生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
42 巻 , 6 号
通巻244号
選択された号の論文の13件中1~13を表示しています
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  • 下野 和実, 加茂 直樹
    原稿種別: 研究論文
    専門分野: 情報学
    2002 年 42 巻 6 号 p. 290-294
    発行日: 2002年
    公開日: 2002/11/23
    ジャーナル フリー
    Many organisms including human beings have rhodopsin as photoreceptor. In cell membranes of archaeal Halobacterium salinarum, there exist four rhodopsin-like proteins (so-called archaeal rhodopsins). Two of these work as light-driven ion pumps. The other two work as photosensors and are named sensory rhodopsin (sR) and phoborhodopsin (pR). pR mediates the negative phototaxis. Recently, X-ray crystallographic structure of pR derived from Natronobacterium pharaonis is reported, and allows us to investigate the function-structure relationship at atomic level. In this review, we describe our results on the photochemistry and the signal transduction mechanism of pR.
  • 松本 美佐子
    原稿種別: 研究論文
    専門分野: 情報学
    2002 年 42 巻 6 号 p. 295-300
    発行日: 2002年
    公開日: 2002/11/23
    ジャーナル フリー
    Toll-like receptors (TLRs) are pattern-recognition receptors that play key roles in detecting microbes and initiating inflammatory responses. Ten members of the TLR family have been identified in humans. TLRs consist of an extracellular domain containing leucine-rich repeats and a C-terminal flanking region, and a cytoplasmic signaling domain, called the Toll/IL-1 receptor homology domain. Each TLR recognizes a distinct ligand (s) and induces different, sometimes overlapping, immune responses. Here, I show that TLR2 recognizes bacterial lipoproteins, while TLR3 recognizes virus-derived double-stranded RNA and triggers downstream signals leading to interferon production.
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