Neurologia medico-chirurgica
Online ISSN : 1349-8029
Print ISSN : 0470-8105
ISSN-L : 0470-8105
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Volume 31, Issue 9
Displaying 1-10 of 10 articles from this issue
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  • Influence of Extracellular Matrix on the Proliferation and Differentiation of Glioma Cells in Culture
    Masashi TAKAGI, Hajime SUGIHARA, Kazuo TABUCHI
    1991 Volume 31 Issue 9 Pages 553-558
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.553
    JOURNAL FREE ACCESS
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    The influence of extracellular matrix on the proliferation and differentiation of glioma cells in vitro was investigated by culturing glioma cells in collagen gel and on collagen and laminin films. Rat C-6 glioma cells extended thin cytoplasmic processes, proliferated, and differentiated in collagen gel and on collagen film. The cells were stellate with multiple thin processes like the astrocyte in vivo. The intracellular content of cyclic adenosine-monophosphate in rat C-6 glioma cells on collagen film increased approximately four fold over the control level. In laminin film culture, rat C-6 glioma cells extended thin cytoplasmic processes with many knotty structures and proliferated. These findings confirm that extracellular matrix induces the differentiation of glioma cells.
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  • Serological Analysis of Tumor Antigens in Malignant Glioma Patients
    Seiichi YOSHIDA, Ryuichi TANAKA, Kohji ONO
    1991 Volume 31 Issue 9 Pages 559-562
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.559
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    Sera from 27 malignant glioma patients were tested for antibodies to surface antigens of cultured human glioma cells using enzyme-linked immunosorbent assay. Average antibody titer for glioma cell lines was 0.558 ± 0.123, which was significantly higher than in the normal control group (0.165 ± 0.082). Surprisingly, average antibody titer for autologous glioma cells was low (0.207 ± 0.154) in these patients. The results suggest that various surface antigens in glioma cells include specific autologous antigens, antigens associated with gliomas, and common antigens present on cultured normal and malignant cells. These analyses are important in the evaluation of monoclonal antibodies and explanation of escape mechanisms.
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  • Cerebrospinal Fluid Placental Alkaline Phosphatase in the Intracranial Germinomas: Results of Enzyme Antigen Immunoassay
    Nobuo ONO, Hirofumi NAGANUMA, Hiroshi K. INOUE, Masaru TAMURA
    1991 Volume 31 Issue 9 Pages 563-567
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.563
    JOURNAL FREE ACCESS
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    The authors investigated the placental alkaline phosphatase (PALP) activity in cerebrospinal fluid (CSF) by enzyme-antigen immunoassay using polyclonal antibody as a marker for intracranial germinomas in 17 patients with germ cell tumors and 20 with other disorders. The detection limit of PALP activity was 0.072 optical density units equivalent to 5.9 ng/ml. Five of nine germinomas demonstrated high CSF PALP activities before treatment. These high PALP activities became undetectable following radiation therapy. The other tumors were small or had no CSF contact. CSF PALP activity is a useful tumor marker for pure germinomas.
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  • AVDO2 and EEG as Indicators for Treatment of Post-traumatic Brain Swelling
    —Experimental Study—
    Akihiko YABUKI, Hideto MISHINA, Masahiro MIYAZAKI, Minoru MAEDA, Kiyos ...
    1991 Volume 31 Issue 9 Pages 568-574
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.568
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    A cat model of compression ischemia using epidural balloon inflation investigated: 1) the relationship between postischemic cerebral blood flow (CBF) and metabolism and brain swelling, 2) the use of arteriovenous oxygen difference (AVDO2) and electroencephalographic (EEG) frequency band analysis for monitoring CBF and cerebral metabolism, and 3) indications for selecting the therapy. Global ischemia was induced by brain compression, followed by rapid decompression, and AVDO2, CBF, cerebral metabolic rate for oxygen, and EEG were monitored. The animals were divided into delayed brain swelling and no swelling groups. The severity of compression ischemia influenced the recovery of CBF and cerebral metabolism. The AVDO2 and EEG reflected the CBF and cerebral metabolism. These parameters are useful in selecting the therapy for focal brain injury.
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  • Intracranial Pressure Responses During Hyperbaric Oxygen Therapy
    Kiyotaka KOHSHI, Akira YOKOTA, Nobuhide KONDA, Yoshimasa KINOSHITA, Hi ...
