining indices of proliferating cell nuclear antigen (PCNA) and Ki-67 (with MIB-1 antibody), and silver staining of nucleolar organizer region (NOR) number in histological sections. Patients with prolactinoma and somatotropinoma were divided into two groups: no preoperative treatment (control group), and treated with CB-154 for 2 weeks before adenomectomy (CB-154 group). The prolactinoma CB-154 group showed a significantly lower PCNA staining index (n = 6, 13.1 ± 2.0%) and Ki-67 staining index (n = 6, 0.2 ± 0.03%) than the control group (n = 4, 27.1 ± 2.1%; n = 8, 1.9 ± 0.5%; respectively) (p < 0.01). The somatotropinoma CB-154 group showed a significantly lower Ki-67 staining index (n = 5, 0.7 ± 0.07%) than the control group (n = 11, 1.2 ± 0.2%) (p < 0.05), but there was no significant difference in PCNA staining index (control: n = 5, 19.1 ± 2.8% vs. CB-154: n = 5, 20.2 ± 1.4%). However, variable intensities of PCNA staining between the cells were observed, resulting in an extraordinarily high staining index. NOR numbers did not vary significantly between the two prolactinoma groups (control: n = 4, 2.0 ± 0.3 vs. CB-154: n = 6, 1.7 ± 0.1) and two somatotropinoma groups (control: n = 5, 1.3 ± 0.1 vs. CB-154: n = 5, 1.4 ± 0.2). Ki-67 staining index with MIB-1 antibody in paraffin sections heated in a microwave oven is more reliable than PCNA staining index or NOR number for evaluating the proliferative capacities of pituitary adenomas. The immunocytochemical procedure with MIB-1 antibody was technically more feasible than that of Ki-67 in frozen section. The results suggest that CB-154 treatment has an anti-proliferative effect on prolactinomas and somatotropinomas.
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  • Shigeru FURUHATA, Toru KAMEYA, Tomoko TSURUTA, Heiji NARITAKA
    1995 Volume 35 Issue 4 Pages 227-230
    Published: 1995
    Released on J-STAGE: March 30, 2006
    JOURNAL FREE ACCESS
    A clinicoendocrinological and ultrastructural comparison of immunohistochemically inactive pituitary adenomas from 14 patients and gonadotropin-positive pituitary adenomas from 26 patients was carried out. Clinicoendocrinological characteristics were similar except the male to female ratios. The immunohistochemically unstable antigenicity of gonadotropin prevents clear immunohistochemical characterization, but the difference between the two types is not absolute and may be an indication of a cell line relationship.
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  • Comparison of Reconstructive Surgery Centered on the Frontal Region and the Parietal Region
    Akihiro TAKAHASHI, Hiroyasu KAMIYAMA, Kiyohiro HOUKIN, Hiroshi ABE
    1995 Volume 35 Issue 4 Pages 231-237
    Published: 1995
    Released on J-STAGE: March 30, 2006
    JOURNAL FREE ACCESS
    Indirect revascularization procedures centered on the parietal region, such as encephalo-myo-arterio-synangiosis (parietal synangiosis) and direct procedures centered on the frontal region using both the anterior and the posterior branches of the superficial temporal artery (STA), such as STA to middle cerebral artery anastomosis combined with encephalo-duro-arterio-myo-synangiosis (frontal anastomosis) were compared in childhood moyamoya disease patients. The parietal synangiosis group consisted of 10 sides in five patients, and the frontal anastomosis group consisted of 30 sides in 15 patients. The development of postoperative collateral circulation was assessed by external carotid angiography, the neurological outcome was monitored for 2 years after surgery, and the intelligence quotient (IQ) was measured at least 6 months after surgery. Frontal anastomosis achieved superior results compared to the parietal synangiosis assessed by development of collateral circulation, in particular to the orbitofrontal artery, the prefrontal artery, and the precentral artery (p < 0.01), and reduction in the incidence of ischemic attacks, such as transient ischemic attacks (p < 0.05). The mean IQ in the frontal anastomosis group was higher than that in the parietal synangiosis group. Vascular reconstruction centered on the frontal region utilizing both the anterior and posterior branches of the STA is more efficacious than only synangiosis centered on the parietal region.
