巻号一覧
後続誌
31 巻 (1981)
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31 巻, 4 号
選択された号の論文の8件中1～8を表示しています
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前立腺肥大結節のアンドロゲン依存性とアンチアンドロゲン剤の応用志田 圭三1981 年 31 巻 4 号 p. 227-239
発行日: 1981/08/15
公開日: 2009/10/15
ジャーナル フリーPDF形式でダウンロード (2351K) -
小林 寛1981 年 31 巻 4 号 p. 241-259
発行日: 1981/08/15
公開日: 2009/10/15
ジャーナル フリーラットにビタミンA (Chocola A) を投与し (1回15,000i.u.を隔日に7回筋肉内注射), 肝臓の伊東細胞 (脂肪摂取細胞) の脂質滴が増加した状態の材料を使用してフリーズ・レプリカ法を試み, 超薄切片像と比較検討した.
レプリカ像では伊東細胞の多くの脂質滴は平滑な凸面或は凹面をもって割断され, しばしば割断面上に1～2層或はそれ以上の薄膜が重層して現われる.また中心部から周辺部まで同心円状の層板で充満した滴もみられる.一方脂質滴の内部がほぼ水平に割断された場合, 不規則でわずかな凹凸のある粗な面を呈する脂質滴もある.その他, 滴の表層部に層板構造が現われ, 他の部分は粗な面を呈するものや, 1-3個の同心円状の層板構造をもった小球が1個の脂質滴の中に見出されるものなど種々の像が観察され, これらのレプリカ像にそれぞれ対応すると思われる像が超薄切片像でも確認された.脂質滴が相接して融合する際, 滴の表層部の薄膜が互に融合し, 連続する像や, 一方の滴から層板構造をもった棍棒状の突起が他方の滴の内部に嵌入するように延び出すものがレプリカ像と超薄切片像の双方で認められた.
燐脂質に関する諸学者の生化学的, 形態学的研究の成果を考え合せると, 伊東細胞の層板構造をもった脂質滴には燐脂質が含まれることが推測され, ビタミンA (レチノール) は同心円状の層板構造をつくる燐脂質分子の問に配列して貯蔵されることが示唆される.
伊東細胞の核膜孔の分布は肝細胞の核膜孔の数よりも少なく疎である.Kupffer細胞の核膜孔は更に少なく, 少数個のものが小群をつくって分散する傾向がみられる.伊東細胞の細胞膜には多くのpinocytotic vesicleの小陥凹がみられ, この周囲に膜内粒子が小さい集団として認められることがある.またP面における膜内粒子がところどころで密に凝集し, 不規則な小集塊をなして散在するのが観察された.抄録全体を表示PDF形式でダウンロード (14136K) -
大山 碩也1981 年 31 巻 4 号 p. 261-266
発行日: 1981/08/15
公開日: 2009/10/15
ジャーナル フリーThe author, having measured with time cyclic nucleotides, in the plasma of normally mature neonates, have earlier published a report on the possibility of cyclic nucleotides being involved in the mechanisms of adaptability after birth. This time, the following findings are obtained as cyclic nucleotides in the plasma and organs have been measured with time.
1) Both cAMP and cGMP levels in the plasma of naturally delivered rats rapidly dropped immediately after their birth, and the value in the sixth hour proved significantly lower than the value registered immediately after birth. Both cAMP and cGMP on the sixth day were significantly affected by stress at the time of blood sampling.
2) The lung turned out to be the only organ in which the cAMP level in the sixth hour was significantly lower than that which had been marked immediately after birth. No significant difference was noted in respect to the alimentary tract, kidney and muscles, whereas a rise in the cAMP level was noted for the liver. On the other hand, the cGMP levels proved significantly lower in the sixth hour for the five organs than those immediately after birth, and this coincides with the pattern of changes in the plasma. The cGMP levels for the five organs in the sixth day are the same as or lower than those in the sixth hour.
Given these findings, it might be concluded that cyclic nucleotides are involved in the mechanisms of adaptability after birth.抄録全体を表示PDF形式でダウンロード (807K) -
今井 強一, 山中 英寿, 中井 克幸1981 年 31 巻 4 号 p. 267-275
発行日: 1981/08/15
公開日: 2009/10/15
ジャーナル フリーLarge quantities of zinc are found in the human prostate, which increase in prostates with benign prostatic hypertrophy, excluding levels found in prostates with carcinoma. Zinc concentration in the outer capsular zone is equal to that found in the prostate with benign prostatic hypertrophy. Determination of zinc concentration in the prostate is a usefull method for the study of prostatic carcinoma.
