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Volume 47, Issue 7
Displaying 1-12 of 12 articles from this issue
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1994 Volume 47 Issue 7 Pages 547-551
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSDownload PDF (6657K) -
Y. Akagi1994 Volume 47 Issue 7 Pages 552-563
Published: 1994
Released on J-STAGE: December 03, 2009
JOURNAL FREE ACCESSThe purpose of this study was to investigate the role of Matirix metalloproteinase-2 end 9 ( MMP-2 and 9 ) in liver metastasis of colon carcinoma. We developed the liver metastasis model by transplanting the cell line of human colon carcinoma to caecum carci soma of nude mice. The capacity of the carcinoma tissue to secrete MMP-2 and 9 was determined by a zymogram. The relation between the secretion of MMP-2 and 9 and liver metastasis was evaluated.
The results of the experiments were as follows
1) Liver metastasis of the transplanted colon carcinoma was found in 57 % of experimental mice.
2) MMP-2 was secreted from cultured cells of human colon carcinoma, but MMP-9 was not secreted.
3) The secretion of MMP-2 from experimental caecal carcinoma was found in 60% and that of MMP-9 was found in 25% .
4) The secretion of MMP-2 from metastatic liver tumor was found in 78 %, and that of MMP-9 was found in 89% .
5) The secretion of MMP-9 was found in 42 % of mice having caecal carcinoma with liver metastasis but not found in those having caecal carcinoma without liver metastasis. And the secretion of MMP-9 was significantly more marked in the liver metastatic tumor than the caecum carcinoma.
Our findigns showed that secretion of MMP-2 and 9 by the experimental model colon carcinoma differed according to organ-specific microenvironments. And we considered that MMP-2 and 9 are very important factors of liver metastasis.View full abstractDownload PDF (8306K) -
Mainly Examining the Correlation Between the Degree of Invasion and Other Adverse Prognostic FactorsS. Okabe1994 Volume 47 Issue 7 Pages 564-575
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSWe have investigated usefulness of our new classification of the degree of invasion as a landmark of outcome of patients with submucosal invasive colorectal carcinoma.
We used the term "sm depth" to refer to vertical extension of carcinoma in the interstitium, defining "sm width" as horizontal extension of it. As a result of histopathological investigation of 14 cases of submucosal invasive carcinoma with metastasis and 158 cases without metastasis, our new classification showed good correlation with presence or absence of vascular invasion and metastasis, if it can be defined as minimal invasion (grade-1) when sm depth less than 500 micron and sm width less than 2mm, whereas as massive invasion (grade-III) when sm depth more than 1000 micron or sm width more than 4mm.
In conclusion, our new, ;classification of the grade of invasion is significantly useful for decision about necessity of subsequent intestinal resection after endoscopic resection of colorectal submucosal invasive carcinoma.View full abstractDownload PDF (6956K) -
S. Kimura, I. Kudoh, H. Suzuki, M. Fukushi, Y. Sakata, T. Aizawa1994 Volume 47 Issue 7 Pages 576-581
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSA 17-year-old male with diarrhea and low abdominal pain, who had a history of several operations for perianal abscess, was admitted on August 9, 1993. On the examinations of the GI tract, he was diagnosed as having Crohn's disease. He had a right hydronephrosis caused by severe inflammation of ileo-cecal lesion. On CT scan examination, the right ureter was involved in the inflammatory mass which was related to thickening of the ileo-cecal wall. After total elemental enteral hyperalimentation (2400 kcal/day) for about 2 months, the thickening of the ileo-cecal wall was improved and right hydronephrosis and hydroureter had disappeared. He had complete remission on IOIBD score. This case indicates that total elemental enteral hyperalimentation is beneficial not only for the alimentary canal complications, such as fistel formation, but also for the extra-alimentary canal complications, such as hydronephrosis, because of its healing effect on local inflammation.View full abstractDownload PDF (3452K) -
