Case 1: A 62-year-old male was undergoing the Cape-OX regimen as adjuvant chemotherapy for stage IIIa ascending colon cancer. A blood test done before the second cycle of chemotherapy revealed chyle and triglyceride was 1,037 mg/d
l. We suspected hypertriglyceridemia due to capecitabine. After discontinuing capecitabine, the hypertriglyceridemia resolved.
Case 2: A 62-year-old male was undergoing the capecitabine regimen as adjuvant chemotherapy for high-risk stage II rectal cancer. A blood test done after the second cycle revealed chyle. Triglyceride was 1,058 mg/d
l, and we suspected hypertriglyceridemia due to capecitabine. After discontinuing capecitabine, the hypertriglyceridemia resolved.
Hypertriglyceridemia due to capecitabine is rare, but it is a high-risk factor for acute pancreatitis and must be considered.
Triglyceride level must be followed closely during the use of capecitabine.
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