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Volume 31 (1978)
- Issue 5-6 Pages 371-
- Issue 4 Pages 317-
- Issue 3 Pages 225-
- Issue 2 Pages 91-
- Issue 1 Pages 1-
Predecessor
Volume 31, Issue 2
Displaying 1-6 of 6 articles from this issue
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MASAMI KUROKAWA, SETSUJI ISHIDA, SADAO ASAKAWA, SABURO IWASA1978 Volume 31 Issue 2 Pages 91-103
Published: 1978
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSThe effect of bacterial endotoxin on the change in peripheral leukocyte population in mice due to the lymphocytosis-promoting factor (LPF) was investigated. Endotoxin affected not only the total leukocyte count but also the leukocyte proportions at any observation time. Both the coefficient and the intercept of regression of the leukocytic response on dose of LPF were modified by endotoxin. Therefore, in a valid biological assay for LPF using the peripheral leukocyte count as a response, a common reference preparation available for any test materials, irrespective of presence or absence of endotoxin, will be impracticable. Two reference preparations were tentatively established, one being a vaccine and the other an LPF preparation containing little endotoxin. A unitage of LP activity was assigned to each reference preparation.
The results also showed that an LPF material to be tested for its possible effects on the lymphatic tissues or the reticuloendothelial system should be free from endotoxin.View full abstractDownload PDF (1070K) -
KAYOKO ARAI, JUNICHI YASUDA1978 Volume 31 Issue 2 Pages 105-118
Published: 1978
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSThe agglutination test with latex particles coated with aggregated human IgG was introduced into the evaluation of Coombs serum as an additional test for anti-IgG antibody activity. In Coombs sera prepared by the conventional immunization method employing Freund's adjuvant, latex agglutination titers were found much lower than those of anti-D-coated red cell agglutination. On the other hand, in sera prepared by other immunization methods, such as the one according to Haynes and Chaplin (1971), anti-IgG antibody response was readily observed by IgG-coated latex agglutination. Specificity of anti-IgG antibodies in the latter sera seems to be predominantly directed to aggregated human IgG.View full abstractDownload PDF (3917K) -
YASUHIRO YOSHIKAWA, MASAHIRO ITO, KAZUYA YAMANOUCHI1978 Volume 31 Issue 2 Pages 119-134
Published: 1978
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSInduction of agammaglobulinemia in Japanese quails was attempted by various procedures of bursectomy (BX) including hormonal BX (H-BX) with testosterone, surgical BX (S-BX), chemical BX (C-BX) with cyclophosphamide and irradiation with γ-ray. Immunosuppressive effect of BX was evaluated by antibody production in response to immunization with bovine serum albumin and sheep red blood cells, by the level of natural antibody, and by the amount of immunoglobulins in sera. As a result, two procedures, i.e. combination of H-BX, S-BX, and C-BX and combination of H-BX, S-BX and irradiation were found to induce most frequently complete aggamaglobulinemia in which neither immunoglobulin nor antibody production was detected. Mechanisms of immunosuppression of these BX procedures were discussed from the morphological aspect of development of the bursa.View full abstractDownload PDF (8261K) -
TOSHIO SHIMADA, RIICHI SAKAZAKI1978 Volume 31 Issue 2 Pages 135-142
Published: 1978
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSThe serology of 87 strains ofPlesiomonas shigelloideswas studied. Thirty O antigenic groups and 11 H antigens were defined within the 87 strains, and an antigenic schema consisting of 40 serovars was established. Some O antigens ofP. shigelloideswere identical or closely related to those of someShigellaserovars.View full abstractDownload PDF (539K) -
TOHRU TOKUNAGA, SABURO YAMAMOTO, REIKO M. NAKAMURA, AKIRA KUROSAWA, TO ...1978 Volume 31 Issue 2 Pages 143-154
Published: 1978
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSThe prophylactic and therapeutic effects of BCG on the tumors induced by 3-methylcholanthrene (MCA) were studied comparatively between two inbred mouse strains, SWM/Ms and C3H/He, the first tumor appeared 5 weeks after MCA and the cumulative tumor incidence reached almost 100% within 20 weeks. On the other hand, the first tumor appeared 8 weeks after MCA in SWM/Ms, the number of tumor-bearers increased more slowly than in C3H/He, and the final tumor incidence (at 30 weeks) was about 90-80%. Single subcutaneous injection with BCG 2 weeks prior to MCA significantly protected SWM/Ms from tumor development, but not in C3H/He. These tumors, once appeared grew progressively and killed the hosts equally in both the strains. Intratumor (i.t.) injection with BCG showed more or less therapeutic effects in SWM/Ms; most tumors regressed or retarded after BCG. The time period after tumor-appearance to tumor-death was prolonged in most of SWM/Ms mice given it. injection with BCG, except a few mice that died earlier than non-treated controls after BCG. Contrary, no therapeutic effect of it. injection with BCG was observed in C3H/He. Different host responses to BCG between SWM/Ms and C3H/He were found by the peritoneal macrophage disappearance test and the footpad reaction test; SWM/Ms was a highresponder to BCG and C3H/He was a low-responder. The marked differences between SWM/Ms and C3H/He in prophylactic and therapeutic effects of BCG on the autochthonous tumors were discussed in terms of difference of the host immune response to BCG that is defined genetically.View full abstractDownload PDF (1196K) -
1978 Volume 31 Issue 2 Pages 155-223
Published: 1978
Released on J-STAGE: March 19, 2010
JOURNAL FREE ACCESSDownload PDF (7972K)
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