Jinko Zoki
Online ISSN : 1883-6097
Print ISSN : 0300-0818
ISSN-L : 0300-0818
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Volume 12, Issue 1
Displaying 51-100 of 106 articles from this issue
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  • Compliance of vascular materials
    T. SASAJIMA, Y. KUBO, M. INABA, Y. IZUMI, H. SAKAI, N. SAMEJIMA
    1983 Volume 12 Issue 1 Pages 179-182
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.179
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    We menufactured a simple device to estimate the statical compliance of normal dog arteries and various vascular materials. In consequence, BiograftR(compliance; C=0.107±0.007, mean±SD) is the most compliant vascular material, but dog arteries (thoracic aorta C=0.491±0.079, carotid artery C=0.356±1.01) were several times more compliant.
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  • [title in Japanese]
    [in Japanese]
    1983 Volume 12 Issue 1 Pages 183
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.183
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  • Evaluation of the 4cases of dissecting aneurysms which underwent surgical treatment with an int raluminal ringed graft
    T. OKOSHI, M. ENDO, A. HASHIMOTO, H. KOYANAGI
    1983 Volume 12 Issue 1 Pages 184-187
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.184
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    Intraluminal ringed graft were utilized for surgical treatment of the 4 cases of dissecting aneurysms; typeI, type IIId, typeI with aortic insufficiency grade 4, type IIIa. All were male, and the age range was 35 to 62 years with an average age of 52. Each operation was undergone from immediafely after the onset to four and a half months after the onset. Follow-up has been from 6 to 15 months with a mean of 10 months, and all patients are alive. Aortic cross-clamp time ranged from 50 to 122 minutes with a mean of 72 minutes. The case which underwent concomitant plasty of the left coronary orifice and aortic valve replacement required 122 minutes' aortic cross-clamping. The true lumen diameters were measured by means of angiogram, CT, UCG, but their values were all larger than the actually utilized graft diameters.
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  • Below-Knee bypass using Gore-Tex reinforced vascular grafts
    S. KOIDE, S. INAMURA, K. KANABUCHI, I. SZUKI, [in Japanese], [in Japan ...
    1983 Volume 12 Issue 1 Pages 188-190
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.188
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    We implanted the Gore-Tex reinforced grafts as below-knee bypass for four cases of ASO, and as a popliteal artery replacement for a case of poplitecl pseudo-aneurysm due to Beget's disease. All grafts are now well patent at the time of three to seven months after implantation.
    Post-operatire graft angio graphy on knee-flexion showed no fold on the graft, which is usually found on the non—ringed Gore-Tex graft on knee-flexion.
    This reinforced graft should be expected to be used as a “beyond-joint” bypass and a thovacic venous prosthesis.
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  • Prostacyclin and implanted Gare-Tex graft
    H. URAYAMA, C. YOSHIDA, D. TUJIGUCHI, Y. WATANABE, T. IWA
    1983 Volume 12 Issue 1 Pages 191-194
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.191
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    Φ5mm Gore-Tex graft was implanted to the femoral artery of mongrel dog and Prostacyclin (20ng/kg/m) was infused. The platelet aggregation by ADP 30μg was inhibited and the blood flow was increased.
    Prostacyclin decreased the adhesion of platelets and the thrombus formation of the graft, therefore prevented the early occlusion. Late graft failure by intimal hyperplasia is also prevented because Prostacyclin reduses the platelet factor that stimulates the smooth muscle cells to miglate and proliferate.
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  • A New Temporary Tube in Aortic Surgery
    An application of Heparinized Hydrophilic Polymer(H-PSD)
    Kazuhiko SHIMAZU, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1983 Volume 12 Issue 1 Pages 195-198
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.195
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    As previously reported, H-PSD polymer shows excellent antithrombogenecity due to the continuous release of heparin from its surface into blood stream for a longer period.
    In this study, an application of the H-PSD polymer to bypass tubes was investigated in the animal and clinical experiments. 3 cases (1 dissecting aneurysm, 2 coarctation of the aorta) was operated on using this bypass tubes. It was found that during and after the bypass the hematologic parameters remained in the normal levels and SEM studies showed no thrombus formation. This H-PSD polymer seems a promising material for the temporary bypass tubes in aortic surgery.
