The purpose of this study was to investigate the risk fatcors of local recurrence and distant metastasis. Forty-four patients undergoing surgery for rectal cancer invading proper muscle were evaluated clinicopathologically. Four findings were recognized as risk factors of local recurrence, lymph node metastasis, moderately or poorly differenciated adenocarcinoma in the most invasive area of the tumor, lymhpatic vessel involvement (ly2 or ly3), and NPG type (by Shimoda's classification). Three risk factors of distant metas-tasis were also detected, lymph node metastasis, venous vessel involvement (v2 or v3), and NPG type. Two findings, lymph node metastasis and NPG type, were chosen for prognostic factors, and patients were classified into three groups, patients with no factor, with one factor, and with two factors. The cumulative 5-year survival rates were 100% in the no factor group, 87.8% in the one factor group, and 50.0% in the two factors group. Therefore, nerve preserving operation is reasonable for patients with no prognostic factor, but it is neccessary for some patients with one or two prognostic factors to undergo more wide ly-mphadenectomy or more extended surgery such as non-nerve-sparing procedure.
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