To evaluate the relationship between Clostridium difficile (CD) infection (CDI) and postoperative complications after colorectal surgery, 185 patients who underwent surgery for colorectal cancer in our hospital between 2014 and 2016 were reviewed. The mean age was 70.7 years. As possible risk factors for postoperative CDI, advanced age (≥ 65) and a history of antibiotics treatment, chemotherapy, abdominal surgery, and hospitalization prior to surgery was recognized in 131, 3, 10, 18, and 52 patients, respectively. Forty-seven patients (25.4%) had multiple risk factors for CDI. CD toxin and CD antigen were positive in 17 and 29 patients, respectively, and CD carriers were more frequently found in patients with multiple risk factors for CDI (p = 0.031). Severe diarrhea and CD-associated diarrhea (CDAD) were recognized in 26 and 8 patients, respectively. Anastomotic leakage occurred in 7 patients (3.8%), and its incidence was 15.4% in patients with severe diarrhea and 25.0% in patients with CDAD (p = 0.001). Postoperative CDAD and severe diarrhea were identified as risk factors for anastomotic leakage. Because CD carriers had multiple risk factors for CDI, preoperative assessment and preparation focusing on such patients with multiple risk factors may help to reduce postoperative complications, including anastomotic leakage.
View full abstract