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  • Comparison of long term implantation of Modified Ureter Graft and Gore-tex graft in small caliber artey
    Y. MINEMURA, K. NAGAOKA, Y. NAKAGAWA, K. OKUI
    1983 Volume 12 Issue 1 Pages 199-202
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.199
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    For small caliber artery replacement, modified ureter graft was invented from pig ureter, treated with ethyl-ether and glutaraldehyde. 18 new grafts, 3-4mm in diameter, were implanted in the femoral arteries of 9 dogs. in contrast, 10 Gre-tex grafts of 4mm in diameter were inserted in the other 5 dogs. The new graft had a 56% patency rate at 1 year, whereas Gore-tex had 0%. 1 (5.6%) infected in the new grafts and 3 (30%) infected in Gore-tex graf ts. The new grafts had no decrease nor increase in graft diameter except 1. Histologically, the modified ureter graft had not much changes as calcification or cell infiltration. There was no difference between the 1 year patent graffs and 2 year patent grafts. 3 were obstructed from pannus hyperplasia and one of the patent graft showed pannus hyper plasia though not obstructed that this graft may need some immunosupplessants or antiplatelet agents for better results.
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  • [title in Japanese]
    [in Japanese]
    1983 Volume 12 Issue 1 Pages 203
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.203
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  • Clinical and experimental studies of velour Dacron prosthetic grafts
    K. YASUDA, H. HONMA, M. SAKUMA, T. GOHDA, Y. KASHIMURA, J. MATANO, H. ...
    1983 Volume 12 Issue 1 Pages 204-207
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.204
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    Arterial reconstructive surgeries were performed in 101 patients using double velour Dacron prosthetic grafts. Velour Dacron prosthetic grafts have given excellent results as large sized artery replacement and bypass. It appears to be an acceptable vascular substitute for surgical procedures in the aortoiliac resion. On experimental studies of systemic-pulmonary shunts using small caliber grafts (3mm diameter) in dogs, the patency rates of velour Dacron grafts were superior to those of PTFE grafts.
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  • Effectiveness of 4-6 tapered Gore tex graft to A-V fistula for chronic hemodialysis
    H. UJIIE, N. AKABA, Y. KAWAGUCHI, K. UMEZAWA, Y. ODA, T. MIYAHARA, K. ...
    1983 Volume 12 Issue 1 Pages 208-210
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.208
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    Various methods of shunt operation are available for gaining blood access in hemodialysis, among, which internal shunt is in most favorite use nowadays. We make it a practice to perform a side-to-side anastomosis of the radial artery and radial cutaneous vein somewhat proximal to the wrist on the opposite side of the whip arm as the procedure of first choice. Unfortunatery, however, there are cases in which the vein is too small to ensure sufficient blood flow to accomplish hemodislysis or in which, after the surgical creation of a shunt, the formation of a varix, or even occlusion, results from frequent puncture. In such an instance we have used a vascular prosthesis. The purpose of this paper is to descride our experience with newly developed 4-6 tapered Gore tex graft in the creation of A-V fistula. The procedure consists of anastmosing a prosthesis of 4mm diameter with the artery and another of 6mm diameter with the vein. The prostheses provided a satisfactory run off with an inproved patency rate and thus proved to be effective in the creation of A-V fistula under unfavorable conditions.
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  • Experimental study for small caliber arterial prostheses
    -A pilot study using braided tubes-
    Y. KOMOTO, T. KOHMOTO
    1983 Volume 12 Issue 1 Pages 211-214
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.211
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    Braided tubes were constructed evenly and processed by means of alkaline reduction method to produce porosity. 4mm I. D. and 12-18cm long grafts were implanted to bypass from left subclavian artery to coeliac trunk by end to end fashion in the chest cavity of dogs. Porosity of the stretched graft is minimal enough to prevent bleeding through meshes at the time of implantation and biological porosity will be produced as the graft shortening develops in a long time. 40% of patency was obtained in the group of 65%-reduction as well as in the control 5-7 months after implantation. Improved patency rate will be obtained by approximation of graft compliance to that of the host artery.
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  • Clinical use of vascular prosthesis pretreated with fibrin glue
    M. MATSUDA, T. BAN, J. SONEDA, K. HIRATA, K. NISHIMURA, M. HANADA
    1983 Volume 12 Issue 1 Pages 215-216
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.215
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    Ascending aorta replacement under extracorporeal circulation is often associated with uncontrollable bleeding through the prosthetic wall in spite of the preclotting with fresh blood. Instead of the preclotting with blood, vascular prostheses were pretreated with fibrin glue and clinically utilized. Fibrin glue consists of 2 components; highly concentrated fibrinogen as the substrate and thrombin, calcium and aprotinin as the thromboplastic substances. The high concentrated fibrinogen solution was firstly spreaded, then, the solution of thromboplastic agents was applied to the outer surface of prostheses. After a few minutes a thin fibrin film developed. The pressure tolerance test was performed and leakage through the pretreated prostheses was not seen under the pressure of 300mmHg.
