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Volume 45, Issue 3
Displaying 1-17 of 17 articles from this issue
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Antitumor Effect of 5-Fu Administrated via the Portol VeinH. Kimitsuki1992 Volume 45 Issue 3 Pages 259-265
Published: 1992
Released on J-STAGE: December 03, 2009
JOURNAL FREE ACCESSThe effect of regnioal chemotherapy via the portal vein for prevention of liver metastasis from colorectal cancer was experimentally evaluated using a new murine liver metastasis model. BALB/c mice aged five to six weeks were laparotomised and murine "Colon 26" cell suspension (5, 000 cells) was injected into the portal circulation. Animals were divided into three groups ; portal vein regional chemotherapy, systemic chemotherapy, and control groups. The metastatic lesions were detected on the fourth day after injection of tumor cells by the microscope and all mice have visual metastatic lesions on the hepatic surface at the fourteenth day after injection of tumor cells. The number of macroscopic metastatic nodules developed on the liver surface was significantly less in the regional chemotherapy group (0.5±1.0) than the systemic chemotherapy (2.0±1.0) and control groups (8.9±3.4). Similarly, the number of microscopic metastasis lesion significantly decreased in the regional chemotherapy group. In addition, animal survival was prolonged in the regional chemotherapy group (48.8±8.3 days) as compared to the systemic chemotherapy (30.8±6.7 days) and control groups (19.8±1.8 days). Regional chemotherapy via the portal vein may have a potential to prevent liver metastasis from colorectal cancer.View full abstractDownload PDF (3431K) -
K. Tsujita, K. Funabashi, M. Watanabe, Y. Hasebe, S. Yamashita, K. And ...1992 Volume 45 Issue 3 Pages 266-272
Published: 1992
Released on J-STAGE: December 03, 2009
JOURNAL FREE ACCESSThe DNA content of five samples obtained from different sites in each of 67 colorectal carcinomas was measured by flow cytometry to study on intratumor heterogenity of nuclear DNA content.
Among the five samples of the same tumor DNA ploidy was discordant in 16 cases and the difference in the DNA index (DI) value was found in 11 patients with aneuploidy in all specimens taken from the same tumors. Therefore intratumor DNA heterogenity was observed in twentyseven of 67 cased (40.7 %).
DNA heterogenity was not associated with the location of the tumor, size, depth of tumorinvasion, lymphatic vessel invasion, lymph node metastasis, and stage. On the other hand, tumors with the presence of DNA heterogenity had significantly higher frequency of moderately differentiated adenocarcinoma, presence of venous invasion, and liver metastasis than those wdthout DNA heterogenity.
The incidence of tumor with s (a2) or si (ai), liver metastasis and advanced stage more than stage III was highest in the cases with aneuploidy in all samples and the presence of intratumor DNA heterogenity.
There was a good correlation between DI obtained from biopsy and resected specimen only when intratumor DNA heterogenity was not observed.View full abstractDownload PDF (383K) -
N. Fujimoto, M. Takano, T. Fujiyoshi, K. Takagi, M. Fujiyoshi, M. Kawa ...1992 Volume 45 Issue 3 Pages 273-281
Published: 1992
Released on J-STAGE: December 03, 2009
JOURNAL FREE ACCESSClinicopathological analyses were made on 14 laparotomized cases of carcinoid of the colon. Although the diagnosis is done by the color, form, hardness and biopsy, the existence in the submucosal layer makes the jedgement of the invasiveness difficult. As the result, the method of excision is decided by the size and the location. The lesion in the right colon is apt to be delayed in the diagnosis with the result that it tends to be operatively resected. As for the lesion in the rectum, it usually is resected with a colonofiberscope when the size is less than 1 cm. When the size is over 1 cm., it has to be resected locally, by perineal resection or by laparotomy. When the size is over 2 cm., it must be definitely resected by laparotomy. However, when it is between 1 to 2 cm. and the invasion is over submucosal layer, it has to be managed carefully because the lesion has the possibility of lymphatic matestasis.View full abstractDownload PDF (3165K) -
T. Shimazaki1992 Volume 45 Issue 3 Pages 282-291
Published: 1992
Released on J-STAGE: March 03, 2010
