巻号一覧
42 巻, 6 号
通巻244号
選択された号の論文の13件中1～13を表示しています
- |<
- <
- 1
- >
- >|
巻頭言
-
新村 信雄原稿種別: 研究論文
専門分野: 情報学
2002 年 42 巻 6 号 p. 261
発行日: 2002年
公開日: 2002/11/23
ジャーナル フリー
特集
-
山岸 明彦原稿種別: 研究論文
専門分野: 情報学
2002 年 42 巻 6 号 p. 265
発行日: 2002年
公開日: 2002/11/23
ジャーナル フリー -
内山 郁夫原稿種別: 研究論文
専門分野: 情報学
2002 年 42 巻 6 号 p. 266-269
発行日: 2002年
公開日: 2002/11/23
ジャーナル フリーMBGD is a database system for making use of rapidly accumulating microbial genome sequences through comparative analysis. The basic function of MBGD is to create an orthologous gene classification table, which comprises sets of "equivalent" genes among multiple genomes. In MBGD, classification tables can be created on demand with specified set of organisms and parameters. This feature becomes important to understand diversity of genomes using almost a hundred genome sequences now available.
抄録全体を表示PDF形式でダウンロード (327K) -
矢田 哲士原稿種別: 研究論文
専門分野: 情報学
2002 年 42 巻 6 号 p. 270-272
発行日: 2002年
公開日: 2002/11/23
ジャーナル フリーDIGIT is a computer program which finds genes by combining plural existing gene-finders. The comprehensive benchmark tests clearly showed that DIGIT whose model parameters were optimized for combining human ab initio gene-finders successfully discarded many false-positive exons predicted by the gene-finders and yielded remarkable improvements in prediction accuracy compared with existing ab initio gene-finder. In this paper, I introduce the use of DIGIT via internet as well as the outline of DIGIT algorithm.
抄録全体を表示PDF形式でダウンロード (259K) -
皿井 明倫, 安 虹江, 北島 浩司原稿種別: 研究論文
専門分野: 情報学
2002 年 42 巻 6 号 p. 273-275
発行日: 2002年
公開日: 2002/11/23
ジャーナル フリー3DinSight is an integrated database and search tool for the structure, property and function of biomolecules. 3DinSight consists of an integrated database, a set of search programs, a WWW interface and visualization tools. It has been open to public through the Internet. 3DinSight would help researchers to get insight into the relationship among the structure, property and function of biomolecules.
抄録全体を表示PDF形式でダウンロード (125K) -
上平 初穂, M. Michael Gromiha, 北島 浩司, 皿井 明倫原稿種別: 研究論文
専門分野: 情報学
2002 年 42 巻 6 号 p. 276-278
発行日: 2002年
公開日: 2002/11/23
ジャーナル フリー
We have developed the database, "ProTherm:Thermodynamic Database for Proteins and Mutants," which contains more than 11,000 numerical data for several important thermodynamic properties, structural information of proteins and mutants, experimental methods and conditions, and, functional and literature information. ProTherm can be searched through WWW on various conditions with different options for output. In addition, it is cross-linked with structure, function and literature databases such as PDB, PMD, ENZYME, SWISS-PROT, PIR and PubMed. The structure of mutation sites and surrounding residues can be directly viewed through 3DinSight, which is developed in our laboratory. ProTherm is freely available at above URL.
抄録全体を表示PDF形式でダウンロード (216K) -
皿井 明倫, Ponraj Prabakaran, M. Michael Gromiha, 北島 浩司, 上平 初穂原稿種別: 研究論文
専門分野: 情報学
2002 年 42 巻 6 号 p. 279-281
発行日: 2002年
公開日: 2002/11/23
ジャーナル フリー
Quantitative data of protein-nucleic acid interactions are important for understanding the molecular mechanisms of their recognition and gene regulation. We have developed the database, "ProNIT:Thermodynamic Database for Protein-Nucleic Acid Interactions", which contains numerical data for several experimental binding data, structural information of proteins, nucleic acids and the complex, experimental methods and conditions, and functional and literature information. A WWW interface allows users to search for data based on various conditions, and to visualize molecular structures, properties and their interactions. ProNIT is freely available at above URL.
