1. The retrograde degeneration in the anterior thalamic nuclei of the dog following localized ablations of the limbic cortex indicates that the nucleus anteromedialis projects mainly to the anterior cingular region, the nucleus anteroventralis to the posterior cingular region, and the nucleus anterodorsalis to the retrosplenial region.
2. By ablation of the medial cortex above the sulcus splenialis of the dog, the nucleus anteroventralis and nucleus anterodorsalis, especially the former, show retrograde degeneration.
3. When the lateral cortex of the cer e bral hemisphere is almost completely ablated unilaterally in adult and young dogs, considerably severe changes are found in the nucleus anteroventralis, nucleus anterodorsalis and nucleus anteromedialis pars dorsolaterals. This fact may indicate that these nuclei project also to the lateral cortex.
4. On studying the Mar c hi preparations of the cat in w hich the electrolytic lesion has been made in the dorsolateral part of the nucleus anteroventralis, the degenerated fibers can be traced mainly to the posterior cingular region, a part of the anterior cingular region and the anterior part of the retrosplenial region. In addition to these regions, a small number of degenerated fibers can be followed also to the gyrus splenialis, gyrus suprasplenialis, gyrus lateralis and gyrus suprasylvius medius.
5. The cortical projection fields of t h e anterior nuclei overlap more extensively than generally assumed. These projection fields overlap not only with each other, but also with the other projection systems.
6. From the above-mentioned findings it may be concluded that the anterior thalamic nuclei send fibers mainly to the limbic cortex, but a few fibers run dorsalward to the medial cortex above the sulcus splenialis, and the lateral cortex, especially the gyrus lateralis and the gyrus suprasylvius medius.
This investigation was supported in part by grant for scientific research from the Department of Education of the Japanese Government.
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