In our experiment, zinc concentration was greatest in the cytosole fraction (65%), the crude nuclei fraction also contained significant amounts. Zinc distribution in the extra-and intra-nuclei fraction were determined by Triton X 100 treatment for the crude nuclei fraction.
Zinc in the prostate is of two types : binding zinc and free zinc. After dialysis treatment for 24 hours, binding zinc made up approximately 60% of the total zinc in the cytosole fraction and the ratio (binding zinc/free zinc) did not change for over 24 hours. Sephadex G 25 column chromatography showed that binding zinc was bound to protein.
Arginase activity in the cytosole fraction was inhibited by Zn++, This inhibitory action reflected Zn++ concentration and this was prevented or reversed by Mn++.抄録全体を表示PDF形式でダウンロード (1391K) -
村谷 貢, 中村 卓次, 新井 昌明, 中野 眼一, 木村 浩, 小川 晃男, 加藤 良二1981 年 31 巻 4 号 p. 277-283
発行日: 1981/08/15
公開日: 2009/10/15
ジャーナル フリー実験胃癌の研究は, 1967年杉村らがラノト腺癌をN-Methy-N'-Nitro-N-Nitrosoguamdme (MNNG) の経口投与により発生せしめたことに端を発し, 1974年栗原らのN-Ethyl-N'-Nitro-N-Nitrosoguamidime (ENNG) の経口投与によるイヌ胃癌の発生実験の成功により, 実験イヌ胃癌作製工方法はほぼ完成された.現在実験胃癌の研究は, その治療実験へと進められている.しかし癌発生部位を的確に予想出来ない従来の作製方法は, 治療実験を行い病変の変化を経時的に観察する上で改善の余地を残している.
今回われわれは, ENNG含有ペレットをイヌ胃粘膜下に埋没しさらにENNGを経口投与して埋没部に他部位より高頻度に癌が発生する事を期し, 加えて発癌期間を短縮せしめ, これを治療実験モテルにする目的で実験を行い, 若干の知見を得たので報告する.抄録全体を表示PDF形式でダウンロード (2793K) -
小堀 清久, 大根田 玄寿, 鈴木 慶二, 茅野 真男1981 年 31 巻 4 号 p. 285-294
発行日: 1981/08/15
公開日: 2009/10/15
ジャーナル フリーA 61-year-old man with marked eosinophilic leukocytosis who complained of gait disturbance and dementia was presented. The clinical studies and autopsy findings were compatible with eosinophilic leukemia.
At autopsy, in addition to marked enlargement of the liver and spleen, there were slight enlargement of the lymph nodes. Marked eosinophilic infiltration of the bone marrow, liver, spleen and lymph nodes was observed by light microscope.
Most of the eosinophils had mature type nuclei being sometimes hypersegmented, and intracytoplasmic vacuoles. Eosinophilic myelocyte and metamyelocyte were also found in the peripheral blood. Upon electron microscopic study of the eosinophile, the granules exhibiting various stages of development were observed in mature type eosinophil with multi-lobular nucleus. The eosinophile exhibited asynchronous maturation between the nucleus and cytoplasm.
In addition to mural thrombus of both ventricles, there were multiple thrombosis of small arteries and arterioles. Consequently infarctions of the heart, spleen, brain and kedneys, and ulceration of the colon and small intestine occurred in this case. It is considered that both thromboembolism from the mural thrombus in the heart and disseminated intravascular coagulation due to eosinophilic leukemia may be the causes of the multiple thrombosis.抄録全体を表示PDF形式でダウンロード (6868K) -
六本木 隆, 饗場 庄一, 塩崎 秀郎, 松本 弘, 佐藤 晴男, 中島 博, 桜井 達夫, 仲村 匡也, 金子 達夫1981 年 31 巻 4 号 p. 295-299
発行日: 1981/08/15
公開日: 2009/10/15
ジャーナル フリーAccording to previous literature, about 230 cases of “limy bile” have been represented by 1980 in Japan.
But it is extremely rare to find the “limy bile” cases in a lot of the operative cholelithiasis.
In our hospital, 434 cases have been diagnosed cholelithiasis and operated in the past ten years., in these, we have experienced two cases of “limy bile” (A 24-year old female and a 25 year old female) (0.46%).
It is possible to diagnose “limy bile” preoperatively by means of radiological findings and ultrasonography.
Two cases were presented and literal study were added.抄録全体を表示PDF形式でダウンロード (1849K) -
5 血管輪と食道造影三橋 多佳子, 平敷 淳子, 石橋 春美, 三橋 将人, 黒梅 恭芳1981 年 31 巻 4 号 p. 301-303
発行日: 1981/08/15
公開日: 2009/10/15
ジャーナル フリーPDF形式でダウンロード (1191K)
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