The effects of anti-Habu-serum injection on the local and systemic pathological changes produced by Habu venom injection were histopathologically examined, using male guinea pigs as experimental aniamals.
Injection 1 ml serum for 1 mg venom, or 5 to 10 ml serum for 5 mg venom, both local and systemic pathological changes were repressed, if the serum injection was administered without delay. Even when the changes were produced, they were slight in degree.
When the amount of the serum used was insufficient-1 or 2 ml for 5 mg venom-the serum was not very effective; it could repress neither local nor systemic pathological changes. However, by comparison with the untreated control cases, life of the animals was prolonged by the use of serum.
Generally speaking, the characteristic systemic pathological changes produced by Habu venom consist in circulatory deficiency, which is due to the toxicity of the venom working either directly of indirectly. Immediate administration of the serum is recommended; but when the symptoms are serious, some allopathic treatment for shock must not be neglected in addition to the serum therapy.

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われわれは胃癌の疫学的検索により, Caが胃癌発生に対して抑制的な影響を及ぼすものと推論した.
従つてかかる推論を実証するため, 強いては積極的な癌予防の解決のために独自な考えで一連の「癌とCaに関する実験的研究」をすすめ, Ehrlich癌発育は相当量のCa含有食品投与により抑制されることを明かにし, これはCaが癌細胞増殖の代謝過程にある核蛋白合成に阻害作用を及ぼすためであろうと推定した.また胃癌発生の素地をなすと考えられる高濃度食塩含有食品による胃粘膜障害の発生はCa添加により阻止し得ることを明かにし, 癌に対するCaの影響の重要性を指摘してきた.
その後, 未だ系統的研究に乏しいと考えられる癌に及ぼす電解質の影響を広範囲に検索し, 同時に癌に対するCaの抑制効果の作用機序を明かにするため, 可移植性のEhrlich癌を用いて一般的な各種電解質 (Mg, Na, K, Ca) はその増殖ないし移植性に対して如何なる影響をもたらすかを実験的に検討し, さらにEhrlich癌細胞は各種電解質により如何に変化するものかを細胞学的に比較検討して興味ある2, 3の知見を得た.
なお本研究の一部は逐次速報してきたがその詳細をまとめて明示し, さらに癌に対するCaの抑制効果について考察を加えた次第である.

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Recently numerrus reports have appeared on the surgical corection of mandibular prognathism, and various operative procedures for this deformity presented both in home and abroad. I used a modification the procedure, initiated by Kostecka and Lindermann, who resorted to osteotomy above the mandibular foramen on a horizontal plane In order to obtain broader contact surface and to enhance bony union, we recommended that the osteotomy line ehon be oblique in the asccnding ramus a and that the osteotomy line should be oblique in the ascending ramus and that the operation should be performed by the subcutaneous closed method with a Gigli saw and a special type K rgel needle. The postoperative treatment is essentially the same as in mandibular fractures.
The method described in this article permits all the teeth to be placed into occlusion, and the patient is given a good, functional jaw as well as improved physiognomy.
Moreover, the technique is simple, operative time short (30 to 40 minutes), and facial scars are absent, which are considered enough to recommend this method.

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In order to elucidate the mechanism concerning the development of arterial thrombosis, various blood coagulation factors and plasma 17-OHCS levels were determined in 18 cases of hypertension, 10 cases ob cerebromalacia, 13 cases of angina pectoris, 13 cases of myocardial infarction and 20 normal subjects simultaneously. Furthermore, effects of single or daily administration of prednisolone on the blood coagulation were observed in 17 cases with various diseases. The results obtained were as follows :
1. Shortening of prothrobinm time, increase in prothrombin concentration or factor 7 activity were observed in half of 10 patients in 69 hours after single oral dose of 25 mg of prednisolone. The daily administration of prednisolone was followed by similar changes in 6 out of 7 cases.
In this case, an increase in factor 5 activity was obtained in 6 cases, although no remarakable change was found after single dose.
2. Plasma 17-OHCS levels were significantly increased in patients with hypertension, angina pectoris, cerebromalacia or myocardial infarction. The levels tended to be higher in the latter two diseases, especially in fresh cases.
3. Significant increase in factor 7 activity was observed in all these patients, while significant increase in factor 5 activity was seen only in patients with myocardial infarction. In patients with cerebromalacia or myocardial infarction, one stage prothrombin time was significantly shortened. No significant increase in prothrombin concentration was found in all these patients. Changes in these blood clotting factors were more remarkable in patients with arterial thrombosis. From the clinical observation, these changes seemed to be related to the development of arterial thrombosis.
4. There was highly significant inverse relationship between 17-OHCS levels in plasma and one stags prothrombin time. Similarly, significant relationship was observed between 17-OHCS levels and factor 5 or 7 activity. There was no correlation between 17-OHCS levels and prothrombin concentration.
From the results above described, it is concluded that adrenocotrical hyperfunction may be responsible for an increase in blood coagulability and the development of thrombosis.

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