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Volume 34, Issue 2
Displaying 1-17 of 17 articles from this issue
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Toshio Fukasawa, Yutaka Yamaguchi, Hiroaki Saito1994 Volume 34 Issue 2 Pages 143-151
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFor specific and active immunotherapy in lung cancer patients, we established four anti-idiotype antibodies (Ab2β) to human monoclonal antibody 4G12 (IgM, λ) which reacts stronly with squamous cell lung carcinomas and other malignant tumors.
Murine splenocytes immunized with 4G12 monoclonal antibody were fused with mouse myeloma cells (P3U1) to establish anti-idiotype monoclonal antibodies. After repeated screening and cloning, we established four clones secreting IgG, κ monoclonal antibodies which specifically react with 4G12 antibody, but not with human IgM, IgG or serum. Inhibition assay showed that all of these antibodies inhibited about 90% of the binding reaction between 125I-labelled 4G12 antibody and human squamous cell lung cancer cells (PC10).
From these data, they were recognized to be Ab2β antibodies. Furthermore, cross-inhibition tests between each Ab2β antibody revealed that four Ab2β antibodies are recognized to reacting with at least three idiotopes of 4G12 antibody. When mice well immunized with each Ab2β antibody, anti-serum (Ab3 serum) was produced, and two of four Ab3 sera reacted with PC10 cells.
In conclusion, two Ab2β antibodies have internal image against 4G12 antibody, and might be useful for specific and active immunotherapy in lung cancer patients.View full abstractDownload PDF (3029K) -
Hirormto Inoue, Junichi Ogawa, Akira Shohtsu1994 Volume 34 Issue 2 Pages 153-159
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSImmunohistochemical expression of p53 was studied in relation to the expression of proliferating cell nuclear antigen (PCNA), the frequency of blood vessel invasion (BVI), and the disease-free survival in 351 patients with lung cancer, who underwent surgical resection. There were 166 stage I cases, 40 stage II, 104 stage III, and 41 stage IV. Concerning histologic type there were 177 adenocarcinomas, 135 squamous cell carcinomas, 24 large cell carcinomas, and 15 small cell carcinomas. Tumors with strong p53 expression had a significantly higher frequency of strong PCNA expression (P<0.01), and those with p53 expression showed a higher frequency of BVI (P<0.02). In adenocarcinomas, the frequencies of p53 and PCNA expression were significantly lower than in the other histologic types. The disease-free survival of cases negative for p53 expression was superior to those with weak or strong expression, although the differences were not significant. However, in adenocarcinomas, significant correlation was observed between the grades of p53 expression and the disease-free survival (P<0.05).View full abstractDownload PDF (851K) -
Kazuya Fukuoka, Takahiro Yoneda, Yoshizumi Kohnoike, Kohichi Tomoda, M ...1994 Volume 34 Issue 2 Pages 161-170
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe investigated lectin binding to normal bronchus and lung, metaplastic bronchial epithelium, and 42 cases of primary non-small cell lung carcinoma consisting of 23 squamous cell carcinomas and 19 adenocarcinomas. Fresh frozen sections were stained with 6 fluorescein isothiocyanate (FITC)-conjugated lectins of Dolichos biflorus (DBA), Ulex euro Paeus (UEA-I), Ricinus communis(RCA-I), Triticum vulgare(WGA), Canavalia ensiformis(Con A), Arachis hypogaea (PNA) and a microphotometer was used for objective evaluation of the fluorescence intensity. UEA-I, RCA-I, WGA, Con A, and PNA with the neuraminidase treatment (PNA·N (+)) were bound to most nontumorous bronchial and lung tissues, metaplastic bronchial epithelium, and lung carcinomas. However, the binding pattern of UEA-I differed from those of RCA-I, WGA, Con A, and PNA·N (+) in terms of localization of its binding sites. DBA was bound to nontumorous and metaplastic bronchial epithelium, bronchial glands, and a part of the bronchiolar epithelium and alveolar septum, but not to alveolar epithelium. The positivity of DBA binding to lung carcinomas was 61.9%(adenocarcinoma, 84.2%; squamous cell carcinoma, 43.5%); the positivity of adenocarcinoma being significantly higher than that of squamous cell carcinoma.