    1991 Volume 31 Issue 9 Pages 575-581
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.575
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    The responses of intracranial pressure (ICP) to hyperbaric oxygen (HBO) therapy and arterial gas pressures were investigated. ICP was measured through a ventricular or spinal drainage catheter in patients with brain tumor or cerebrovascular disease. Changes in ICP, heart rate (HR), arterial blood pressure (ABP), and transcutaneous partial pressure of carbon dioxide (PtcCO2) or oxygen (PtcO2) were recorded continuously during air or 100% O2 breathing at I and 2.5 atmospheres absolute (ATA). HR and PtcCO2 decreased and mean ABP was unchanged during HBO inhalation. ICP was reduced at the beginning and tended to increase gradually during HBO inhalation. The change from air to O2 without altering respiratory frequency and volume caused a gradual increase of ICP and PtcCO2 with a transient ICP reduction in an artificially respirated patient. Intentionally reduced respiration to maintain PtcCO2 at the value at 2.5 ATA with air caused the ICP to return to near the value at 2.5 ATA with air even during HBO inhalation. These findings suggest that reduced ICP is initially due to direct cerebral vasoconstriction caused by hyperoxia and is maintained mainly by induced hypocapnia during HBO inhalation. Care is required when giving HBO therapy to patients with a high ICP and/or who are respirated artificially.
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  • Aneurysm of the Lenticulostriate Artery
    —Report of Four Cases—
    Kazunari OKA, Fumiaki MAEHARA, Masamichi TOMONAGA
    1991 Volume 31 Issue 9 Pages 582-585
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.582
    JOURNAL FREE ACCESS
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    Four rare cases of aneurysm of the lenticulostriate artery (LSA) are presented. LSA aneurysms were located at the origin in three patients and distally in one. Two cases were of multiple aneurysms, one was associated with hypertensive intracerebral hematoma (putaminal hemorrhage), and the other with moyamoya disease. Two patients were successfully treated by microsurgical procedures. The occurrence of LSA aneurysm suggests that aneurysm formation and growth are accentuated by hemodynamic alteration and stress.
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  • Brain Metastasis of Testicular Tumor with Massive Hemorrhage
    —Report of Two Cases—
    Takafumi NISHIZAKI, Tetsuji ORITA, Mitsuru TSUHA, Yukio WAKUTA, Masami ...
    1991 Volume 31 Issue 9 Pages 586-589
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.586
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    The authors report two cases of brain metastasis from testicular tumor with massive, sudden intratumoral hemorrhage. In both cases, the hemorrhage occurred during the 1st admission day and carried a high risk of fatality. Early, aggressive surgical removal is advisable before general deterioration. Postoperative chemotherapy with an agent different from the one applied to primary lesion is also recommended because of drug tolerance.
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  • Pediatric Orbital Eosinophilic Granuloma with Intra- and Extracranial Extension
    —Case Report—
    Shigeru FURUTA, Saburo SAKAKI, Takao HATAKEYAMA, Yoshiaki KUMON, Ko NA ...
    1991 Volume 31 Issue 9 Pages 590-592
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.590
    JOURNAL FREE ACCESS
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    A rare case of eosinophilic granuloma of the orbit in a 3-year-old boy presented as right upper eyelid swelling and proptosis. Computed tomographic scanning revealed a soft-tissue dense mass in the lateral wall of the right orbit. Magnetic resonance (MR) imaging demonstrated tumor extension into the orbit, anterior and middle cranial fossae, and extracranial region. The tumor was completely removed. Histological diagnosis was eosinophilic granuloma. No evidence of recurrence was found 14 months later. MR imaging is useful for diagnosis of the lesion, and particularly for surgical management.
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  • Intradural-extramedullary Spinal Cavernous Angioma
    —Case Report—
    Kentaro MORI, Hisato ISHII, Yoshimasa TOMITA, Keiji NAKAJIMA, Keisuke ...
    1991 Volume 31 Issue 9 Pages 593-596
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.593
    JOURNAL FREE ACCESS
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    An extremely rare case of intradural-extramedullary spinal cavernous angioma in a 65-year-old male is reported. The clinical presentation was recurrent episodes of subarachnoid hemorrhage (SAH). Magnetic resonance images disclosed the tumor at the 1st thoracic vertebra, without gadolinium enhancement. The tumor was tightly adhered to the cord surface and successfully removed microsurgically. The previous two reports of this unusual tumor also showed repeated SAH and the tumor attachment to the spinal cord or nerve roots. Intradural-extramedullary cavernous angioma possibly originates in the surface of the spinal cord or nerve root and then extends extraphytically.
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  • Moyamoya Disease Developing from Unilateral Moyamoya Disease
    —Case Report—
    Kikuo KUROSE, Hiroshige KISHI, Yoshihiko NISHIJIMA
    1991 Volume 31 Issue 9 Pages 597-599
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.597
    JOURNAL FREE ACCESS
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    The authors report a case of unilateral moyamoya disease which developed into moyamoya disease 3 years later. Unilateral moyamoya disease is generally defined as moyamoya disease, but the exact relationship is unknown. In this case, occlusive changes developed in the stenotic carotid fork, and in a similar portion contralaterally which was intact. Follow-up 4-vessel angiography is strongly recommended even for unilateral moyamoya disease.
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