生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
40 巻 , 1 号
通巻227号
選択された号の論文の10件中1~10を表示しています
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  • 曽我部 正博
    2000 年 40 巻 1 号 p. 31-37
    発行日: 2000/01/25
    公開日: 2000/04/12
    ジャーナル フリー
    Cells show a variety of responses to mechanical stimuli which deform the cell membrane. In other word, cells can sense their shape change. However, the molecular mechanism of mechanosensation of the cell had remained unknown for a long time. This situation has been changed since the discovery of a mechanosensitive ion channel called stretch activated (SA) channel. The most popular type of SA channels is a Ca2+ -permeable type with a single channel conductance of ca. 40pS. Though we know little about their physiological functions in nonsensory cells, activation of SA channels may increase intracellular Ca2+ concentration, thereby elicits proper cell responses. This short article focuses on the recent progress in the SA channel-mediated signaling mechanism in the stretch-induced cell remodelling, where spatiotemporal structures of mechanical stresses are converted into the structure of cell.
  • 倉橋 隆
    2000 年 40 巻 1 号 p. 38-43
    発行日: 2000/01/25
    公開日: 2000/04/12
    ジャーナル フリー
    Olfactory signal transduction starts at the ciliary membrane of the receptor cells located in the olfactory epithelium. This transduction is triggerd by the G-protein-coupled seven transmembrane receptor, which in turn activates adenylyl cyclase-cAMP second messenger system. These chemical reactions finally lead to a sequential opening of cAMP-gated channel and Ca-activated Cl channel. Olfactory sensation is known to exhibit strong adaptation to the applied smell environment. This adaptation is regulate by a Ca-feedback to the cAMP-gated channel.
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