These results suggest that DBA is an important lectin for the analysis of differences of carbohydrate structures in cell surface membrane between nontumorous bronchus, lung, and the different histological types of non-small cell lung carcinomas.View full abstractDownload PDF (7529K) -
Yoshinori Kawabata, Toshihiko Sakai, Kazuo Fukushima, Seiji Mizutani, ...1994 Volume 34 Issue 2 Pages 171-180
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe frequency and mechanism of tissue defects seen in adenocarcinomas were examined pathologically. Sixty-four macroscopic tissue defect cases were seen among 428 resected tumors. The male: female ratio was nearly the same and the mean age was 57. The causes of tissue defect and their frequency were as follows: a) Cavity formation due to ischemia was seen in 20 cases, and these were mostly composed of poorly differentiated adenocarcinoma with massive necrosis; b) Cyst formation due to tissue destruction by cancer invasion was seen in 30 cases, and was composed of moderately and well differentiated ones; c) Stretch disruption due to mucus retention was found in 5 cases and was composed of mucous secreting cells; d) Cancer invading preexisting bullae or honeycombing was seen in 3 cases; e) Others accounted for 6 cases. By macroscopic and histological examinations, it was thought that well and moderately differentiated adenocarcinoma can cause destruction of lung structure through its growth, and it is the mechanism of cyst formation.View full abstractDownload PDF (7455K) -
Masahiko Ishibashi, Hideki Miyahara, Toshihiko Kohno, Hidemi Ohwada, Y ...1994 Volume 34 Issue 2 Pages 181-189
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSResected lungs obtained of residents of Okinawa, where lung cancer incidence is higher than other areas of Japan, were examined histopathologically and compared with several materials from residents of Chiba, where the incidence of lung cancer is relatively low. The lungs from Okinawa had multiple hyperplastic foci of distal airway epithelium and their degree of severity was high. Although the incidence of lung cancer among residents of Nagasaki in Kyushu was high, the frequency of hyperplastic foci of the lungs obtained from autopsy cases in Nagasaki was lower and the severity was less than in Okinawa residents. Therefore, the high incidence of hyperplastic foci is not specific to people in areas where lung cancer is more common, but to Okinawa residents. Hyperplastic foci were observed more frequently in the lungs with adenocarcinoma than in those with squamous cell carcinoma and atypical hyperplastic foci closely resembled adenocarcinoma histologically. The severity of hyperplasia increased with age. This tendency reflected the trend that the incidence of lung cancer increases with age. We could not demonstrate that the hyperplastic foci were precancerous lesions, but it was suggested that they might contribute to the occurrence of lung cancer. There was no relationship between smoking and the occurrence of hyperplastic foci and hyperplastic foci were also observed in the lungs of stray dogs in Okinawa. Therefore, unknown external causes are suggested to be involved in the high incidence of lung cancer in Okinawa.View full abstractDownload PDF (4854K) -
Katsuo Usuda, Yasuki Saito, Akira Sakurada, Yan Chen, Chiaki Endo, Sat ...1994 Volume 34 Issue 2 Pages 191-198
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA total of 65 resected cases of primary lung cancer were examined with regard to tumor doubling time (DT), argyrophil nucleolar organizer regions (Ag-NORs) and nuclear DNA content. Survival rates were compared among various categories according to each prognostic factor (univariate analyses), and significant factors affecting survival were determined by multivariate analyses using Cox's proportional hazard model. Univariate analyses showed significant differences in survival in relation to DT, smoking history, T factor, N factor, mean Ag-NOR counts, and DNA ploidy. Results of multivariate analyses proved that N factor, mean Ag-NOR counts, DNA ploidy and T factor were significant prognostic factors. There was a difference in biological significance between mean Ag-NOR counts and DNA ploidy. Mean Ag-NOR counts correlated to growth rate of tumor. DNA ploidy did not correlate with other prognostic factors, but was an independently significant prognostic factor.View full abstractDownload PDF (848K) -