    In three patients undergoing ascending aorta replacement under extracorporeal circulation the pretreated Dacron grafts were implanted and there was no blood loss across the prostheses. It is concluded that the fibrin glue is available for the vascular surgery.
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  • Studies of coating vascular prostheses with fibrin
    Y. IZUMI, Y. KUBO, T. SASAJIMA, M. INABA, Y. NISHIOKA, N. SAMEJIMA
    1983 Volume 12 Issue 1 Pages 217-220
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.217
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    In order to utilize the biological characteristics of fibrin for improving the blood compatibility and the tissue compatibility of vascular prostheses, the ideal conditions in fibrin conversion and the suitable method of coating the prostheses with fibrin were investigated. Fibrin net work suggested good blood compatibility.
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  • Late failure of preserved human umbilical vein graft
    T. SASAJIMA, Y. KUBO, Y. IZUMI, M. INABA, H. SAKAI, N. SAMEJIMA
    1983 Volume 12 Issue 1 Pages 221-224
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.221
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    Among seventy two arterial reconstruction using BiograftR 3 late failures developed from 30 months to 5 years postoperatively. Reoperation of all three showed severe pannus hyperplasia at the anastomotic sites. In microscopic examination of the Biograft specimens, the layers were compressed, but the basic architecture remained intact.
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  • Experimental Studies on APICO-AORTIC BYPASS using Valved Conduits Graft for Relief of Left Ventricular Outflow Tract Obstruction
    H. HARADA, T. KAZUI, [in Japanese], H. TAKEDA, T. SASAKI, M. KANEKO, S ...
    1983 Volume 12 Issue 1 Pages 225-228
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.225
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    The extraanatomic bypass procedures from the left ventricle to the descending thoracic aorta using the valved conduits graft were performed in the experimental animal with supravalvular and subvalvular aortic stenosis. The effect of Apico-Aortic Bypass procedure on the left ventricular fuction, coronary blood flow and oxygen consumption was compared between in the suprava lvular stenotic group and subvalvular stenotic group. These Procedures provided significant decrease of the left ventricular loading in the both supravalvular, and subvalvular stenotic groups. However, Apico-Aortic Bypass significantly increased the coronary blood flow in the subvalvular stenotic group, and on the contrary, decreased the coronary blood flow in the supravalvular stenotic group.
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  • [title in Japanese]
    [in Japanese]
    1983 Volume 12 Issue 1 Pages 229
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.229
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  • Analysis of problems of Total Replacement of Artificial Heart (TRAH)
    N. TAKIDO, I. FUJIMASA, K. IMACHI, A. MIYAMOTO, M. NAKAJIMA, K. MABUCH ...
    1983 Volume 12 Issue 1 Pages 230-233
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.230
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    Many unsolved problems thought to be remained in the operative and postoperative care and disturbed the good result of TRAH.
    By improving several items for TRAH operation and postoperative care and evaluating the effects of them with hemodynamic, blood gals and blood chemical data, those problems made to be clear. Shallow anethesia, hypothermic high-osmoral non-hemic priming CPB, unilateralthoracotomy autotransfusion of intrapulmonary vessel improved hemodynamic blood gas and blood chemical data and could get good survival results on TRAH experiment of goat.
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  • Experimental study of sutureless vascular prosthesis for total artificial heart replacement
    F. IWAYA, S. HOSHINO, M. HONDA, T. IGARI, H. INOUE, M. ANDO, K. TAKANO ...
    1983 Volume 12 Issue 1 Pages 234-236
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.234
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    Sutureless vascular prosthesis with quick connector was utilized for outflow side of total artificial heart surgery in order to saving time and decrease surgical bleeding. Four calves were operated with this method. Cardiopulmonary bypass time was shortened significantly and there was less postoperative bleeding compared with suture method. Immediate postoperative course was satisfactory in all calves and one survived 34 days which was the longest in our laboratory. There was no discouraging findings macroscopically and histopathologically in aorta and Pulmonary artery.
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  • Is it possible to control the animal with a total artificial heart by pump output alone
    M. NAKAJIMA, I. FUJIMASA, K. IMACHI, A. MIYAMOTO, N. TAKIDO, K. MABUCH ...
    1983 Volume 12 Issue 1 Pages 237-240
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.237
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    Elevation of CVP in a total artificial heart (TAH) goat was studied from the view point of venous conditions. Increase of venous tension was observed in a TAH goat in comparison with a normal control.
