The influence of atropine, gastrin, prostaglandin F
2α on resting anorectal pressure and recto-anal reflex was studied by manometry using inflused open tiped catheter method.
The results were as follows ;
1) Rectal pressure was increased by intravenous administration of gastrin and prostaglandin F
2α and not effected by atropine.
2) Anal canal pressure was increased by prostaglandin F
2α, decreased by atropine and not effected by gastrin. Anal canal contraction wave was not effected by any agents, but slightly clear by gastrin.
3) Drop of anal canal pressure induced by rectal distension was increased by prostaglandin F
2α, decreased by atropine and not effected by gastrin.
These findings suggest that prostaglandin F
2α may increase low anal canal pressure in postoperative children with anal atresia and may make postoperative obscure recto-anal reflex clearer and that atropine may decrease high anal canal pressure of chronic constipation.
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