Japanese Journal of Medical Science and Biology
Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISSN-L : 0021-5112
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Volume 29, Issue 6
Displaying 1-4 of 4 articles from this issue
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  • SOME ENDOCRINE ASPECTS OF THE THYMUS GLAND
    LOUIS V. CASO
    1976 Volume 29 Issue 6 Pages 289-321
    Published: 1976
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.29.289
    JOURNAL FREE ACCESS
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  • IMMUNOGENICITY OF LYSOZYME DERIVATIVES LIPID-CONJUGATED TO VARIOUS DEGREES IN MICE TREATED WITH AND WITHOUT CYCLOPHOSPHAMIDE: DISSOCIATION OF DELAYED-TYPE HYPERSENSITIVITY AND HELPER FUNCTION
    ASATO KOJIMA, MASANOBU SUGIMOTO, YASUYUKI EGASHIRA
    1976 Volume 29 Issue 6 Pages 323-333
    Published: 1976
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.29.323
    JOURNAL FREE ACCESS
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    Lysozyme and a series of its lipid-conjugated derivatives without adjuvant were examined in mice for their abilities to induce delayed-type hypersensitivity (DTH), helper T-cell activity, and antibody formation. In addition, the effect of cyclophosphamide (CY) on the immune responses was assessed in mice immunized with these lysozyme derivatives.
    Precipitated lysozyme without lipid conjugation was a good inducer of both antibody and DTH responses. Lipid conjugation to lysozyme to intermediate degrees readily caused the failure only in inducing the antibody response. As lysozyme was lipid-conjugated more heavily, DTH response was also reduced and finally abolished. In contrast, the helper activity was little affected by any degree of lipid conjugation. These results indicate that the helper T-cell activity was dissociated from both DTH response and the antibody production. CY pretreatment extensively enhanced DTH response induced by such lipid-conjugated derivatives that failed to induce antibody response. Furthermore, CY pretreatment in doses in a wide range enhanced not only DTH response but also antibody formation. It is, therefore, concluded that the enhancement of DTH response by CY does not necessarily entail suppression of antibody formation.
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  • PRODUCTION AND PROPERTIES OF θ-TOXIN OF CLOSTRIDIUM PERFRINGENS WITH SPECIAL REFERENCE TO LETHAL ACTIVITY
    SACHIKO SODA, AKIHARU ITO, AKIO YAMAMOTO
    1976 Volume 29 Issue 6 Pages 335-349
    Published: 1976
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.29.335
    JOURNAL FREE ACCESS
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    θ-Toxin of Clostridium perfringens produced in a synthetic medium showed high toxicity. The mouse was killed with 5-10 hemolytic units of the toxin. Neutralization experiments showed that lethal and hemolytic activities were due to the same toxic entity. The amount of θ-toxin expressed in lethal activity reached more than 30% that of α-toxin in the synthetic medium SM67. Although the activities of α- and θ-toxins were not additive in terms of LD50, increase in the ratio of θ-toxin to a-toxin resulted in reduction of the survival time of the mouse injected with a lethal dosis of the mixture of the two toxins when compared with a-toxin alone. Unlike those produced in other media, the hemolytic and lethal activities of θ-toxin produced in the synthetic medium was not activated by reduction with thioglycollate, even after partial purification. In other respects, the toxin was not different significantly from those reported in the past. The toxic form was detected also in complex medium. It was suggested that θ-toxin may be produced as a nascent entity.
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  • KILLING EFFECT OF NORMAL PERITONEAL EXUDATE CELLS IN GUINEA PIGS ON MICROFILARIAE OF DIROFILARIA IMMITIS EVOKED BY PASSIVE TRANSFER OF IMMUNE HUMORAL FACTOR
    TAKATOSHI KOBAYAKAWA, SHUN SHINBO, HIROSHI ISHIYAMA, KAZUSHIGE MASUDA
    1976 Volume 29 Issue 6 Pages 351-357
    Published: 1976
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.29.351
    JOURNAL FREE ACCESS
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    Parasiticidal activity of normal peritoneal exudate cells on microfilariae of Dirofilaria immitis in diffusion chambers implanted into normal guinea pigs was evoked by intraperitoneal passive transfer of anti-D. immitis serum. The immune serum was fractionated into supernatant and sediment by ammonium sulfate precipitation. The parasiticidal effect was reproduced with the supernatant and, to a less extent, with the sediment. Anti-D. immitis serum from the animals sensitized 5 days before was also effective in this respect. From these results it can be concluded that the factor responsible for the phenomenon is some other factor (s) than the antibody. In addition, the in vitro cytotoxicity test demonstrated an enhanced Mf-killing activity of sensitized peritoneal exudate cells by adding with anti-D. immitis serum.
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