Japanese Journal of Medical Science and Biology
Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISSN-L : 0021-5112
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Volume 22, Issue 3
Displaying 1-6 of 6 articles from this issue
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  • THE EFFECT OF ZINC ON THE PRODUCTION OF VARIOUS TOXINS OF CLOSTRIDIUM PERFRINGENS
    RYOSUKE MURATA, SACHIKO SODA, AKIO YAMAMOTO, HIROKO SATO, AKIHARU ITO
    1969 Volume 22 Issue 3 Pages 133-148
    Published: 1969
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.22.133
    JOURNAL FREE ACCESS
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    The synthesis of alpha toxin by a strain of Clostridium perfringens decreased greatly when zinc was omitted from the synthetic medium SM67, while growth was not affected significantly by the depletion of the metal. The metal was also required for the maximum production of kappa toxin, while it was unnecessary for theta toxin. The inhibitory effect of cystine for the production of alpha toxin was partly recovered by zinc. Among divalent cations, manganese is the only one which can partially replace zinc. Cobalt and nickel may have an effect similar to zinc but the results were inconsistent. The supernatant of the culture in the medium deprived of zinc and manganese was toxic to mice while the phospholipase and hemolysin activities were very low. The toxin was neutralized by a specific alpha antitoxin.
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  • SHIGELLOSIS IN CYNOMOLGUS MONKEYS (MACACA IRUS)
    VII. EXPERIMENTAL PRODUCTION OF DYSENTERY WITH A RELATIVELY SMALL DOSE OF SHIGELLA FLEXNERI 2a IN ASCORBIC ACID DEFICIENT MONKEYS
    SHIGEO HONJO, MASAO TAKASAKA, TOORU FUJIWARA, KIYOSHI IMAIZUMI, HIDEMA ...
    1969 Volume 22 Issue 3 Pages 149-162
    Published: 1969
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.22.149
    JOURNAL FREE ACCESS
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    In seven cynomolgus monkeys, ascorbic acid deficiency was experimentally produced by feeding with a compressed diet containing no ascorbic acid for 20 weeks. Then, these monkeys were challenged with 0.02mg (viable count: 7.1×106) of Shigella flexneri 2a strain 5503 by the oral route, resulting in the development of pronounced clinical dysentery in 3 out of 7 deficient monkeys 4, 6 and 12 days after the challenge. On the contrary, none of 4 control healthy monkeys challenged with the same dose of the homologous strain exhibited any signs of clinical dysentery.
    By the near end of the period producing experimental ascorbic acid deficiency, however, the other 2 animals destined for the use in experimental challenge had succumbed to natural infection with S. flexneri 2a. And some of the animals in both the experimental and the control groups harbored S. flexneri 2a or S. flexneri var. Y on the day of challenge. Thus, it should not be neglected that the present experimental challenge with a relatively small dose of S. flexneri 2a may be regarded as having been carried out under the situation that an inapparent natural infection with Shigella was occurring among the monkeys used.
    In any event, these results seem to indicate that the ascorbic acid deficient monkey has, more or less, a lowered resistance to Shigella infection.
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  • EFFECTS OF VARIOUS PASSAGES ON SOME PROPERTIES OF AN ATTENUATED STRAIN OF JAPANESE ENCEPHALITIS VIRUS WITH SPECIAL REGARD TO MOSQUITO INFECTIVITY
    MITSUO TAKAHASHI, SADAO YABE, TOSHIKO OKADA
    1969 Volume 22 Issue 3 Pages 163-174
    Published: 1969
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.22.163
    JOURNAL FREE ACCESS
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    The m strain of an attenuated Japanese encephalitis virus was found not to be infective to the mosquito, Culex tritaeniorhynchus summorosus. Various passages of the virus in hosts including mosquitoes did not essentially modify the non-infective nature of the virus to the mosquito. Neither the intraperitoneal virulence to adult mice nor the optimum pH of hemagglutinin of m strain were markedly altered during the passages, always differing from that of representative epidemic strains, parent Mukai and JaGAr # 01.
    These findings suggested that the m strain possessed characters rendering it eligible as a candidate for live attenuated vaccine for swine, which are known to be the most important amplifier of Japanese encephalitis virus in nature.
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  • THE EFFECT OF CALCIUM ON THE PRODUCTION OF VARIOUS TOXINS OF CLOSTRIDIUM PERFRINGENS
    SACHIKO SODA, HIROKO SATO, RYOSUKE MURATA
    1969 Volume 22 Issue 3 Pages 175-179
    Published: 1969
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.22.175
    JOURNAL FREE ACCESS
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  • THE POSTPARTUM MENSTRUATION OF CYNOMOLGUS MONKEYS KEPT UNDER THE LABORATORY CONDITIONS
    TOORU FUJIWARA, SHIGEO HONJO, KIYOSHI IMAIZUMI, TOMONORI IMAMICHI
    1969 Volume 22 Issue 3 Pages 181-185
    Published: 1969
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.22.181
    JOURNAL FREE ACCESS
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  • EXPERIMENTAL CONCURRENCE OF PEMPHIGUS-LIKE AUTOANTIBODIES AND BULLOUS-LIKE LESIONS A PRELIMINARY REPORT
    R.J. ABLIN
    1969 Volume 22 Issue 3 Pages 187-190
    Published: 1969
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.22.187
    JOURNAL FREE ACCESS
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