JOURNAL FREE ACCESSA cytotoxic subustance (s) was detected in culture filtrates of Bactero;des vulgatus isolated from patients with ulcerative colitis (UC) and healthy adults. Forty of 47 isolated from patients with UC and 22 of 38 -isolated from healthy adults exhibited cytotoxicity on one or more lines of tissue cultured TCMK-1, Hela-S3, HEp-2 and Intestine-407 cells. Culture filtrate of B. vulgatus strain IS-22-21 isolated from UC induced cytotoxic response on all of these cells. The broth culture (1±109/ml of bacterial cells) and culture filtrate of B. vulgatus IS-22-21 induced fluid accumulation and UC-like lesions in the ligated rabbit ileal loops. The cytotoxic activity of strain IS-22-21 was stable at 100°C for 15 min and not destroyed by treatment with Pronase or trypsin. This cytotoxicity was filtera-tative through a menbrane which retained substances of molecular weight over 1, 000. The cytotoxicity was decreased by extraction with diethylether and inactivated by adjusting the sample to pH 7.2. In organic acid analysis with gas chromatography/mass spectrometry of the culture filtrate of the strain IS-22-21, 3.8 mg of succinic acid per ml was detected. It was suggested that such a large quantity of succinic acid was one of the cytotoxic substance (s) and played the ethiological role of UC.View full abstractDownload PDF (4544K) -
Treatment for Relapse in Residual Liver after Hepatic ResectionN. Kikkawa, Y. Tsuchiya1992 Volume 45 Issue 3 Pages 292-296
Published: 1992
Released on J-STAGE: December 03, 2009
JOURNAL FREE ACCESSAlthough hepatic resection for metastatic colorectal carcinoma is now an accepted therapeutic option, most patients suffer a postoperative relapse. During the past 10 years, 74 patients (53 unilobar and 21 billobar, 51 synchronous and 23 metachronous) have undergone hepatic resection for colorectal carcinoma at Osaka National Hospital. Thirty-eight patients have shown relapse during this study, occurring in the liver in 29 patients, lung in 11 patients, locally in 6 patients, brain in 4 patients and so on. The relapse site in 16 out of 38 patients was the residual liver tissue alone (re-recurrence).
The treatment for these 16, re-recurrence cases was as follows. Laparotomy was performed on 7 patients, 5 of whom underwent repeat hepatic resection. Transarterial Chemoembolization (TACE) was performed on 8 patients. The other 6 patients had systemic chemotherapy alone, for reasons such as poor risk or multiple hepatic re-recurrence. Aggres-sive therapy such as repeat hepatic resection and / or TACE is very effective in some cases, but more detailed study about their efficacy is necessary.View full abstractDownload PDF (129K) -
M. Furukawa, T. Nakata, T. Kusano, T. Sakai, Y. Lin, K. Tashiro, S. Wa ...1992 Volume 45 Issue 3 Pages 297-303
Published: 1992
Released on J-STAGE: December 03, 2009
JOURNAL FREE ACCESSAlthogh familial incidence of Crohn's disease is very low in Japan, in our hospital two cases of this disease in siblings were found.
Case 1 : A 15-year-old male (younger brother). In March 1976 he had a pain in the ileocecal region and underwent appendectomy. However, the appendix was normal, and s a tumor was found in the ileocecal region. An upper GI series indicated a stricture and a fistulation in the terminal region of the ileum ; the patient was diagnosed as having Crohn's disease. A celiotomy was done and the ileocecal resion was resected. The excised specimen revealed a longitudinal ulcer in the ileum and a fistule in the mesentery. The patient has shown no signs of recurrence and is in good health today, 15 years after the operation.
Case 2: A 29-year-old male (older brother). The patient recieved appendectomy seven years ago (at age 22). He has admitted to our hospital in March 1988 with abdominal gain; and was given barium enema which revealed a stricture and a fistulation in the terminal region of the ileum, as well as a stricture in the sigmoid colon. As his young brother had Crohn's disease, we suspected it in this patient also. Resection of 150 cm of the ileum as well as the sigmoid colon were done. The excised ileum showed a longitudinal ulcer and skip lesions. The patient has shown no signs of recurrence, three years after the operation.
A study of the HLA antigen revealed that among, all the HLA antigen reported in Japan to have a correlation with Crohn's disease, the only BW-61 was in Case 2 (older brother).View full abstractDownload PDF (505K) -
Y. Seo, S. Arichi, M. Murakami1992 Volume 45 Issue 3 Pages 304-310
Published: 1992
Released on J-STAGE: December 03, 2009
JOURNAL FREE ACCESSCancer developing in a blind loop is extremely rare and only 4 cases have been reported in domestic literature. We reported a case of colon cancer developed in a blind loop, and pertinent literatures were reviewed.
