Replicated daughter chromosomes in
Escherichia coli move nonprogressively and abruptly from midcell toward the quarter positions at the early D (division) period. The chromosome positioning is controlled by the
mukA and
mukB gene products. The
mukA (tolC) gene encodes an outer membrane protein. Sequencing results of the mukB gene suggest that the
MukB protein (177kDa) has 5 distinct secondary structural domains, and two
MukB protein molecules from ca homodimer in coiled-coil regions, like myosin and kinesin of eukaryotic cells. MukB may provide the force required for the chromosome positioning and the amino terminal globular domain cntaining an ATP binding sequence may act as a "motor" domain.
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