1.Differentiation, Growth Pattern and Interstitial ChangeNaoya Koizumi1994 Volume 34 Issue 2 Pages 199-207
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe thin-section CT images of 18 patients with pulmonary adenocarcinoma were compared with the histological structure of the resected specimen with paticular emphasis on growth pattern and interstitial change. The thin-section CT images were classified into six kinds of domains (D1a, D1b, D2a, D2b, D3a, D3b) from the point of density (1: homogeneously low, 2: nonhomogeneous, 3: homogeneously high) and shape of the margin (a: smooth, b: irregular), which resulted in 52 domains (D1a; 7 domains, D1b; 7 domains, D2a; 11 domains, D2b; 7 domains, D3a; 8 domains, D3b; 12 domains). D1a corresponded to bronchioloalveolar type of well-differentiated adenocarcinoma with mild interstitial change. Interstitial changes became prominent in order of D1, D2, D3. Various growth patterns were noted in D2 and D3a. D3b showed severe interstitial changes which might suggest poor prognosis.View full abstractDownload PDF (10364K) -
Akira Masaoka, Ichiro Fukai, Yutaka Ariyoshi, Yasuaki Naito, Takayuki ...1994 Volume 34 Issue 2 Pages 209-221
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe clinical usefulness of cytokeratin 19 fragment (CYFRA 21-1) as a tumor marker for lung cancer was investigated. In 273 healthy subjects, serum CYFRA 21-1 level was 0.6±0.5ng/ml (mean±SD), and there was no correlation between serum CYFRA 21-1 levels in relation to sex or age. When the upper limit of the normal level was fixed at 2.0ng/ml, the specificities for healthy subjects and non-malignant lung disease were 98.5% and 90.8%, respectively. The positive rate of serum CYFRA 21-1 was 43.0%(139/323 cases) in primary lung cancer. Histologically, the positive rate was 63.3%(76/120 cases) in the squamous cell carcinoma group, 28.8%(38/132 cases) in the adenocarcinoma group, 45.0%(9/20 cases) in the small cell carcinoma group, 35.0%(7/20 cases) in the large cell carcinoma group and 45.5%(5/11 cases) in the adeno-squamous cell carcinoma group, showing statistical differentiation between the squamous cell carcinoma group and the others. In relation to the clinical stage of squamous cell lung carcinoma, the positive rate was 40.6%(13/32 cases) in the stage I group, 54.5%(6/11 cases) in the stage II group, 82.4%(14/17cases) in the stage IIIA group, 85.7%(6/7 cases) in the stage NIB group and 75.0%(6/8 cases) in the stage N group. With regard to serum CYFRA 21-1 level and T-, N-, M-factors or tumor size in primary lung cancer, serum CYFRA 21-1 levels were significantly higher as each factor became progressively worse. When the levels of serum CYFRA 21-1 before and after curative surgery and radiotherapy were compared, post-treatment serum CYFRA 21-1 levels were found to be significantly lower. In advanced or recurrent cases, follow-up of serum CYFRA 21-1 reflected the efficacy of treatment. These results show that CYFRA21-1 is useful as a serum tumor marker for lung cancer.View full abstractDownload PDF (1358K) -
Kazuhito Dobashi, Hisashi Nakahashi, Takashi Yoshimatsu, Yoshio Horiuc ...1994 Volume 34 Issue 2 Pages 223-228
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThirteen cases of subxiphoid pericardiotomy for primary lung cancer with pericarditis were observed during the period from September, 1986 to July, 1992. Seven cases were males and 6 were females. The average age was 59.5 years. Eleven cases were diagnosed as adenocarcinoma and two as small cell carcinoma. In the operation, 7 out of 13 cases received treatment by only removal of pericardial effusion and the remaining six cases also had local instillation of antineoplastic agents (THP-ADM) after drainage. There was no postoperative complication. Postoperative survival time ranged from 15 to 420 days and the median survival time was 64 days. There was no significant difference in the prognosis between the operation with and without local chemotherapy (THP-ADM). Six out of 13 cases could leave hospital after operation and their survival time after discharge ranged from 24 to 213 days with a mean of 91 days. There was no recurrence of cardiac tamponade. In the cases who lived for more than thirty days after removal of the drainage tube, the response rate was 100%. The cause of death in all cases was cancer, and respiratory failure caused by carcinomatous lymphangiosis was the main factor affecting the prognosis. We suggest that subxiphoid pericardiotomy is one of the most effective and safe therapeutic method for pericarditis associated with primary lung cancer.View full abstractDownload PDF (734K) -