A 68-year-old female, who underwent side-to-side ileo-transversocolostomy for occlusion of the terminal ileum when she was 16 years old, visited our hospital for exact examination of the gastro-intestinal tract without any subjective symptoms. Barium enema study revealed that the right side of the colon had remained as a blind loop, moreover a localized, nodulated, and elevated filling defect was discovered in the cecum, measuring 3 cm in diameter. Right hemicolectomy including the anastomosis with R, lymph node dissection was carried out and reconstruction was performed by end-to-end ileo-transversocolostomy. Histologically, the tumor revealed well differentiated adenocarcinoma and dignosed cecal cancer that developed nearby lower lip of Bauhin's valve. Grade classification was stage I (H0. P0, pm, n (-), ly0, v0). The patient has been in good health without a sign of recurrence for 1 year after operation.View full abstractDownload PDF (543K) -
K. Maeda, M. Hashimoto, H. Nishibori, Y. Murayama, M. Sano, H. Katai, ...1992 Volume 45 Issue 3 Pages 311-315
Published: 1992
Released on J-STAGE: December 03, 2009
JOURNAL FREE ACCESSAn early rectal cancer showng a granular elevation 11 cm in length was presented.
Histologically, a well differentiated adenocarcinoma accompaning severe inflammtory cell infiltration at its margin invaded mainly in the submucosal layer. No lymph node involve-ment and slight vessel invasion (ly1, vo) was confirmed. Adenomatous component was not observed in the resected specimen. Islet normal mucosa was shown at the center of cancer tissue. Speciality of this early cancer showing a distinguished horizotal spread and inflamma-tory change was discussed according to the literature. It is suggested that a well differen-tiated adenocarcinoma in the colorectum showing a distinguished horizontal spread and inflam-y matory change can be a more low malignant biologically. This case can be an early case of the low malignant group.View full abstractDownload PDF (417K) -
T. Ochiai, K. Shimoda, T. Suzuki, K. Yoshii, K. Shigematsu, M. Moriwak ...1992 Volume 45 Issue 3 Pages 316-320
Published: 1992
Released on J-STAGE: December 03, 2009
JOURNAL FREE ACCESSThe colon is the least commom site for leiomyosarcoma throughout the entire gastro-intestinal tract. We report a case of leiomyosarcoma of the Sigmoid colon. The case was a 66-year-old man complaining of abdominal fullness. Preoperative diagnosis was mesenteric tumor of sigmoid colon by barium enema, CT scan, angiography and colonoscopy. Tumor resection with sigmoid colon and lymphonodi dissection were per-formed. The tumor, 7.0×6.0×6.5 cm in size, of extralunimal type, was located at the muscular layers of the sigmoid colon.
To our knowlodge, 68 cases, including the present case, of leiomysarcoma of the colon have been previously reported in Japan.
A disucussion of these cases is also presented in this report.View full abstractDownload PDF (383K) -
K. Tashima, T. Kitaichi, Y. Fukuta, Y. Shimada, Y. Kuge, H. Oguchi, M. ...1992 Volume 45 Issue 3 Pages 321-325
Published: 1992
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSA 49 year old woman was referred to our hospital for tumor protrusion beyond anus. Under spinal anesthesia, the tumor was inserted through the anus. According to barium enema and colonofiberscopy examination, this tumor was present on the transverse colon, but it was not clear where this tumor developed. On laparotomy, actually this tumor developed on ileocaecal region and seemed like a malignancy so that the ileocaecal region and ascending colon was resected. On postoperative pathological study, it was understood that the tumor was benign lipoma developed on the ileum. Her postoperative course was very good and discharged 21 days after operation.
Ileal tumor rarely protrudes beyond the anus.View full abstractDownload PDF (2997K) -
T. Inoue, N. Ootashiro, H. Ankou, M. Yoshida, A. Ootashiro, I. Shimura ...1992 Volume 45 Issue 3 Pages 326-329
Published: 1992
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSA Case of Acute Hemorrhagic Rectal Ulcer with Recto-vaginal Fistula.
In this case, the patient was 65 y. o. that had a history of neurosurgical operation twice nn anothec hospital, then appeared to be bleeding from anus and vagina after the operation, and transfered to our hospital.
In colonoscopical findings, the rectovaginal fistula was recognized just at the dental line surround in map-shaped ulcer in the rectum. Then we constructed sigmoid colostomy and the clinical course was getting better day by day.
In this case, we diagnosed the acute hemorrhagic rectal ulcer, though there is no case report of the rectal ulcer forming recto-vaginal fistula in our country and because this is an extraordinary case.
