北関東医学
Online ISSN : 1883-6135
Print ISSN : 0023-1908
ISSN-L : 0023-1908
10 巻, 4 号
選択された号の論文の9件中1~9を表示しています
  • 第1編 まぶしによる気管支喘息の研究
    中沢 精二
    1960 年 10 巻 4 号 p. 497-512
    発行日: 1960/07/01
    公開日: 2009/10/21
    ジャーナル フリー
    1. Induction of asthmatic paroxysm was successfully performed on an inpatient with asthma due to Mabushi (straw on which silk worms are raised) usiug Mabushi or its extract solution.
    2. Artifical induction was attempted on this patient by inhalation of various food powders, but without any success.
    3. The patient was positive in skin, ocular, rhinic, pharyngeal test and Prausnitz-Küstner reaction with protein fraction of Mabvshi. Further, the inductiou succeeded on this patient with this protein fraction.
    4. Inhalation test and analysis of the antigen by skin and other allergic reactions disclosed that the antigen was present in the protein fraction of Mabushi.
    5. The serum of this patient was negative in precipitation against this protein fraction.
    6. Desensitization with this fraction was confirmed by inhalation, and skin and other allergic reactions.
  • 第2編 こんにやく喘息の抗原に関する研究
    中沢 精二
    1960 年 10 巻 4 号 p. 513-521
    発行日: 1960/07/01
    公開日: 2009/10/21
    ジャーナル フリー
    The author sought antigen of konjac asthma-allergic and inhalating asthma-which is rare in Japan.
    1. Inhalation, skin and precipitation test, performed on coniac asthma patients, revealed that the responsible antigen was present also in ammonium sulfate fraction of the flying conjac powder.
    2.This ammonium sulfate fraction could further be separated into two fractions by Tiselius method, filter paper and zone electrophoresis.
    3.According to the analysis by the latter two, it is highly probable that protein fraction of the antigen may be bound to a polysaccharide fraction.
    4.Induction experiments were carried out on two conjac asthma patients using the two fractions separated by zone electrephoresis, and the antigenicity was demonstrated in an fraction which was found further away from the origin.
  • 高草木 泰平
    1960 年 10 巻 4 号 p. 522-531
    発行日: 1960/07/01
    公開日: 2009/10/21
    ジャーナル フリー
    1) 長期保存ACD血液から, 温和な条件で溶血させて得られた赤血球残影は 0.005M~0.05MのATPによりPH8.0ですげ笠様に変形を示し, EDTAでもとの形にもどる.
    このような観察に適する残影の調製方法及び変形の種々の条件について検討し, 次の知見をえた..ADPはATPと同様な変形を惹起し, 無機正リン酸は似た変形をおこすが, AMP, 無機ピロリン酸は変形をおこさない.SH阻害剤は変形を阻止するが弗化ソーダ, Ouabain は阻害しない.PHは8.0附近がもっとも明瞭でKa+, K+, Li+は殆んど差がない.Mg++はあまり影響がない.
    2) ヘマトクリツトと同様な方法を検討して容積の変化と滲透圧及びATPによる変形現象との関連を追求した.高滲透圧中では残影の容積は減少するが, この現象と変形現象は強さの点, EDTAの作用, 阻害剤の作用等幾つかの点で異る事を明らかにした.
    3) 赤血球残影のATPaseをしらべて時間経過PH活性度曲線, Ca++, Mg++の影響, EDTA, dinitrophenolその他阻害剤の影響を観察した.赤血球球残影のATPaseは少くともその大部分はactomyosin型のATP説ではないと思われるが, サルコソーム及び肝ミトコンドリヤのATPaeとも異る.また弗化ソーダ, Mg++の影響その他幾つかの点から, ATPade活性の大部分はATPによる変形現象と関連がないと云う事を明らかにして, ATPによる変形現象が別種の蛋白と関係がある可能性について論じた.
  • 戸部 伊助
    1960 年 10 巻 4 号 p. 532-540
    発行日: 1960/07/01
    公開日: 2009/10/21
    ジャーナル フリー
    When a burn, covering 20 per cent of the body surface, was produced in male rats of Wistar strain after the ligation of the pylorus, ulcer developed in the glandular part of the stomach at the rate of 90 per cent, gastric juice secretion diminished below that in controls the amount of the juice and hydrochloric acid and total amount of pepsin decreased, and adrenal weight increased.
    When a burn was produced after giving electric damage to the hypothalamus, different effects were elicited according to the site of the damage. In the case of the lesion in the posterior hypothalamus, the development of ulcer rather increased. and the amount of the juice and hydrochloric acid and the total amount of pepsin remarkably diminished with significant decrease of adrenal weight. When, however, the lesion was in the medial or anterior hypothalamus, it was observed that the juice secretion, the total amount of pepsin and adrenal weight were significantly higher than in the cases of posterior lesion, showing no remarkable changes in the ulcer development.