Hiroyuki Nakamura, Yasufumi Yamaji, Jiro Fujita, Keiichi Takigawa, Yos ...1994 Volume 34 Issue 2 Pages 229-235
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA prospective randomized clinical trial was conducted to test whether the preventive use of rh G-CSF obtain better results than the conventional use of rh G-CSF for chemotherapy-induced neutropenia in lung cancer patients. A total of 26 patients, 22 of whom were evaluable, were entered in this study and were assigned to two groups. In Arm A (conventional use of rh G-CSF), subcutaneous (s. c.) administration of rh G-CSF at a dose of 50μg/m2was given to the patients when the neutrophil counts became 2, 000/μl or less, whereas in Arm B (preventive use of rh G-CSF), s. c. administration of rh G-CSF at the same dose was fixed at days 4 to 18. All patients received the same chemotherapy consisting of 300mg/m2carboplatin at day 1, 30mg/m2adriamycin at day 1, 100mg/m2etoposide at days 1 to 3 by drip infusion.
Significant differences were observed in terms of mean neutrophil nadir (1, 547/μl in Arm B vs. 205 in Arm A; p<0.01) and the mean duration of neutropenia (<1, 000/μl: 2.0 days in Arm B vs. 5.6 days in Arm A; p<0.01). Also Arm B showed a tendency to shorten the mean duration of neutropenia with fever (>37°), days of administration of antibiotics and to reduce the episodes of infection.
In conclusion, the preventive use of rh G-CSF may be effective to shorten the interval between chemotherapeutic cycles and to increase the tolerable dose intensity in lung cancer chemotherapy as compared to the conventional use of rh G-CSF.View full abstractDownload PDF (726K) -
Shuhei Inoue, Yuji Suzumura, Kentaro Takahashi1994 Volume 34 Issue 2 Pages 237-242
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 71-year-old male was admitted to our hospital from another hospital, and hemosputum and an abnormal shadow on his chest X-ray were pointed out. We diagnosed the abnormal shadow with cavitation as lung cancer, and performed right lower lobectomy. 6 units of CRC and 10 units FFP were used during the operation. The postoperative course was good but he developed a high fever on the 11th day after operation.
He then developed systemic erythroderma on the 13th day after operation and died on the 23rd day as a result of diarrhea, liver dysfunction, pancytopenia, sepsis and acute renal failure. Bone marrow aspiration showed hypoplastic findings. Based on the clinical picture and bone marrow biopsy, we made a diagnosis of post-transfusion GVHD-like syndrome. Use of irradiated blood is advised to prevent the occurrence of this fatal complication. This case is the first report of post-transfusion GVHD-like syndrome after lung lobectomy.View full abstractDownload PDF (7664K) -
Samon Miyata, Hiroshi Demachi, Saburou Izumi, Hirofumi Noto, Kazuhiro ...1994 Volume 34 Issue 2 Pages 243-247
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 39-year-old woman was admitted with hemoptysis. The chest X-ray film showed consolidation of left S6. The plain CT demonstrated atelectasis of S6, and a slightly homogeneously enhanced 2.5cm round mass in the proximal portion of the left B6 was visualized on dynamic enhanced CT. Bronchoscopic examination revealed a round polypoid endobronchial mass at the orifice of left B6, partially occluding the lower lobe bronchus. Suspecting carcinoid or bronchial gland carcinoma, sleeve resection of the B6 bronchus with S6 segmentectomy was performed. Macroscopic findings of the resected specimen showed a 2.5×2×2.7cm solid mass in the proximal portion of the left B6, with lobulated endobronchial growth. Histologically the tumor was monomorphic adenoma of the bronchus. The patient is alive and well with no evidence of tumor recurrence 2 years 6 months after the operation.View full abstractDownload PDF (6317K) -