We will report it with some consideration to utilizing the references.View full abstractDownload PDF (2838K) -
M. Imamura, A. Nitta, N. Takahashi, H. Yamauchi, Y. Kunii, M. Nakajima1992 Volume 45 Issue 3 Pages 330-335
Published: 1992
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSA 66-year-old female entered the hospital in January 1991 complaining of painful anal bleeding and pruritus ani. Perianal rash had been present for a year, and treated unsuccessfully with topical steroids. Proctoscopic examination revealed several small sessile polyps 4 to 5 cm from the anal verge. Plasma levels of tumor markers, such as CEA, CA 19-9, and CA 125, were markedly elevated. Abdominal both ultrasonography and CT scanning demonstrated multiple tumors in the liver. Under spinal anesthesia, polypectomy and incisional biopsy of erythematous perianal skin lesion were performed. A needle biopsy of the liver tumor was also done under ultrasonographic guidance. Pathological examination of these specimens showed pale vacuolated Paget's cells, which stained positive with alcian blue for mucoid material, and contained CEA-positive material in the cytoplasm.
Perianal Paget's disease associated with anorectal carcinoma is rare, and only fifteen cases have been reported in Japan. This case had distant metastasis to the liver, and local palliative management using 5-fluorouracil ointment and suppository was performed.View full abstractDownload PDF (7726K) -
K. Shinohara, T. Konishi, Y. Ushicokohji, G. Yoshino, S. Yumoto, K. Sa ...1992 Volume 45 Issue 3 Pages 336-340
Published: 1992
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSA biochemically modulated chemotherapy with Leucovorin (LV) and 5-Fluorouracil (5 FU) was performed in 7 cases of distant metastasis with colorectal cancer. LV 20 mg/m2 was administered as a bolus infusion followed by administraton of 5 FU 425 mg/m2 daily for 5 days.
Treatment was repeated every 4 weeks. For liver metastasis, drugs was administered through hepatic artery from totally implantable infusion pump. For multi-organ-metastasis, they were administered by systemic infusion.
The response rate was 43%, and side effect was minimum except leucocytopenia in one case. LV/5 FU therapy is effective for the treatment of metastasis of colorectal cancer.View full abstractDownload PDF (2686K) -
M. Ino, T. Tanaka, S. Takeuti, H. Tateoka, M. Yokoyama, O. Matsuura, A ...1992 Volume 45 Issue 3 Pages 341-345
Published: 1992
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSFor 10 years from 1982 to 1991, 30 cases of colorectal camcer, infiltrating to the proper muscle layer, were examined and evaluated on the basis of clicopathological findings.
Pm colorectal carcinoma was classified into two groups according to the depth of invasion into the circular muscle layer (C type) and longitudinal muscle layer (L type).
Most of the pm colorectal carcinomas were located in the rectum (66.7 %). The incidence of pm colorectal carcinoma, according to macroscopic classification, showed that the elevated type had a higher percentage (66.7 %) than the ulcerative type (33.3 %). As the carcinoma invaded deeper into the proper muscle layer the incidence of vascular invasion and lymph node metastasis tended to increase. Vascular metastasis of L type (92.9 %) was higher than that that of C type (43.8 %). Lymph node metastasis of L type was 35.7 % and C type was 31.3%.
The recurrence of the pm colorectal carcinoma was seen in 4 cases.
Two cases were locale recurrences, one was lung metastasis, one was multiple bone metastasis.View full abstractDownload PDF (302K) -
A. Tsunoda, M. Kawamura, H. Yoshizawa, K. Nakao, M. Iseki, K. Marumori ...1992 Volume 45 Issue 3 Pages 346-351
Published: 1992
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSForty two cases of colorectal carcinoma, infiltrating to the proper muscle layer, were experienced during the 10 years from 1981 to 1990, and were evaluated on the basis of clinicopathological findings.
The incidence of pm colorectal carcinoma according to macroscopic classification showed that the elevated type disclosed 24 cases and the ulcerative type 18 cases.
The incidence of vascular invasion in the ulcerative type was significantly frequent compared to that in the elevated type. Lymphnode metastasis in the elevated type (9 %) was less frequent than that in the ulcerative type (28 %). It is indicated that R2 operation preserving normal physiological function is reasonable for the elevated type, while more radical surgery is indicated for the ulcerative type.View full abstractDownload PDF (362K) -
1992 Volume 45 Issue 3 Pages 352-360
Published: 1992
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSDownload PDF (799K) -
1992 Volume 45 Issue 3 Pages 361-375
Published: 1992
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSDownload PDF (1250K)
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