H. Fujii, H. Iino, Y. Miyasaka, Y. Honda, J. Okuda, Y. Iimuro, Y. Mats ...1994 Volume 47 Issue 7 Pages 582-588
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSA 57-year-old man with solitary adrenal metastasis from carcinoma of the ascending colon is reported herein. Recurrent disease was suspected because of an elevated level of serum carcinoembryonic antigen, and solitary adrenal metastasis was comfirmed by computed tomography scanning three years after right hemicolectomy. Right adrenalectomy was carried out. Surgical specimen was 6 x 4 x 3cm in size and 66 g in weight. The cross section showed a mostly yellowish-white and hemorrhagic tissue with a portion of normal adrenal tissue. Histopathology revealed that the metastatic adrenal tumor had moved from carcinoma of the colon. The postoperative course was uneventful and the patient has disease-free survival of 9 years after adrenalectomy and 12-year survival after the initial surgery. Although the prognosis of adrenal metastasis from colorectal cancer is usually poor, we believe that patients with solitary adrenal metastasis will benefit from complete removal of the metastasis.View full abstractDownload PDF (5198K) -
T. Tanaka, M. Takano, T. Fujiyoshi, K. Takagi, N. Fujimoto, R. Kikuchi ...1994 Volume 47 Issue 7 Pages 589-595
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSA 16-year-old male visited the hospital because of lower abdominal pain. He strongly hit his body on the ground when he fell from a bicycle four weeks ago. Barium enema study revealed stenosis of the rectum due to extrinsic compression. Colonoscopy revealed the finding like a submucosal tumor of the rectum. Abdominal ultrasonography, CT and MRI revealed a homogeneous cystic tumor. Presacral hematoma due to adbominal trauma was strongly suspected. But it is difficult to make a correct diagnosis in the case of a long interval after the trauma. Under the diagnosis of the presacral hematoma or extrarectal tumor, operation was performed. The pathological examination of the resected specimen revealed intramural hematoma of the rectum. We reported a very rare case of the intramural hematoma of the rectum together with a review of Japanese literature.View full abstractDownload PDF (3149K) -
M. Kume, K. Yonezawa, H. Azuma, S. Mori, T. Toneyama, M. Futamura, H. ...1994 Volume 47 Issue 7 Pages 596-602
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSA case of rectal cancer associated with penile metastasis is reported. The patient underwent an abdominoperineal resection of the rectum (Miles'operation). total prostatectomy and ureterocystostomy at the age of 51. At the age of 57, he was hospitalized again because of local recurrence revealed by CT, MRI and internal iliac artery angiography. He was treated with intraarterial injection of epirubicin 30mg and mitomycin C 10mg in additiom to radiation therapy (total radiation dose was 60 Gy). Four months later, radiation therapy was performed on the right inguinal lesion due to lymph node metastasis (total radiation dose was 60 Gy). Eight months later, hard nodules on the glans and the shaft of the penis were found, which were confirmed to be penile metastasis of rectal cancer by biopsy. This is the eleventh case of penile metastasis of rectal cancer in Japan. Either retrograde venous transplant or retrograde lymphatic permeation was suspected as the mechanism of metastasis.View full abstractDownload PDF (3066K) -
H. Ishida, T. Higuchi, I. Hojo, H. Nakajima, T. Gonda, H. Hirukawa, Y. ...1994 Volume 47 Issue 7 Pages 603-608
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSA very rare case of diffusely infiltrating carcinoma of the ascending colon associated with ileocolic intussusception is presented together with a review of the literature thereon. The mechanism of intussusception in this case and its differental diagnosis are also discussed.
