Background : Treatment for locally advanced rectal cancer with posterior invasion remains a difficult clinical problem. The aim of this study was to elucidate the prognostic significance of sacral resection for these lesions.
Methods : Between 1991 and 2002, 36 patients who underwent sacral resection, including total pelvic ex-enteration with sacral resection (TPES) in 25 patients and abdominoperineal resection with sacral resection (APRS) in 11 patients, for locally advanced primary or recurrent rectal cancer with posterior invasion were studied retrospectively for survival according to the degree of posterior invasion. The posterior invasion was histologically classified as invasion to the sacral cortex and the presacral connective tissues (PCT), which contain the fibrous layer of periosteum and parietal endopelvic fascia.
Results : A significant difference in survival after sacral resection was seen according to the grade of histological posterior invasion (p=0.0492) . The 5-year survival rates were 0% in 8 patients with invasion to the sacral cortex, 14.8 % in 9 patients with invasion to PCT, and 49.8 % in 19 patients without the invasion.
Conclusion : Sacral resection may benefit patients with posterior invasion of advanced rectal cancer, although alternatives should be explored in patients with histological invasion to the sacral cortex.
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