    Although other vital conditions were quite well, the result indicated the difficulty of controlling the venous tone in a TAH goat by pump output alone.
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  • Noninvasive flow measurement for artificial heart using a doppler method
    S. NITTA, M. TANAKA, K. NITTA, H. TAKEDA, M. MARUYAMA, H. OHKAWAI, A. ...
    1983 Volume 12 Issue 1 Pages 241-244
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.241
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    The use of flow visualization techniques to obtain information on fluid behavior in the post valvular resion and continuous wave-form doppler flowmetery were performed simultaneously to analyze the reliability as a non-blood-contact flow measurement.
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  • A newly designed cannula entrance in pulsatile pump—with special concideration about venous wall collapse
    S. HASHIMOTO, T. ITO, H. MORIYA, H. YANAGISAWA, A. ISHIHARA, M. MORITA ...
    1983 Volume 12 Issue 1 Pages 245-248
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.245
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    When the blood is drawn from the cardiovascular tract into pulsatile pump, sufficient flow rate cannot often be attained, because the collapsible venous wall clings to the cannula entrance and the contraction of the flow path occurs. To avoid this contraction, we have designed a new cannula entrance which has the cage (made of stainless steel wire) with larger amount of area of side apertures. Using this newly designed cannula as the inlet of the piston-bellows type of artificial heart for dogs, we were able to attain sufficient flow rate (perfusion index: 2.2l·min-1·m-2) repeatedly.
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  • [title in Japanese]
    [in Japanese]
    1983 Volume 12 Issue 1 Pages 249
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.249
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  • Non-pulsatile circulation with a centrifugal pump as an artificial heart on the awake goats
    A. MIYAMOTO, I. FUJIMASA, K. IMACHI, N. TAKIDO, M. NAKAJIMA, K. MABUCH ...
    1983 Volume 12 Issue 1 Pages 250-253
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.250
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    The difference between pulsatile and non-pulsatile circulation on the three awake goats, whose hearts were substituted by the artificial heart, was studied. The goats had two sac pumps (SAC P.) initially and the only left sac pump was switched to a centrifugal pump (C. F. P.) 1-2 weeks later. If the non-pulsatile circulation could not be continued the centrifugal pump was replaced with a sac pump again. One goat survived for 51 hours, increasing right pump flow by 20mL/Kg/min to 110mL/Kg/min in non-pusatile circulation. The renal function was within normal limit but total systemic resistance was increasing during non-pulsatile circulation.
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  • NONPULSATILE BIVENTRICULAR BYPASS DURING CHRONIC VENTRICULAR FIBRILLATION
    S. TAKATANI, L. GOLDING, H. HARASAKI, I. YADA, S. KOIKE, R. YOZU, L. F ...
    1983 Volume 12 Issue 1 Pages 254-257
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.254
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    Nonpulsatile biventricular bypass during chronic ventricular fibrillation. Chronic nonpulsatile blood flow was established in 4 animals, ranging from 34 to 93 days. Two centrifugal type nonpulsatile pumps were used to bypass both ventricles which were kept fibrillated during the entire course of experiments. After acute responses during the first 7 to 10 days postoperatively, hemodynamics returned to normal and afterwards all organ function was maintained within normal ranges, provided adequate flow and pressure were maintained. Therefore, nonpulsatile blood flow is not a limitation for animal's survival.
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  • Left ventricular bypass (LVB) and biventricular bypass (BVB) were performed on canine heart using centrifugal blood pumps
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1983 Volume 12 Issue 1 Pages 258-261
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.258
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    During LVB, left ventricular support was sufficient from the viewpoint of bypass flow, decrease in myocardial oxygen consumption, TTI reduction and decrease in LV max. dp/dt. When LVB was applied on failing heart, increase in cardiac output was observed. BVB was effective in terms of the left and right ventricular decompression. BVB was also effective on failing heart in terms of decompressing the right ventricle. During ventricular fibrillation, bypass flows were not sufficient to maintain systemic, pulmonary and coronary circulation.
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  • IABP MONITOR MODEL-2 for Monitoring the Performance of an Intra-Aortic Balloon during IABP
    Y. TERASHIMA, J. AKUNE, S. HIROSE, Y. OGAWA, A. SEKI, M. MIYAZAKI, I. ...
    1983 Volume 12 Issue 1 Pages 262-265
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.262
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    The performance of an intra-aortic balloon during IABP was successfully monitored by the newly designed device, “IABP MONITOR MODEL-2”, which computed and displayed the change in the actual volume of the balloon, with input of the change in aortic pressure and transthoracic electrical impedance, etc. Additionally, compliance of the aorta was obtainable using this device.
