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Volume 31 (1978)
- Issue 6 Pages 553-
- Issue 5 Pages 429-
- Issue 4 Pages 325-
- Issue 3 Pages 201-
- Issue 2 Pages 87-
- Issue 1 Pages 1-
Predecessor
Volume 31, Issue 6
Displaying 1-8 of 8 articles from this issue
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Y. Yoshida, [in Japanese]1978 Volume 31 Issue 6 Pages 553-557,633
Published: 1978
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSPhysicians are reminded the following three facts on treating the patients with ulcerative colitis ; 1) The disorder is a chronic inflammation and the affected colon is much irritated. 2) Immunological process is playing a role in the pathogenesis. 3) Approximately 20% of the patients will be ultimately treated surgically.
General measures of treatment are the colonic, physical and emotional rest, maintenance of nutrition and of fluid and electrolytes balance, and other managements for improvement of general status.
As chemotherapeutic measures, in patients with mild or moderate colitis Salazopyrine is the drag of first choice and steroid enema is the second. Oral administration of steroid is given to patient with refractory and severe colitis. In acute fulminant colitis no oral intake is allowed, and all medications and nutritions are given parenterally. If no definite improvement is seen within a week surgical treatment is urgent. Indication of surgical treatment for ulcerative colitis is not definite, but the cases which do not respond to medical treatment for some weeks are generally indicated. Since the prognosis for patients with severe colitis on medical management is not good, earlier surgery has been recommended.
For maintenance of remission, administration of Salazopyrine may be used for more than 6 months.View full abstractDownload PDF (426K) -
M. Inoue, I. Yoshida, S. Nagata1978 Volume 31 Issue 6 Pages 558-560,633
Published: 1978
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSThe incidence of ulcerative proctitis or proctosigmoiditis is 10 to 40% of whole ulcerative colitis patients in USA, British Kingdom and also in Japan. In our series, extent of involvement was limited to rectum or rectosigmoid in 10 out of 43 cases of ulcerative colitis. By the administration of salazopyrin, complete symptomatic relief was obtained in 75%, and endoscopic remission was observed in 69% of the cases. Patients in which the effects of solazopyrine were not complete, responed well to local steroid therapy. Medical management and prognosis of ulcerative proctitis were discussed.View full abstractDownload PDF (274K) -
K. Kobayashi, A. Kitano, M. Murai, Y. Tanaka, T. Katayama, S. Kuwajima ...1978 Volume 31 Issue 6 Pages 561-566,634
Published: 1978
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSDetail observations of clinical course and prognosis were carried out in 54 cases with wide involved ulcerative colitis which could followed by medical management. Our medical therapy against patients with active but uncomplicated ulcerative colitis is based upon immunological and hematological findings. Several authors reported generally a poor lym-phocyte response in ulcerative colitis, but we found invariable high PHA responses in several cases of initial active stage in untreated ulcerative colitis, and then in remission there were always low values. Influence of salicylazosulphapyridine (SASP) on peripheral blood lym-phocytes in healthy subjects was examined by chromium release assay. Inhibition by SASP on the PHA-induced cytotoxic action of human lymphocytes was observed by using mouse L cells as target cell. This results suggest that SASP has some inhibitory action for immune system. It was emphasized that SASP is the drug of first choice in patients not only with mild and moderate colitis but also with severe colitis.
The clinical course should be followed by checking the appearance and laboratory findings such as WBC counts, body temperature and ESR. In addition, the findings of the blood coagulation and fibrinolysis are necessary to detection of prognosis.
The only SASP administration recovered complete remission in 57 % of entire colitis and in 85% of left side colitis. Patients who felt epigastral discomfort or had leucopenia could be exchanged one part of oral administration of SASP to suppositorie.View full abstractDownload PDF (220K) -
Selective Administration of Steroid Hormone Into the Superior and/or Inferior mesenteric ArteryM. Motegi, S. Baba1978 Volume 31 Issue 6 Pages 567-571,634
Published: 1978
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSSelective administration of steroid hormone into the mesenteric artery was attempted to treat severe cases of ulcerative colitis.
