We investigated the significance of surgical treatment for pulmonary metastases from colorectal cancer in patients with previous liver metastasectomies.
Both liver and pulmonary metastases were resected in 12 patients from January 1977 through December 2000 in our institute. Seven patients had liver metastases synchronously with primary tumor, three of whom also had lung metastases synchronously. Of the other five patients who had metachronous liver metastases, pulmonary metastases were detected simultaneously with liver metastases in 2 patients and they were de-tected later in 3 patients. No perioperative morbidity occurred and all patients were discharged.
Five-year survival rate and the disease-free survival rate of 12 patients after the last metastasectomy were 40.0% and 12.5%, respectively. One patient is still alive without recurrence more than 10 years after the last metastasectomy.
The average interval between detection of each metastasis of 9 patients in whom metastases recurred within one year after the last metastasectomy was significantly shorter than that of 3 patients without early recurrence (7.1 vs. 37.0 months, p<0.01).
Patients with both liver and pulmonary metastases from colorectal cancer should be considered for surgical treatment, especially when the interval between detection of each metastasis is long.
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