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  • Effects of the V-A bypass combined with IABP in endotoxin induced shocked dogs
    Minoru NOUSO, [in Japanese], [in Japanese], [in Japanese], [in Japanes ...
    1983 Volume 12 Issue 1 Pages 266-269
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.266
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    The most adequate way of the mechanical assist for cardioplumonary failure was studied in endotoxin induced shocked dogs by V-A bypass with oxygenator combined with or without IABP. Hemodynamicaly, IABP was as useful as V-A bypass. But V-A bypass, perfused from carotid artery, with IABP was the most effective. As far as blood gas analysis was concerned, IABP alone was no effect in comparison to V-A bypass. V-A bypass, perfused from carotid artery, combined with IABP had the strongest effectiveness to assist for cardiopulmonary failure. 1. acute cardioplumonary failure 2. V-A bypass 3. IABP 4. endotoxin induced shock 5. Aortic-, femoral perfusion
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  • [title in Japanese]
    [in Japanese]
    1983 Volume 12 Issue 1 Pages 270
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.270
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  • Adsorbents for selective removal of immunoglobulin
    H. KASAI, T. AGISHI, [in Japanese], [in Japanese], [in Japanese], [in ...
    1983 Volume 12 Issue 1 Pages 271-274
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.271
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    Porous glass beads have been evidenced to show specific adsorbability to gamma globulin in spite of very weak adsorbability to albumin in aextracorporeal circulation system. The adsorbability of 150g of the glass beads to 2000ml of the separated plasma was known to be saturated approximately 60 minutes after a start of the perfusion, but regain after being rinsed with physiological saline. An apparatus in which two glass beads adsorbent columns are alternately perfused with blood and rinsed with saline in order to un interruptedly conduct the adsorption has been produced and investigated for the performance. The experimental results show that the columns satisfactority maintain the adsorption and can be unitized in clinical practice in terms of the adsorbability.
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  • ADSORPTION AND REMOVAL OF ENDOTOXIN BY POLYMYXIN-SEPHAROSE, ITS PROPERTIES AND APPLICATIONS
    M. UMEDA, M. ASAKAWA, T. TERADA, Y. TATSUMI, N. KASHIWARA, J. KAWAKITA ...
    1983 Volume 12 Issue 1 Pages 275-278
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.275
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    How polymyxin-B binds to and inactivates endotoxin was studied. Antibacterial property of 30μg of PX was inactivated by 500μg of ET (extracted from S. min R. 595), while the biological activity of 4μg of ET was inactivated completely by 40μg of PX. Then, PX was immobilized on CNBr activated Sepharose by covalent bond. (PX-Seph). 680μg of stabilized PX could remove 40μg of ET by adsorption. Such effect was found also in plasma. Affinity constant (Ka) in this binding showed a high value of 4.06 x 108.
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  • Development of Handytype Plasms Exchange System Plasma Pheresis has been applied to many kinds of immunological diseases
    H. KAWAGUCHI, T. UCHIMA, T. WATANABE, K. FUKUI, O. OTSUBO
    1983 Volume 12 Issue 1 Pages 279-282
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.279
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    We developed the new system with our idea that is to controll the inlet pressures of double tube pump to drain and return blood by automatic pressure controller, improving our “Handy type Plasma Exchange Hemofiltration System in 1979”. It is 250mm Width, 350mm Hight, 366mm Depth and about 15Kg Weight. It contains new type of blood pump, heparin infuser, T. M. P. and Venous pressure monitors with upper and lower limit alarms, bubble detector. Results of in vitro and in vivo examinations are satisfied with safty use and various applications. Deviation between substitution and filtrate volume is -2.93% averaged 3 times in vivo examinations (filtrate: 2000ml).
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  • Experience of Plasmapheresis in SLE
    O. NISHI, T. NAKANO, S. HIRANO, T. HASHIMOTO, H. MATSUURA, T. MATSUMOT ...
    1983 Volume 12 Issue 1 Pages 283-285
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.283
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    We tried plasmapheresis on different cases of SLE. Case 1 was a CIC positive case with an acute lupus nephritis. Plasmapheresis combined with hemodialysis caused the urinary output to increase again and the serum creatinine coefficient to drop. And attempt was made to drop hemodialysis. Case 2 had an acute case of renal failure. But it was CIC negative. No improvement was observed with regard to urinary output and serum creatinine coefficient. Case 3 showed Raynaud's phenomenon and marked skin abnormalities. This case was CIC positive. With plasmapheresis, CIC turned negative and skin abnormalities disappeared. These results indicated that, as reported in a number of studies, plasmapheresis is effective for CIC positive cases in SLE. And the combination therapy with steroid is necessary.
