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Volume 40, Issue 3
Displaying 1-4 of 4 articles from this issue
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Nobuo OHTA, Yukio HOSAKA1987 Volume 40 Issue 3 Pages 95-107
Published: 1987
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSTo characterize the mechanisms of induction and regulation of the cell population involved in granuloma formation around eggs of Schistosoma japonicum, we utilized a simple method of in vitro experiments. Lyt1+2- T cells were essential for in vitro responses to the intact S. japonicum eggs, which were assumed to be comparable to in vivo granulomatous responses. T-cell responses seemed to be macrophage-dependent, and responding T cells produced IL-2-like activities in the culture supernatant. Sera taken from chronically infected mice acted as regulatory factors to these T-cell responses as was the case in in vivo granuloma formation. The method used here was simple and highly informative for the studies on pathogenesis of schistosomiasis japonica.View full abstractDownload PDF (2150K) -
Eiko SUZUKI, Akira NOGUCHI, Hisao TAKEDA1987 Volume 40 Issue 3 Pages 109-117
Published: 1987
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSEnzyme-linked immunosorbent assay (ELISA) for diagnosis of Sendai virus infection in mice was evaluated. A large-scale survey of infected mice showed that ELISA is approximately 100 times more sensitive than the hemagglutination-inhibition or complement-fixation test. Although a few SPF mice showed false-positive reactions at a serum dilution of 1: 40, further dilution to 1: 80 eliminated the non-specific reaction. It was shown that ELISA is a highly satisfactory method for examination of Sendai virus infection in mice.View full abstractDownload PDF (638K) -
Jean TAYLOR-WIEDEMAN, Yasuo MORITSUGU, Kikuko MIYAMURA, Shudo YAMAZAKI1987 Volume 40 Issue 3 Pages 119-130
Published: 1987
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSA seroepidemiologic study to detect class-specific antibody against hepatitis A virus (HAY) was made with 831 randomly collected sera (415 in 1973 and 416 in 1984) from healthy Japanese. Competitive-inhibition, IgG, IgA, and IgM anti-HAV enzyme-linked immunosorbent assays (ELISA) were used. Both collections showed a low prevalence of IgG anti-HAY in young age groups and it increased rapidly at middle age and plateued at ≥ 94% prevalence in the older age groups. However, two age groups spanning ages 25-34 demonstrated statistically lower IgG anti-HAY age prevalences in 1984 vs 1973 (P<0.001), with an average 10-year prevalence shift. These data suggest that there has been no significant level of HAY infection to alter antibody prevalences in Japan from 1973 to 1984. The markedly decreased incidence of HAY infection in Japan has created a presently large and growing population of HAY susceptibles.View full abstractDownload PDF (953K) -
Koji FUJIMOTO, Keiji TERAO, Fumiaki CHO, Shigeo HONJO1987 Volume 40 Issue 3 Pages 131-135
Published: 1987
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSAntigenicity of IgG was compared among human, the cynomolgus monkey, the African green monkey and the squirrel monkey by the quantitative precipitation test using purified IgG of and rabbit anti-IgG serum to each species. Clear cross-antigenicity was observed between the cynomolgus monkey and the African green monkey and less clear cross-antigenicity between human and the cynomolgus monkey or the African green monkey. The cross-antigenicity observed between the squirrel monkey and the other three species examined was evidently weak.View full abstractDownload PDF (353K)
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