With increased application of radioactive pharmaceuticals, exposure of patients to radiation has attracted grave attention. Especially when mercuric Preparations are used, the kidney is exposed to a large dosis. To eliminate the radioactive substance as early as possible after receiving diagnostic informations is one of the measures to relieve the patient from radiation injury.
Male dd N mice were used as experimental animals. Tracer doses of various radioactive mercuric preparations were intraperitoneally injected to them, and radioactivity was daily measured for 3 days with animal bodies and their excrements, using the whole-body animal counter, and at 3 days radioactivity of
203Hg in various organs was determined with the well-type scintillation counter. From immediately after the radioisotope injection, various drugs (in doses varying by toxicity) were given every 24 hours, that is, once daily for 3 days and effects on the retention, excretion and organ distribution of
203Hg were examined to evaluate the eliminating activities.
Drugs that decreased the retention of
203Hg-MHP and accelerated its urinary excretion were BAL, mercaptoacetic acid (MAA), 2-mercaptopropionyl glycine (MPG), DL-penicillamine (Pen.) and GSH. Furosemide conversely increased the retention. L-CySH, Rongalite and EDTA elicited no change.
Drugs that were effective for elimination of
203Hg chlormerodrin were MPG, MAA, and Pen. BAL lowered
203Hg concentration in the kidney, but elevated it in the liver and brain. GSH decreased
203Hg in the brain and pancreas, but did not change its amount in the other organs. Furosemide increased
203Hg in the liver and pancreas. EDTA, DTPA and Rongalite exerted no effect.
Drugs that were effective for eliminatin of
203Hg-Salyrgan were MPG, GSH, Pen and Rongalite. Furosemide and BAL increased the retention.
All the mercuric compounds were increased in body retention under fasting condition. Effect of eliminating them differed in different compounds.
The distribution and excretion of these mercuric compounds administered s.c. or i.p. into Ehrlich ascites cancer-bearing mice were also examined.
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