Japanese Journal of Medical Science and Biology
Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISSN-L : 0021-5112
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Volume 34, Issue 5
Displaying 1-4 of 4 articles from this issue
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  • ABO BLOOD GROUP ACTIVITIES IN HUMAN ALBUMIN PREPARATIONS
    JUNICHI YASUDA, HARUICHI SAITO, JUNICHI OZAKI, SADAO ASAKAWA
    1981 Volume 34 Issue 5 Pages 271-279
    Published: 1981
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.34.271
    JOURNAL FREE ACCESS
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    By using hemagglutination-inhibition technique, A and B blood group activities were demonstrated in all of the tested batches of Plasma Protein Fraction and Human Serum Albumin prepared by one manufacturer in the period of 1975-1978; whereas all the tested batches prepared by other manufacturers were found to be free of blood group activities. With some batches of Plasma Protein Fraction prepared by the above-mentioned manufacturer, the presence of A blood group activity was confirmed by the anti-A response in immunized rabbits.
    The blood group activities were localized in earlier fractions in Sephadex G-200 gel filtration analysis. The active principles were resistant to boiling for one hour. They were recovered in the aqueous phase by chilled buthanol treatment and could not be extracted with chloroform-methanol.
    These results seem to suggest that the blood group active principles detected in the albumin preparations are more likely of water-soluble glycoprotein nature than being glycosphingolipids.
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  • ACUTE EFFECTS OF CADMIUM ON DELAYED-TYPE HYPERSENSITIVITY IN MICE
    ASATO KOJIMA, SHIN-ICHI TAMURA
    1981 Volume 34 Issue 5 Pages 281-291
    Published: 1981
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.34.281
    JOURNAL FREE ACCESS
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    A single exposure of mice to cadmium resulted in suppression of the induction of primary delayed-type hypersensitivity (DTH) responses as well as memory T-cell and suppressor T-cell activities, augmenting and inhibiting DTH respectively. Furthermore, cadmium suppressed the expression of already estab-lished DTH, in immune mice, even though DTH-effector T cells in the spleen of immune mice were not affected by cadmium injeciton. Such suppressive effects were demonstrated when cadmium was administered within 2 days before immunization or elicitation for DTH. Cadmium caused also within 2 days in mice thymic involution and splenomegaly.
    These results indicate that cadmium inhibits not only the generation of certain populations of T lymphocytes for DTH but also some mechanisms in the host involved in the expression of DTH.
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  • A SURVEY OF ROTAVIRUS INFECTION IN THE TROPICS
    SHOZO URASAWA, TOMOKO URASAWA, YUWONO DJOKO, KOJI FURUYA, SUMINORI AKI ...
    1981 Volume 34 Issue 5 Pages 293-298
    Published: 1981
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.34.293
    JOURNAL FREE ACCESS
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    The age distribution of rotavirus antibody in the serum of inhabitants of Laos and Indonesia was studied by the neutralization test using antigenically related calf rotavirus (NCDV) as a substitute for non-cultivable human rotavirus. The results revealed that both the rate of antibody-positives and the modal titers of antibody distribution by each age group in these countries were higher than those in respective age groups of Japanese, which suggest higher endemicity of rotavirus infection in these countries.
    A survey of rotavirus in diarrheic patients' stools by enzyme-linked immunosorbent assay indicated that the virus infection occurred most frequently among infants between 4 and 12 months of age.
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  • PURIFIED HUMAN PLASMA PROTEINS OF UNKNOWN FUNCTION
    HANS GERHARD, HEINZ HAUPT
    1981 Volume 34 Issue 5 Pages 299-327
    Published: 1981
    Released on J-STAGE: March 19, 2010
    DOIhttps://doi.org/10.7883/yoken1952.34.299
    JOURNAL FREE ACCESS
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    The development of new analytic and preparative techniques in the field of protein chemistry has essentially extended our knowledge about the variety of human plasma proteins in the last 15 years. In many cases plasma proteins have been particularly determined by immunologic techniques, partially highly purified and physicochemically well characterized, before knowing the biological function. To these proteins belong among others the α1-antitrypsin, Cl-inactivator, α2-macro-globulin, Gc-globulin and the cold-insoluble globulin. Today we know more than 100 proteins being isolated from human plasma and among these are nearly 20, of which the biological function is not yet known. To this group are belonging proteins, which are known since many years, like the α1-acid glycoprotein and the C-reactive protein as well as proteins, which have only been described in the last years and which partially have an interesting chemical structure, e.g. the histidinerich 3, 8S-α2-glycoprotein and the leucine-rich 3, 1S-α2-glycoprotein, of which every fifth amino acid is formed by leucine.
    It is to be hoped that the special chemical structure of some of these human plasma proteins as well as the quantitative immunologic determination in different patient sera will give hints to their biological function.
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