Yuka Sasaki, Fumio Yamagishi, Kiminori Suzuki, Kazutoshi Sugito, Junic ...1994 Volume 34 Issue 2 Pages 249-253
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 68-year-old female was admitted to our hospital because of cough. Chest roentogenogram showed an anterior mediastinal tumor. CT scanning showed two tumors on the posterior chest wall, one suspicious of pleural dissemination, and one suggesting rib metastasis. Transcutaneous biopsy specimen from an anterior mediastinal tumor revealed thymoma. The clinical stage was IVb, so she was treated with repeated combination chemotherapy. However, the tumor did not reduce the size. After 3 months, she came to our hospital as an emergency case because of dyspnea. Her blood laboratory data showed pure red cell aplasia. She did not recover after blood transfusion and steroid pulse therapy, and died due to heart failure on the sixth day.View full abstractDownload PDF (3534K) -
Hideaki Ichikawa, Ichiro Yoshida, Tsunehiro Ishida, Hitoshi Kodama, Su ...1994 Volume 34 Issue 2 Pages 255-259
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 64-year-old woman underwent subtotal thyroidectomy for papillary thyroid carcinoma 8 years previously. A solitary nodular shadow was recognized on chest x-ray films and malignant tumor was suggested by bronchial arterial angiograms. A solitary nodular metastasis to the lung from the papillary thyroid carcinoma was identified by exploratory thoracotomy. We reported a rare case of metastatic lesion of the lung in a patient following resection of papillary thyroid carcinoma.View full abstractDownload PDF (6135K) -
Kazuhiko Kataoka, Noritomo Seno, Motoki Matsuura, Masao Doi, Teruomi M ...1994 Volume 34 Issue 2 Pages 261-266
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 21-year-old female was admitted because of fever and right shoulder pain. An anterior mediastinal tumor with central necrosis was revealed by chest X-ray, CT and MRI. Ring-shaped abnormal uptake was shown by Ga-scintigraphy. Median sternotomy revealed a tumor originating from the right lobe of the thymus and invading the right upper lobe of lung and pericardium. The tumor was resected with partial resection of the lung and pericardium. Microscopically, the tumor was composed of large round cells. Immunohistochemically, the cells positively stained with leukocyte common antigen (LCA) and L-26. Diffuse large B cell lymphoma was diagnosed. Primary mediastinal diffuse large B cell lymphoma has recently been recognized as a distinct clinico-pathological entity. Only 16 cases have been reported to date in the Japanese literature. This patient had intensive chemotherapy by hematologists in another hospi-tal. This disease must be treated by aggressive therapy.View full abstractDownload PDF (7129K) -
Ryo Okano, Masato Sekiguchi, Takeo Uraguchi, Yushiro Kuratomi, Shigeki ...1994 Volume 34 Issue 2 Pages 267-273
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe report a case of adenocarcinoma of the lung that was strongly suggested to have produced alpha-fetoprotein (AFP). Sputum cytology and TBLB showed adenocarcinoma. Serum AFP was 230ng/ml and the concentration of AFP in sputum was 120ng/ml. Liver cirrhosis, hepatocellular carcinoma, carcinomas of gastrointestinal tract, mediastinal tumor and testicular tumor were excluded in the present case. These results indicated the present case to be a primary lung cancer producing AFP.
The concanavalin A (Con A) non-reactive fraction rate for serum AFP was 56%. The lentil agglutinin (LCH) strongly reactive and weakly reactive subfraction were 36% and 50% respectively.
In summary, our case and 13 previously reported cases in Japan in which AFP was produced by primary lung cancer did not have uniform affinity for Con A and were seemed to have LCH binding properties. These results resembled those of yolk sac tumor and gastrointestinal carcinomas.
At present, we consider that the study of lectin affinity of AFP does not have any obvious clinical significance to differentiate primary lung cancers from metastatic malignant tumors.View full abstractDownload PDF (5553K) -
1994 Volume 34 Issue 2 Pages 275-293
Published: April 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (2538K)
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