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  • [title in Japanese]
    [in Japanese]
    1983 Volume 12 Issue 1 Pages 286
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.286
    JOURNAL FREE ACCESS
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  • Clinical effects of continuous cryofiltration(CCF) on rheumatoid arthritis
    N. AZUMA, T. NOBUTO, M. SUZUKI, S. SHINAGAWA, T. MATSUGANE, K. SHIMO, ...
    1983 Volume 12 Issue 1 Pages 287-292
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.287
    JOURNAL FREE ACCESS
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    Continuous cryofiltration (CCF) was performed a total of 821 sessions on 26 rheumatoid arthritis patients. The clinical effectiveness of CCF was defined according to the criteria described by Wallece et al. By these criteria, patients were evaluated as follows: Excellent 9 patients (34.6%), Good 4 patients (15.7%), Fair 7 patients (30.0%), Poor 5 patients (19.2%), Undefined 1 patients (3.8%). 20 out of 26 patients showed clinical improvement. A study of clinical response in relation to the number of treatment of CCF performed showed that favorable responses tended to be observed more than 25 sessions. In the examination of immunological data, no significant differences were observed in the course of CCF treatmentt for all patients. In cases of A-V fistula occlusion, the superficialization of brachial artery is recomended for blood access. We have not a fatal complication in the 821 sessions of CCF therapy. CCF is a safe, inexpensive and effective for the treatment of the rheumatoid arthritis therapy.
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  • Plasma exchange in collagen disease
    H. AMEMIYA, H. SATO
    1983 Volume 12 Issue 1 Pages 293-296
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.293
    JOURNAL FREE ACCESS
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    Plasma exchange (PEx) was performed in 20 patients with collagen disease. In SLE, various symptoms were improved immediately following PEx except for nephrotic syndrome secondary to lupus nephritis. As circulating immune complexes (IC) were frequently detected in patients with clinical effect, it seems to be that the positive IC is one of the indication for PEx. In PSS and MCTD, severe Raynaud's symptom was improved but there was no change on the other clinical features. As to PEx for Raynaud's symptom, plasma viscosity may be useful parameter of this procedure. When the results of PEx with double filtration plasmapheresis and centrifugaton method were compared, the advantage of the former was able to reduce the amount of albumin for substitution significantly.
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  • Indication and limitation of plasmapheresis for hyperbilirubinemia
    Y. OHTAKE, M. ODAKA, H. HIRASAWA, H. KOBAYASHI, S. ODA, S. KOBAYASHI, ...
    1983 Volume 12 Issue 1 Pages 297-300
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.297
    JOURNAL FREE ACCESS
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    The plasmapheresis with plasma exchange was performed for 71 times upon 24 patients using Haemonetics model 30. Thirteen of them suffered from postoperative hyperbilirubinemia and were included in the study. The plasmapheresis was applied upon these hyperbilirubinemic patients in order to reduce serum bilirubin level. The plasmapheresis seemed to be effective for hyperbilirubinemia following hepatectomy but not to be effective for hyperbilirubinemia among multiple organ failure patients. Therefore the indication of the plasmapheresis should be considered cautiously since it needs huge amounts of fresh frozen plasma.
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  • Effects of plasma exchange on the treatment of cancer patients
    H. KONO, K. YAJIMA, K. NAKANISHI, T. TOGE, T. HATTORI
    1983 Volume 12 Issue 1 Pages 301-304
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.301
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    It is now gradually accepted that the sera of cancer patients contain the immune inhibitory factors which suppress a number of lymphocyte functions in vitro, increasing with the progress of the disease, Plasma exchange seems to be useful and adequate procedures to dilute or eliminate these inhibitory factors. In this paper, plasma exchange was combined with immunochemotherapy of the patients with advanced cancer and its effect was discussed. Nine patients underwent plasma excharge. Five of them had an partial response documented one or two weeks after the first plasma exchange, and various immunological parameters were remarkably improved. Combined treatment of plasma exchange and immunechemotherapy might be beneficial on cancer patients.