Twenty one patients of severe ulcerative colitis were treated by administering water-soluble prednisolone directly into mesenteric arteries after the completion of selective angiography. Seventeen of them were remarkably improved, and some of them were followed by complete remission.
Mortality rate of emergency operation for severe ulcerative colitis is still very high, and colonofiberscopy and barium enema were contraindicated.
Selective angiography is a useful method to know the range of the involvement of the lesion. It can be utilized for the treatment of severe cases in order to prevent emergency operations. Two cases of toxic megacolon was successfully treated by this method.View full abstractDownload PDF (285K) -
H. Ishimuro, [in Japanese], [in Japanese], [in Japanese], [in Japanese ...1978 Volume 31 Issue 6 Pages 572-577,635
Published: 1978
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSAs the long-term survials of the patients with acute leukemia have gained recently by means of intensive cytotoxic therapy, anorectal complications have frequently been encountered in these patients.
There were sixteen anorectal complications among 147 patients treated at the 1st Department of internal medicine, Nagoya university Hospital over a six-year period.
The twelve cases of 16 anorectal complications were treated with conservative therapy and the four cases were with incision and drainage technique.
Although it is said that incision and drainage must be performed within a complete hematological remission, the adequate incision and drainage may be necessary in any stage except acute stage.
If both subjective and objective symptomes deteliorate progressively even when abscess is inmature, because incision and drainage may prevent from sepsis and relieve pain.
Incision wound must be limited in the minimal size where exough drainage is enabled for the hemorrhagic diathesis acute leukemia.
The features of anorectal complication in acute leukemia.
(1) Healing of the incisino wound is delayed and sometimes imperfect.
(2) Abscess fluid is pus or watery liquid.View full abstractDownload PDF (276K) -
S. Kodaira, Y. Koyama, T. Hirota, K. Ohmori, E. Ikeda1978 Volume 31 Issue 6 Pages 578-585,636
Published: 1978
Released on J-STAGE: December 03, 2009
JOURNAL FREE ACCESSIt is well known from studies in rats that Dimethylhydrazine (DMH) administered subcutaneously is an effective carcinogen for large intestine.
In this paper how fecal stream influence the pathogenesis of DMH induced colorectal tumor in rats (Donryu strain, male) was studied.
The results of our experiments were as follows:
1st. experiment: In the large bowel isolated completely from fecal stream, tumors were induced by administration subcutaneously of DMH, but frequency of induced tumors in these bowel was lower than in nonisolated large bowel. From these observation it is assumed that DMH or it's metabolites would reach the mucosa of large bowel not only via the biliary route and fecal stream, but also via blood stream.
2nd. experiment: Tumors were also induced in the colon segment that transposed between choledochus and small intestine by subcutaneously administration of DMH.
3rd. experiment: Right or left sided large bowel was isolated from fecal stream after DMH treatment. It was demonstrated that DMH-induced tumor was larger in size but smaller in number in the segment of the large bowel isolated from fecal stream than in the large bowel with fecal stream. It was suggested that normal fecal stream have some important effects upon incidence of induced tumors and growth of tumors.View full abstractDownload PDF (723K) -
H. Fukasawa, T. Kasukawa, S. Kamata, T. Osaku, H. Ando, S. Ichimori, M ...1978 Volume 31 Issue 6 Pages 586-592,636
Published: 1978
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSRecently 2 cases of anal carcinoma associated with fistula were experienced in our department of surgery, and one of them suggested the carcinoma originated from anal fistula.
There are 29 cases of carcinoma in anal region associated with fistula clearly detailed in literatures of Japan during the 18 years from 1960 to April 1978.
These cases also were reviewed and analysed in this paper.View full abstractDownload PDF (361K) -
1978 Volume 31 Issue 6 Pages 593-631
Published: 1978
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSDownload PDF (3323K)
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