A 58-year-old man was hospitalized because of abdominal pain. Computed tomo-graphy and ultrasonography revealed multiple concentric rings in the right lower abdo-men. Lower intestinal series showed complete obstruction of the ascending colon. Pal-liative right colectomy was performed because of para-aortic lymphnode involvement. Macroscopic features of the resected specimen indicated thickened intestinal wall and cobblestone appearance that were consistent with those of diffusely infiltrating carcinoma. Histological examination revealed poorly differentiated adenocarcinoma. He died of DIC 11 months after operation. It is of great interest that this case presented atypical clinical features as a diffusely infiltrating carcinoma of the large-bowel.View full abstractDownload PDF (3000K) -
T. Kiyama, K. Egami, Y. Taniguchi, M. Wada, M. Yoshioka, T. Shimomura, ...1994 Volume 47 Issue 7 Pages 609-614
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSPrimary malignant lymphoma of the rectum is a rare disease and difficult to diagnose. We report a case diagnosed by aspiration biopsy cytology before surgery. A 32 year-old man had been complaining about a disturbance of defecation and viscous bloody stool since December 1992. A rectal tumor was found at another hoispital. Histopathological examination of the biopsy specimen showed non-specific granulation (Group 2). Colostomy was performed in March 1993. He was admitted to our hospital in July 1993. Lymph nodes were not palpable. Digital examination revealed circumferential stenosis of the anus and rectum, and soft tissue was palpated by index finger insertion. Aspiration biopsy was performed via the anus, and cytology examination showed mainly atypical medium-sized lymphocytes. We diagnosed it as class III b (malignant lymphoma). Miles' operation was performed on July 14, 1993. Pathological diagnosis was non-Hodgkin's lymphoma : diffuse medium-sized cell type, B cell type, a2 n(-) P0 H0 M(-), stage II. VEPA was used to perform adjuvant chemotherapy. He visited the outpatient-clinic of our hospital with no signs of recurrence on April 1, 1994.View full abstractDownload PDF (4361K) -
T. Ichihara, M. Sinkai, T. Urakawa1994 Volume 47 Issue 7 Pages 615-621
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSClinicopathological chracteristics of 10 patients with colorectal cancer complicated by obstructive colitis (OC group) were compared with of 40 patients with colorectal cancer complicated not by OC but by bowel obstruction (control group). In the OC group, the mean age (73.8 years) was higher than that of the control group, cardiovascular disease that required treatment was in 9 of 10 patients, and the mean duration of illness was longer than in the control group (p<0.05). OC occurred frequently in patients with ileus cancer of the rectum (4/10, 40%) and in those with ileus cancer of the sigmoid colon (4/13, 30.8%). In the OC group, cancer was non-circumferential in 40% of the patients, but the tumor diameter or the oral / anal girth ratio of the tumor was not different from the control group. The occurrene of OC was not necessarily dependent on the stage of the cant er or the severity of obstruction and was also unrelated to the degree of intestinal dilation. Normal mucosa was present at a width of 3-55cm between the oral margin of the cancer and the lesion of OC in all patients. Exploration for OC in the intestine on the oral side of the cancer is considered to be important for treatment of colorectal cancer with bowel obstruction.View full abstractDownload PDF (445K) -
K. Togashi, F. Konishi, M. Okada, T. Satoh, K. Furuta, M. Kojima, K. K ...1994 Volume 47 Issue 7 Pages 622-627
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSPolyethylene glycol-electrolyte lavage solution (PEG-ELS) was administered to 97 patients at home to prepare their bowels for total colonoscopy. The results of colonoscopic observation revealed that the preparation was only slightly worse when the PEG-ELS preparation was performed at home than when it was performed at hospitals. No severe side effects were observed in patients who performed the PEG-ELS preparation at home. Patients' compliance with the home method was better than that of the hospital method. Our study revealed that PEG-ELS preparation at home was as useful and safe as PEG-ELS preparation at hospitals. PEG-ELS preparation at home has many advantages, e. g. patients are hospitalized for a shorter period than PEG-ELS preparation at hospitals, and the capacity of the toilet in hospitals is not a problem. From these results this method is considered to be widely usable as a bowel preparation for total colonoscopoy.View full abstractDownload PDF (409K) -
1994 Volume 47 Issue 7 Pages 628-643
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSDownload PDF (1191K)
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