Japanese Journal of Medical Science and Biology
Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISSN-L : 0021-5112
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Volume 41, Issue 5-6
Displaying 1-3 of 3 articles from this issue
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  • ANTIGENIC DETERMINANTS RESULTING FROM POLYMERIZATION OF IMMUNOGLOBULIN G
    Kayoko ARAI, Junichi YASUDA, Takako SASAKI, Kunio YONEMASU
    1988 Volume 41 Issue 5-6 Pages 189-196
    Published: 1988
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.41.189
    JOURNAL FREE ACCESS
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    Antibodies against heat-aggregated human IgG (AHG) were raised in rabbits and those against immune complex (IC) of tetanus toxoid and its human antitoxin (T/aT) in rabbits and mice. These antisera were analyzed by the Ouchterlony double diffusion technique against native monomeric human IgG (NHG), AHG and chemically linked human IgG (poly-G) . The appearance of neoantigens was demonstrated with human IgG bound to its corresponding antigen or denaturated nonspecifically. The results are indicative of the existence of a common determinant shared with AHG and T/aT, in addition to those of their own.
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  • IN VITRO AUGMENTATION OF NATURAL KILLER ACTIVITY OF PERIPHERAL BLOOD CELLS FROM CANCER PATIENTS BY A DNA FRACTION FROM MYCOBACTERIUM BOVIS BCG
    Harukazu MASHIBA, Keiko MATSUNAGA, Hirotsugu TOMODA, Motonosuke FURUSA ...
    1988 Volume 41 Issue 5-6 Pages 197-202
    Published: 1988
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.41.197
    JOURNAL FREE ACCESS
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    Effects of a DNA-rich fraction from Mycobacterium bovis BOG (MY-1) on the natural killer (NK) activity of peripheral blood lymphocytes (PBL) from healthy donors and cancer patients were studied in vitro. The NK activity of PBL was assessed after incubating PBL for 24 hr in the presence or absence of MY-1 or that digested preliminarily with RNase or DNase. One microgram per ml of MY-1 or that digested with RNase augmented the NK activity of PBL from healthy donors. The activity of MY-1 was abolished by the digestion with DNase. Similarly, the NK activity in all of six patients with gastric cancer, 12 patients with colonic cancer, and six patients with uterine cancer was augmented by incubation with MY-1 (1μg/ml and 10μg/ml), although the degree of augmentation varied depending upon the origin of PBL.
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  • SYMPOSIUM ON TOXINS
    1988 Volume 41 Issue 5-6 Pages 203-247
    Published: 1988
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.41.203
    JOURNAL FREE ACCESS
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