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  • —Case Report—
    Hiroshi HASEGAWA, Shoji BITOH, Kentaro KOSHINO, Jiro OBASHI, Yasushi K ...
    1995 Volume 35 Issue 4 Pages 238-242
    Published: 1995
    Released on J-STAGE: March 30, 2006
    JOURNAL FREE ACCESS
    A 54-year-old female presented with a huge mixed cavernous angioma and astrocytoma in the hypothalamus manifesting as headache, visual field defect, gait disturbance, and convulsion. Radiological studies revealed a huge suprasellar tumor encasing all the major cerebral vessels. Craniotomy disclosed a hemorrhagic tumor poorly demarcated from the surrounding brain which was partially removed. Histological examination of the operative specimen revealed cavernous angioma with low grade glioma in the periphery. The residual tumor responded to radiation therapy remarkably well. An autopsy conducted 3 years later revealed a small hypothalamic astrocytoma with abundant vasculature.
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  • —Case Report—
    Satoshi AYUZAWA, Atsuro TSUKADA, Takao ENOMOTO, Susumu YASUDA, Kazuya ...
    1995 Volume 35 Issue 4 Pages 243-246
    Published: 1995
    Released on J-STAGE: March 30, 2006
    JOURNAL FREE ACCESS
    A 34-year-old male presented with intrasyringal hemorrhage associated with Chiari type I malformation manifesting as a history of repetitive severe pain around his neck and back and progressive sensory disturbance. Magnetic resonance imaging clearly demonstrated syringomyelia at the cervical region associated with Chiari type I malformation and hemorrhage in the syrinx which was strongly suggestive of bleeding into pre-existing syringomyelia or Gowers'' syringal hemorrhage. Irrigation of the syrinx and syringosubarachnoid shunting were performed, but rebleeding occurred causing shunt malfunction. Shunt revision was performed, but a new cavity developed above the original syrinx. Foramen magnum decompression resulted in successful reduction of the new syrinx and subsequent neurological improvement. Simultaneous foramen magnum decompression and syrinx irrigation may be a better approach to treat this disease.
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  • —Case Report—
    Akira WATANABE, Kazuhiro HIRANO, Kenichi MIZUKAWA, Masaki KAMADA, Hiro ...
    1995 Volume 35 Issue 4 Pages 247-250
    Published: 1995
    Released on J-STAGE: March 30, 2006
    JOURNAL FREE ACCESS
    A 74-year-old female presented with intraventricular and subarachnoid hemorrhage due to probable rupture of a basilar artery (BA) aneurysm or a superior cerebellar artery (SCA) aneurysm. She was treated by endovascular therapy using detachable coils through the BA. The BA aneurysm was completely occluded, but part of a coil migrated into the BA from the SCA aneurysm during the procedure. The migrated coil was retrieved using a snare type endovascular retrieving device. The snare loop required concentric closure around the coil by simultaneous pulling of the corewire and a slight forward movement of the tip of the snare catheter. The SCA aneurysm was successfully occluded 1 week later using a shorter coil.
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  • —Case Report—
    Ichiro SUNADA, Yoshinori AKANO, Tsuyoshi INOUE, Katsuhiko TAMURA, Yosh ...
    1995 Volume 35 Issue 4 Pages 251-254
    Published: 1995
    Released on J-STAGE: March 30, 2006
    JOURNAL FREE ACCESS
    An 82-year-old male with intractable bilateral chronic subdural hematomas was treated by emplacement of bilateral subduroperitoneal shunts on the left in 1990 and on the right in 1991. Chronic subdural hematoma recurred in 1992 due to an unusual migration of a shunt catheter into the subdural space. This migration was probably due to inadequate fixation of the shunt. Shunt replacement and fixation with an anchoring wing has resulted in no further complications for 2 years.
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