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Volume 13 (1973)
- Issue 4 Pages 303-
- Issue 3 Pages 145-
- Issue 2 Pages 67-
- Issue 1 Pages 1-
Volume 13, Issue 1
Displaying 1-6 of 6 articles from this issue
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Toshio Kato, Nobuo Koike, Hideo Niibe, Koji Sakaino, Tatsuo Tobe1973 Volume 13 Issue 1 Pages 1-7
Published: March 25, 1973
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSOut of 239 lung cancer patients seen during 12 years from Apr.1959 through May 1971, twenty-eight (11.7%) were small cell anaplastic carcinoma of stage III and IV. (Fourteen patients for each stage)
It was possible to point out the biological characters of this type of tumor;rapidly growing, early metastasizing and with very high radiosensitivity.
On these bases, primary lesion was irradiated with two opposed fields, usually including hilar and mediastinal nodes.On occasions with distant metastases, these lesions were irradiated as widely as possible to alleviate their complains.Regression of tumor was excellent and followed transient remission with relatively small dose of radiation.
Both survival rate and mean survival time of small cell carcinoma were inferior to those of other histologic types.Longest survivors among 15 patients treated by radiotherapy alone, with more than 5, 000 rads, were 3 patients died 14 months after the start of radiotherapy, and the mean survival of this group was 6.7±4.6 months.
Radiotherapy combined with cytotoxic drugs would be the standard treatment of small cell carcinoma of the lung at this moment.View full abstractDownload PDF (842K) -
Resected Specimens with Secondary Lung Cancer with Special Reference to Incipient Metastasis Formation in LungTsutomu Takahashi1973 Volume 13 Issue 1 Pages 9-19
Published: March 25, 1973
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSHistopathological studies on the incipient metastasis formation were made on the specimens of 23 cases with surgical resection for secondary lung cancer.
There were found 15 cases with microscopic metastases following the histological examination on the area without any visible macrometastases of resected specimens.The growth of tumor cells was observed in eight cases in the tissue spaces adjacent to small blood vessels, in three within small blood vessels and those surrounding tissues, and in one within terminal bronchiole.In the remaining three cases the growth sites of tumor cells were undetermined.
From our results of animal experiments on the initial formation of pulmonary metastases via haematogeneous route, the small blood vessels were considered to be venules when cancer cells proliferated in those surrounding tissues, and to be arterioles when cancer cells proliferated both within and surrounding tissues of those vessels.
The above results will mean that initial pulmonaly metastasis via haematogeneous route in humanbeings as well as in animals, might be formed not only by the growth of tumor cells embolised in arterioles or capillaries but also by the growth of tumor cells extravasated from venules.View full abstractDownload PDF (2990K) -
A study on the development of abrasive cytology through the flexible-bronchfibrerscopeRyosuke Ono1973 Volume 13 Issue 1 Pages 21-40
Published: March 25, 1973
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSWith the remarkable progress and development of the diagnostic techniques of lung cancer, numerous studies and researches have been achieved in this field in recent times.Of those technicalities, major methods which have been in wide parctice include three examinations, chest X-ray, bronchoscopic examination and cytology.In the advancement of those techniques these have been made use of in the manner in which they conpensate their shortcomings and make the most of their strong points, mutually towards perfection step by step.It is in the fields of bronchoscopic examination that has recently marked a definitely specific development among the above three techniques.
The newly developed apparatus, flexible bronchofiberscope, brought about four advantages which lacked in the traditional rigid bronchoscope: the pronounced expansion of visualized field in the bronchus, the maximum abatement of discomfort on the patient all through the examination, an expanded possibility of cytology under direct vision, and the diffusion of bronchoscopic examination.To go a little further, the extension of the visualization in particular has brought forth a striking increase in the rate of lung cancer findings: newly designed biopsy attachments to the bronchofiberscope for cytology, completely unlike the traditional examination, have made histodiagnosis possible in the remote lesions located in the hitherto impossible peripheral bronchi;the biopsied material obtained by abration under direct vision and X-ray TV system is of fresh cells entirely different from those desquamated and degenerate cells obtained from the sputum which used to be the only basis for the traditional cytodiagnosis.It had been considered to be re-examined by comparing fresh cells with degenerate cells.View full abstractDownload PDF (3316K) -
Isao Sasaki1973 Volume 13 Issue 1 Pages 41-51
Published: March 25, 1973
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSWe treated 139 patients with primary lung cancers by CO-60 from 1964 to 1971.The size of single dose was 600R twice a week and therefore 1200R in a week-dose.The total of dosage used was from 6000R to 8400R over a period from 5 to 7 weeks in most cases.
As control, 148 patients treated by daily dose of 200R six times per week were compared with this trial.
The consequence of our studies was evaluated by crude survival rate, median survival months and tumor regression rate.The procedure of 600R twice a week has a better therapeutic effect than control.
As to side effects we checked local and general side effects.In regard to skin reactions, erythema and dry reactions occured in most cases, but moist reactions occured in only 2 cases.
Pulmonary pneumonitis has been seen in about 60% of cases between the end of and 3 months after the treatment.In the cases of delivering 8000R or more, pneumonitis occured in almost all the cases within 2 months from the beginning of treatment.But, administration of medicines eliminated severe symptoms due to pneumonitis or fibrosis.
White cells were examined once a week in all cases, 3000/mm3 of white cells were regarded as a minimal for further irradiation.White cell counts of more than 4000 were 54.9%, 4000 to 3000 40.7%, and below 3000, 4.4% respectively.
Thrombocytes below 100, 000/mm3 were seen only in a few, and red cells showed no appreciable change.
Tumors were regressed approximateoy the same degree by both types of treatments without conspicuous side effects.
In addition, in our procedure anti-tumor drugs and hyperbaric oxygen therapy can be utilized relatively easily during unirradiated time.View full abstractDownload PDF (1533K) -
1973 Volume 13 Issue 1 Pages 52-55
Published: March 25, 1973
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSDownload PDF (424K) -
1973 Volume 13 Issue 1 Pages 57-62
Published: March 25, 1973
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSDownload PDF (812K)
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