    There was intimate correlation between changes in adrenal weight and the total amount of pepsin, which are both considered to be attributed to the action of ACTH released by the stress of the burn. And the part most closely connected with this release was found to be the posterior hypothalamus. The release of ACTH seemed to have no direct bearing on the development of gastric ulcer after the formation of burn in the rat.
  • 佐藤 普
    1960 年 10 巻 4 号 p. 541-553
    発行日: 1960/07/01
    公開日: 2009/10/21
    ジャーナル フリー
    Effects of anticholinergic drugs on gastric secretin induced by cinchophen were investigated on dogs with total gastric pouch, and it was found out that Antrenyl, Pro-banthine and Tropin all strongly inhibited such secretion, but that a little larger doses than that of insulin were necessary ; effect of Banthine was rather inferior to the above. These anticholinergic drugs were not considered to exert any inhibitory action on the hypothalamic-pituitary-adrenocortical system, which is related to the gastric secretion by cinchophen, but to inhibit the release of the secretory substance into the stomach by acting on its glandular cells. Regitin and chlorpromazine did not show any inhibitory acticn on gastric secretion by cinchophen.
    Combined administrarion of cinchophen and Tropin for 3 weeks produced ulcer as in controls.
  • 田中 明
    1960 年 10 巻 4 号 p. 554-564
    発行日: 1960/07/01
    公開日: 2009/10/21
    ジャーナル フリー
    Investigations for α-haemolysin, necrotoxin and leucocidin were carried out with 287 strains of coagulase-positive staphylococci, isolated from purulent foci and rhino-pharynx in this clinic in the period from April 1957 to May 1959. As the result, a relationship was found between the potency of the three kinds of toxins and phage types. Namely, many of group I strains especially type 80/847B, and almost all group II strains had toxins with high potency, while many of group III ones had toxins of low potencncy. Further, in nontypable strains, there were far more of low potency than in typable strains. A great many of strains from hospital infectioms belonged to type 80/847B and a small number bolonged to group III. However, a considerable number of type 80/847B and group III strains were isolated from the nose and pharynx of hospital inhabitants. This suggests that type 80/847B strains have strong infecting power, and group III weak one. Since the former in major cases possess high potent toxins and the latter low potent ones, some relation is considered to be present between these toxins and infecting power.
  • 二宮 俊作
    1960 年 10 巻 4 号 p. 594-614
    発行日: 1960/07/01
    公開日: 2009/10/21
    ジャーナル フリー
    Fifty four newborns, 659 female and 774 male sucklings with mormal hip joints, and 220 female and 40 male sucklings with congenital hip dislocation were investigated for the skincrease on the medial side of the thigh, with the following results :
    1) This crease is produced in the foetus by adducting force, exerted on the flexion of the hip and knee joint, and disappears in about 2 years after birth. This is dfferent from other skin-creases in this respect, and therefore can adequately be named “forced skincrease”.
    2) The skin-crease which is found under inguinal groove nearly in parallel with it disappears relatively early.
    3) Symmetry or asymmetry of these creases respectively found on the two thighs can not have any diagnostic significance.
    4) When the skin-creases respsctively found on the both thighs are asymmetry under the inguinal grooves, or when they are asymmetry, being respectively found a little higher and lower than the middle parts of the thighs, or when they are asymmetry, two being found slightly above and below the middle part of one thigh, and one on the middle part of the other thigh, there is strong suspicion of dislocation.
  • 第1篇 絨毛性性腺刺戟ホルモンの家兎排卵誘発作用に及ぼすステロイドホルモンの影響
    栗崎 和雄
    1960 年 10 巻 4 号 p. 615-625
    発行日: 1960/07/01
    公開日: 2009/10/21
    ジャーナル フリー
    絨毛性gonadotropinによる家兎排卵誘発現象はFriedman反応として広く妊娠診断に応用されているが, 使用家兎の体重や諸種内分泌環境の状態によつて, 卵巣の感受性に差のあることが認められている.例えば幼若家兎は成熟家兎に比べ感受性が悪く (Friedman, 黒津), 黄体の存在する家兎は感受性が悪く (藤間), 産褥家兎は感受性がよくなる (Dury &Bradburg, 小林) 等である.更に最近甲状腺や副腎の剔出によつてそれが変ること (比嘉) や黄体が存在していてもestrogen前処置すれば感受性がよくなること (小林 (拓)) なども報告されている.
    これらの問題はFriedman反応を実施する場合, 殊に精密な定量的検査を行なう場合などにはよく考慮せねばならない重要な問題であるが, しかしこれに関し従来充分な検討は行なわれていない.そこでこの点を明かにするために以下の種々実験を行ない, 家兎内分泌環境を種種変化させると絨毛性gonadotropinに対する卵巣の感受性が如何に変化するかを検索した.
  • 1960 年 10 巻 4 号 p. 626-645
    発行日: 1960/07/01
    公開日: 2009/10/21
    ジャーナル フリー
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