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Volume 91 (2014)
- Issue 4 Pages 83-
- Issue 3 Pages 49-
- Issue 2 Pages 25-
- Issue 1 Pages 1-
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Volume 91, Issue 2
Displaying 1-4 of 4 articles from this issue
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CONTENTS
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Hisashi OSHIRO2014 Volume 91 Issue 2 Pages 25-28
Published: 2014
Released on J-STAGE: December 10, 2014
JOURNAL FREE ACCESSThe elucidation of the pathogenesis of human diseases requires increasingly relevant and rigorous animal models. Therefore, investigators must select an appropriate mammalian model. Mice and rats are indispensable in the understanding of the mechanisms of human diseases, but other non-rodent mammals are required in certain situations. The rabbit is one such species. The rabbit exhibits greater biological similarities to humans than the mouse or rat, and the rabbit VX2 allograft cancer model has been used in a broad range of oncological studies, such as stromal responses, metastatic behaviors and therapeutic effects. Cancer cells in this model proliferate in a host rabbit that maintains a natural immunity, which makes this model attractive and unique. However, these examples constitute only a small number of advantages of a rabbit model. Numerous reports suggest that the rabbit is an attractive cancer-bearing animal model for the study of cancer metastasis and the lymphatic system. I briefly review the relevant medical literature and compare the rabbit lymphatic system with mice, rats and humans.View full abstractDownload PDF (662K) -
Kouji YAMADA, Kazuhiro NISHII, Kazuyoshi SAKAI, Toshio TERANISHI, Mamo ...2014 Volume 91 Issue 2 Pages 29-36
Published: 2014
Released on J-STAGE: December 10, 2014
JOURNAL FREE ACCESSOsteoporosis is leaving bones more fragile and susceptible to fracture. It has a massive impact, both physically and mentally, markedly diminishing quality of life. A new form of therapeutic exercise or physical therapy that mitigates the abrupt decrease in bone density in postmenopausal women must quickly be developed to avoid those problems. In this study, ovariectomy (OVX) mice were used as models to simulate the decrease in bone density observed in postmenopausal women. Physical therapy via a shaking stimulus, in the form of moving a platform that rotates in a roughly circular motion in the horizontal plane, was studied as a way to prevent the decrease in bone density of the lumbar vertebrae by analysis of bone histomorphometry, a feat that the stimulus from conventional therapeutic exercise and physical therapy have failed to achieve. Comparison of the stimulus/ovariectomized (+/+) group with the -/+ group indicated significant increases in ES (P < 0.01), N. Mu. Oc (P < 0.05), OV (P < 0.05), O. Th (P < 0.01), and L. Th (P < 0.01) in the +/+ group. If this finding is used clinically, we believe that it could lead to therapy that would prevent compression fractures of the lumbar vertebrae.View full abstractDownload PDF (3281K) -
Michiya UTSUMI, Keiichi MORIGUCHI, Akiko KATO, Hatsuhiko MAEDA, Norika ...2014 Volume 91 Issue 2 Pages 37-43
Published: 2014
Released on J-STAGE: December 10, 2014
JOURNAL FREE ACCESSWe qualitatively and quantitatively investigated the parathyroid glands of golden hamsters aged 6, 12, 18, 24 and 30 months. Percent area of rER in the parathyroid gland in golden hamsters at 24 months of age was significantly higher when compared to 6 and 12 months of age, and the percent area at 30 months of age was significantly higher when compared to 12 months of age, but there were no significant differences between 24 and 30 months of age. Percent area of the Golgi apparatus at 24 and 30 months of age was significantly higher when compared to 6, 12 and 18 months of age. Ultrastructurally, we believe that in the parathyroid gland of the golden hamster, synthesis and release of parathyroid hormone increase gradually from 6 to 24months of age and are maintained from 24 to 30 months of age.View full abstractDownload PDF (5713K) -
Jun YAN, Yoshie NAGASAWA, Masato NAKANO, Jiro HITOMI2014 Volume 91 Issue 2 Pages 45-48
Published: 2014
Released on J-STAGE: December 10, 2014
JOURNAL FREE ACCESSA variation artery was observed in a Japanese cadaver. The celiac and superior mesenteric arteries arose from a common trunk (also referred to as the celiacomesenteric trunk), but not from the abdominal aorta, respectively. From the common trunk, the common hepatic artery was distributed in the right part of the liver, and the left hepatic artery arose from the left gastric artery, which also arose from the common trunk. The left inferior phrenic artery arose from the common trunk, but the right inferior phrenic artery arose from the right middle suprarenal artery. This information regarding the branch pattern in this variation artery is useful for clinical examination and treatment.View full abstractDownload PDF (1328K)
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