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  • The technical consideration of cryofiltration
    S. SHINAGAWA, N. AZUMA, M. SUZUKI, [in Japanese], T. NOBUTO, [in Japan ...
    1983 Volume 12 Issue 1 Pages 305-310
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.305
    JOURNAL FREE ACCESS
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    In the cryofiltration the macromolecule filters having the pore size 0.2 need the cooling at 4°C. It is able to treat with cryofiltration using macromolecule filter at 15-25°C which have the pore size between 0.1 and 0.08. But the removal ratio has been influenced by the filtrate temperature. It is good for macromolecule filter having pore size 0.2 to treat with below 4°C in the two way method, also it is the best for macromolecule filter having 0.1-0.08 to treat with between 15-25°C in recirculation method.
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  • Plasma perfusion system for immunoadsorption of immune complex
    Z. YAMAZAKI, Y. FUJIMORI, T. TAKAHAMA, T. WADW, T. MIYAMOTO, M. KAZAMA ...
    1983 Volume 12 Issue 1 Pages 311-314
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.311
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    A new immunoadsorbent (I-02), adsorbing rheumatoid factor and immune complex, has been developed. Batchwise adsorption studies revealed that I-02 is more efficient than Protein A- Sepharose CL4B. During ex vivo I-02 plasma perfusion in the dogs, coagulation and fibrinolysis factors were almost constant. Blood biochemical parameters were within normal limits. Platelets aggregation value is almost constant. I-02 plasma perfusion was carried out in the patient with chronic rheumatic arthritis with satisfactory results.
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  • Studies of selective removal and immunosuppression in plasmapheresis Plasmapheresis therapy recently has become clinically available
    Y. HAYASAKA, J. MINAGUCHI, S. SAITOH, H. ARAI, T. SANAKA, K. TAKAHASHI ...
    1983 Volume 12 Issue 1 Pages 315-318
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.315
    JOURNAL FREE ACCESS
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    The purpose of plasmapheresis is to remove antigens, antibodies, immune complexes, complement and coagulation factors in the treatment of renal transplant rejection. However, unnecessary removal of immune regulatory factors may simultaneously occur and stimulate immune reaction to result in rebound after plasmapheresis.
    Suppressor and growth soluble factors (kinds of lymphokins), well known as regulators in immune responses. In vitro study demonstrates adsorbability of 65 materials to suppressor and growth soluble factors. Of these, Amberlite XAD-2 shows large capacity of adsorbability to growth soluble factors, but not plasma proteins. Adsorbability of Amberlite XAD-2 to growth soluble factors which is contained in suppressor soluble factors is confirmed by the experimental result that suppressive effect is sharply incresased from 19.2 to 59.0% after 10 minutes incubation and to 73.0% after 30 minutes incubation. Irradiation to lymphocytes by Ultraviolet (UV) ray has strong capacity of immune suppression, and we studied suppressive effect of UV with irradiation time, wave length and its intensity.
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  • [title in Japanese]
    [in Japanese], [in Japanese]
    1983 Volume 12 Issue 1 Pages 319
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.319
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  • Blood compatibility of sputter deposited metals
    T. YUTA, Y. MITAMURA
    1983 Volume 12 Issue 1 Pages 320-322
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.320
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    Relation between blood compatibility of sputter deposited metals and their surface charge, wettability and roughness was investigated. Materials tested were: (1) titanium (Ti), nickel, copper and aluminum and (2) composite metal of Ti and the above metal. Blood compatibility of the materials was evaluated by the in vitro “kinetic test”. Findings were: (1) Blood compatibility of the metal, which is low in the electromotive series was better than that higher in the series. (2) Antithrombogenecity of the composite metal was better than that of Ti. (3) No good relation between blood compatibility and wettability or surface roughness was obtained.
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  • Effect of thickness of coated polymers on biocompatibility
    Y. IMAI, A. WATANABE
    1983 Volume 12 Issue 1 Pages 323-326
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.323
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    Glass coverslips and plastic sheets for tissue culture were coated with dilutions of the solution of three different polymers. These films varied between 4 and 6000nm in thickness. The coated specimens were measured for contact angle, and cultured cells and platelets were incubated on the specimens for observation of their morphological change. Coating thickness of more than 400nm was necessary for the coated polymer to be independent of the base substrates.
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  • Platelet adhesion to collagen/mucopolysaccharide hybrid matrix
    S. KASAI, T. AKAIKE, T. KUNIMOTO, K. NITTA, T. MIYATA
    1983 Volume 12 Issue 1 Pages 327-330
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.327
    JOURNAL FREE ACCESS
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    Collagen is a major component of the extracellular matrix in living tissues and can influence the adhesion, morphology and migration of cells and in some cases, differentiation. On the other hand, since mucopolysaccharides (glycosaminoglycans) possess multiple anionic charges and have strong affinity for water, the resulting water layer may inhibit adhesion of platelets to the surfaces. For this reason, a hybrid matrix consisting of collagen and mucopolysaccharide may be a blood- and tissue-compatible material. Our results indicate that collagen/hyaluronic acid matrix markedly inhibits platelet adhesion, furthermore, the proliferation of fibroblasts on collagen/hyaluronic acid matrix as well as on collagen matrix is well.