抄録全体を表示PDF形式でダウンロード (211K) -
岩舘 満雄, 梅山 秀明原稿種別: 研究論文
専門分野: 情報学
2002 年 42 巻 6 号 p. 282-284
発行日: 2002年
公開日: 2002/11/23
ジャーナル フリーWe developed a computer program, FAMS (Full Automatic Modeling System) to build model structures based on reference structures solved using X-ray diffraction, NMR or other experimental methods, and amino acid sequence alignment between a target and its reference structure. Its ability was clearly shown in the CAFASP2 competition1). FAMS produces a model whose torsion angles of the backbone and sidechain are highly accurate. The processes of the FAMS algorithm are fully automated and therefore don't require any special knowledge, techniques or experience to obtain a biologically worthwhile protein structure.
抄録全体を表示PDF形式でダウンロード (38K)
解説
-
－異常拡散と階層的規則性－小松崎 民樹, 松永 康佑原稿種別: 研究論文
専門分野: 情報学
2002 年 42 巻 6 号 p. 285-289
発行日: 2002年
公開日: 2002/11/23
ジャーナル フリーThe observed kinetics of protein folding is a consequence of averaging over an ensemble of many activated barrier crossings with multiple time scales. The future of the recent remarkable experimental developments in single molecule spectroscopy holds great promise to reveal the complexity of protein folding dynamics. A few theoretical possible means to address and clarify the dynamical complexity such as abnormal diffusion of a protein are presented.
抄録全体を表示PDF形式でダウンロード (275K)
総説
-
下野 和実, 加茂 直樹原稿種別: 研究論文
専門分野: 情報学
2002 年 42 巻 6 号 p. 290-294
発行日: 2002年
公開日: 2002/11/23
ジャーナル フリーMany organisms including human beings have rhodopsin as photoreceptor. In cell membranes of archaeal Halobacterium salinarum, there exist four rhodopsin-like proteins (so-called archaeal rhodopsins). Two of these work as light-driven ion pumps. The other two work as photosensors and are named sensory rhodopsin (sR) and phoborhodopsin (pR). pR mediates the negative phototaxis. Recently, X-ray crystallographic structure of pR derived from Natronobacterium pharaonis is reported, and allows us to investigate the function-structure relationship at atomic level. In this review, we describe our results on the photochemistry and the signal transduction mechanism of pR.
抄録全体を表示PDF形式でダウンロード (146K) -
松本 美佐子原稿種別: 研究論文
専門分野: 情報学
2002 年 42 巻 6 号 p. 295-300
発行日: 2002年
公開日: 2002/11/23
ジャーナル フリーToll-like receptors (TLRs) are pattern-recognition receptors that play key roles in detecting microbes and initiating inflammatory responses. Ten members of the TLR family have been identified in humans. TLRs consist of an extracellular domain containing leucine-rich repeats and a C-terminal flanking region, and a cytoplasmic signaling domain, called the Toll/IL-1 receptor homology domain. Each TLR recognizes a distinct ligand (s) and induces different, sometimes overlapping, immune responses. Here, I show that TLR2 recognizes bacterial lipoproteins, while TLR3 recognizes virus-derived double-stranded RNA and triggers downstream signals leading to interferon production.
抄録全体を表示PDF形式でダウンロード (174K)
トピックス
-
林 文夫, 妹尾 圭司原稿種別: 研究論文
専門分野: 情報学
2002 年 42 巻 6 号 p. 301-304
発行日: 2002年
公開日: 2002/11/23
ジャーナル フリーPDF形式でダウンロード (353K)
実験技術
-
永井 健治, 宮脇 敦史原稿種別: 研究論文
専門分野: 情報学
2002 年 42 巻 6 号 p. 305-308
発行日: 2002年
公開日: 2002/11/23
ジャーナル フリーPDF形式でダウンロード (133K)
- |<
- <
- 1
- >
- >|