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Successor
Volume 34 (1981)
- Issue 6 Pages 329-
- Issue 5 Pages 271-
- Issue 4 Pages 197-
- Issue 3 Pages 113-
- Issue 2 Pages 61-
- Issue 1 Pages 1-
Predecessor
Volume 34, Issue 2
Displaying 1-6 of 6 articles from this issue
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SHUNJI KOZAKI, SHIRO TOGASHI, GENJI SAKAGUCHI1981 Volume 34 Issue 2 Pages 61-68
Published: 1981
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSTwo fragments with molecular weights of 105, 000 (fragment I) and 58, 000 (fragment II) were separated chromatographically from each other after Clostridium botulinum type A derivative toxin adsorbed onto a QAE-Sephadex column was treated with dithiothreitol and urea. They were antigenic and formed crossing precipitin lines against anti-derivative toxin in agar gel diffusion tests. Upon removal of dithiothreitol and urea by dialysis, the two fragments reassembled to reconstruct the derivative toxin molecule.View full abstractDownload PDF (4196K) -
MAKOTO SUZUKI, AKIRA SASAGAWA, TOYOKO INAYOSHI, FUKUYO NAKAMURA, SHIGE ...1981 Volume 34 Issue 2 Pages 69-80
Published: 1981
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSOn 592 cynomolgus monkeys of newly-imported 14 different groups, sero-epidemiological follow-up surveys of natural infections with SV5, measles (MV) and herpes simplex (HSV) were conducted both at the time of arrival and at the end of the 9-week quarantine period at Tsukuba Primate Center for Medical Science (TPC) .
At the time of arrival, the positive rate of antibodies against these viruses greatly varied with different countries of origin. As regards SV5, the positive rate ranged widely from 0 to 94.9% among different import-groups, being markedly low in the Philippine monkey groups. The positive rate of MV antibody was generally very high, varying from 11.1 to 78.2% in almost all import-groups except two groups from Indonesia in which no positive case was detected. Concerning HSV, every import-group had a very high positive rate though the average antibody titer was not so high.
Generally, the positive rates of SV5 and MV markedly increased by the end of quarantine period. Especially, MV positive rate reached 100% in almost all of the import-groups. However, two Indonesian groups showed no increase of SV5 and MV positive rates during the quarantine period. No increase of SV5 positive rate was detected either with any of three Philippine groups. As for HSV, the positive rate remained unchanged or rather decreased during the quarantine period in almost all groups except two Indonesian groups having shown a significant increase.View full abstractDownload PDF (1202K) -
KAZUYA YAMANOUCHI, HIROAKI OHTA, TETSURO KATAOKA, FUMIO KOBUNE, YASUHI ...1981 Volume 34 Issue 2 Pages 81-94
Published: 1981
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSA guinea pig model of mild measles virus infection was established by the intranasal inoculation with Toyoshima strain. The infection was confirmed by the development of both humoral and cell-mediated immunities to measles virus as well as by the demonstration of transient virus growth in the lymphoid tissues. The virus infection caused a transient suppression of delayed hypersensitivity to purified protein derivative (PPD) at both the induction and expression phases, whereas Jones-Mote-type hypersensitivity to ovalbumin developed in a normal fashion. In the virus-infected animals, the suppressed response to the skin reacting factor was observed as well, however in vitro responsiveness of lymphocytes to PPD was not suppressed. On the other hand, transient enhancement of skin reactivity to phytohemagglutinin by virus infection was noticed. These results may indicate subtle alterations of immune functions in guinea pigs during measles virus infection.View full abstractDownload PDF (1295K) -
AKIO YAMADA, MASANORI HAYAMI1981 Volume 34 Issue 2 Pages 95-102
Published: 1981
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSIntravenous inoculation of chicken amniotic fluid (ChAmF) markedly reduced natural killer (NK) cell activity of spleen cells from Japanese quails. The reduction of NK activity was mediated by non-adherent thymus-dependent lymphoid cells which were resistant to treatment with anti-immunoglobulin serum and sensitive to treatment with anti-thymocyte serum in the presence of complement. The suppressing activity was selectively directed to NK cells, since Rous sarcoma virus-specific cytotoxicity or hemagglutinating antibody production against sheep erythrocytes was not suppressed in ChAmF-treated quails. Spleen cells from normal 1-week-old quails had similar characteristics to those from ChAmF-treated 4-week-old quails, lacking NK activity and exhibiting suppressive effect on NK activity, and were also shown to be thymus-dependent. Biological significance of the presence of NK cells and their suppressor cells is discussed in relation to embryonic development and tumor-surveillance mechanism.View full abstractDownload PDF (785K) -
TAKEO FUKUDA, SEIGO YAMAMOTO1981 Volume 34 Issue 2 Pages 103-107
Published: 1981
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESS“Hyuga”fever, reportedly caused by Rickettsia sennetsu, occurring in the west of Japan was suspected to be an endoparasite-borne rickettsiosis. No R. sennetsu, however, was detected in metacercariae found in the muscles of grey mullets (Mugil cephalus) ingested raw by most“Hyuga”fever patients. Instead, another neorickettsia-like organism (SF strain) was isolated occasionally from metacercariae of Stellantchasmus falcatus.
A dog was inoculated with SF strain. It developed mild fever after an incubation period of 10 days. No other clinical sign nor any macroscopic change upon autopsy was noted. The organisms were detected in its blood, lymph nodes and spleen, but not further transmissible. From these findings, the pathogenicity of SF strain to the dog seemed to be much lower than that of Neorickettsia helminthoeca or the Elokomin fluke fever agent of neorickettsia.
These experiments support our presumption that SF strain may be a new member of neorickettsia, although no comparison of the antigenicity between SF strain and other neorickettsiae has been made.View full abstractDownload PDF (407K) -
ALBERT B. SABIN1981 Volume 34 Issue 2 Pages 109-112
Published: 1981
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSDownload PDF (487K)
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