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  • Biomaterials which can induce naturally the ability of the living body
    Y. NOISHIKI
    1983 Volume 12 Issue 1 Pages 331-333
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.331
    JOURNAL FREE ACCESS
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    To develop a new biomedical polymer, it was suggested that the most important point was how naturally to induce a function and ability of the living body by the polymer. The living body has a nature of adaptability and restoration ability. Many of the artificial organs have been accepted to the living body by the nature. For example, against several types of vascular prostheses and grafts, the living body accepted them, however, the living body had made efforts to accept themin its own way.
    So that. if the living body falls into a poor condition, the limit of the adaptability of it becomes narrow, and the artificial organs resulted to be functional disordered So we have develop a new materials which do not forced the living body to accept it.
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  • Clinical Application of urokinase-treated drain for anithrombogenic material
    T. OHSHIRO, Y. KIDO, Y. OGAWA, K. OKAGAWA, G. KOSAKI, K. TAKAGI
    1983 Volume 12 Issue 1 Pages 334-337
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.334
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    We have already experienced the many complications such as sepsis, abscess, infection etc, when the postoperative hemorrhagic effusion failed to be eliminated from thoracic or abdominal cavity through the drainage tube. the main cause of its failure is based on the occlusion of drainage tube, due to the thrombus formation. This report presented the possibility of clinical application of new polyvinyl chloride drain, on which urokinase was immobilized via Gantrez. The urokinase-treated drain had the high anithrombogenicity and followed the superior clinical results.
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  • Species difference in tissue response to polymeric materials
    Y. IMAI
    1983 Volume 12 Issue 1 Pages 338-341
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.338
    JOURNAL FREE ACCESS
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    Poly (2-hydroxyethyl methacrylate), polyurethane, (polystyrene)-(ethylene/butene-1) block copolymer, and polysulfone were implanted subcutaneously in rats, hamsters, and guinea pigs. The tissue response and tumorigenesis caused by the polymers were compared among the three species of the animals. Thick fibrous capsule formation and high tumor production were noted only in rats, while no tumorigenesis and thin fibrous capsule formation were observed in hamsters and guinea pigs.
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  • [title in Japanese]
    [in Japanese], [in Japanese]
    1983 Volume 12 Issue 1 Pages 342
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.342
    JOURNAL FREE ACCESS
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  • A microcomputer controlled mixed gas supply for ECMO
    E. TAKAHASHI, S. SHIMIZU, K. YAMAMOTO, T. MIKAMI
    1983 Volume 12 Issue 1 Pages 343-346
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.343
    JOURNAL FREE ACCESS
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    In ECMO, it will be indispensable to control the gas exchanging rate in artificial lung automatically to keep the outlet blood gas at appropriate level independent of the inlet condition. However, a simple feedback control is not applicable for this purpose because it tends to lead the system unstable. To realize the stable control with good transient characteristics, the new control method where a feedback controller is combined with a feedforward controller was designed. The computer simulation and animal experiment revealed the feasibility of this newly developed control method. A device which supplies the desired Po2 and Pco2 in the gas was useful in this study.
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  • Cardiopulmonary Restriction Caused By Partial Veno-arterial Extracorporeal Lung Support In Dogs
    Shinkichi W., Sumio N., Kazuhiro O., Mikito I., Tatsuo T., Tetsuichi A ...
    1983 Volume 12 Issue 1 Pages 347-353
    Published: February 15, 1983
    Released on J-STAGE: October 07, 2011
    DOIhttps://doi.org/10.11392/jsao1972.12.347
    JOURNAL FREE ACCESS
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    Changes in cardiopulmonary functions were studied in 14 dogs underwent partial venoarterial extracorporeal lung support (30% of C. O.) for 3 (group I), 6 (group II). and over 28 hours (group III). Under air breathing, blood gases, A_aDo2, and Qs/Qt did not change after the experiments, whereas pure oxygen breathing revealed increase in A_aDo2 in group l and III, In group I postoperative DLCO decreased for a week and then recovered. Time course of static lung compliance was also likely. PPA, C. O. and TPVR did not change in all groups. We conclude that partial perfusion does not cause severe restriction of cardiopulmonary function but a little lasting for a week.
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