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Volume 22 (1982)
- Issue 5 Pages 499-
- Issue 4 Pages 389-
- Issue 3 Pages 225-
- Issue 2 Pages 117-
- Issue 1 Pages 1-
Volume 22, Issue 2
Displaying 1-10 of 10 articles from this issue
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Field Study ResultsKatsutoshi Yoshimura, Nobuo Yamashita1982 Volume 22 Issue 2 Pages 117-126
Published: June 30, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe results of 4, 931 lung cancer cases treated during 1970-72, were examined to evaluate the factors influencing the prognosis of lung cancer.
The background factors examined included T-factor, N-factor, M-factor, TNfactor, clinical stage, histological type, age and sex. The prognosis was also examined according to method of treatment. The five year survival rate in the curative resection only group was 42.6%, in curative resection + chemotherapy, 52.1%, in curative resection + chemotherapy + immunotherapy 54.8% and in curative resection + irradiation+ chemotherapy 49.4%.
The improvement of results of 5-year survival rate in cases with lung cancer by multi-modality were expected.
These results suggest improved 5-year survival by multimodality treatment.View full abstractDownload PDF (827K) -
Yasuo Komuro1982 Volume 22 Issue 2 Pages 129-138
Published: June 30, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo estimate the histological changes of pleura caused by sclerosing agents, anticancer agents such as ADR, MMC, ACM, CQ, BLM, ACNU, VDS, and Doxycycline were administered into the right pleural space of New Zealand white rabbits. The animals were sacrificed from. 1 hr to 5 weeks after administration, and parts of visceral and parietal pleura were used for hemotoxylin and eosin staining after the amount of pleural fluid was measured. ADR and MMC caused accumulation of pleural effusion dosedependently and particularly MMC produced hemorrhagic fluid. Histologically the mesothelial cells of pleura were destroyed nearly completely after injection of ADR or MMC, followed by proliferation of fibroblasts with time, which led to thickening of the pleura. The other agents did not destroy the mesothelial cells, but caused hyperthrophy. These findings might support our clinical results suggesting that the intrapleural administration of ADR in patients with carcinomatous pleurisy is more effective than any other agent.View full abstractDownload PDF (13025K) -
Khaled Reshad, Morihisa Kitano, Akira Fujio, Osamu Ike, Yoshiki Takeuc ...1982 Volume 22 Issue 2 Pages 139-151
Published: June 30, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe incidence of tumor cells in pleural effusions, their disappearance after treatment and their relationship to survival time were studied in 148 cases (including 93primary lung cancer and 55 metastatic pleurisy cases).
The positive rate of tumor cells in pleural effusion was 73%, while the negative rate after treatment was 65% in primary pleurisies, and 80% in metastatic pleuritic cases. The effects of systemic chemotherapy and thoracocentesis or tube thoracostomy with local instillation of anti-cancer drugs were also evaluated. Tube thoracostomy and local instillation of anticancer agents and talc were more effective than thoracocentesis or systemic chemotherapy alone.
We have performed contrast thoracography after pleurodesis through the intrathoracic drain. The border of the adhesion was verified by change of position under fl uoroscopy. It is thought to be the best method for confirming the extent of adhesion after pleurodesis and deciding the most suitable time for removing the intrathoracic drain.
Also in this study the permeability status of the pleural space was evaluated in 42 carcinomatous pleuritic cases. The sequential changes of concentrations of MMC and ADM in blood were measured following intrapleural instillation in 27 cases, and pleural fl uid levels of MMC, ADM, CPA and FT were examined in 15 cases after systemic infusion. In patients without thickened pleuras, the permeability of the drugs was rapid, however in thickened pleural cases the permeability of the pleura was in inverse proportion to its thickness. Therefore in cases with thickened pleura the local instillation of the anticancer agents was more effective.
The level of glucose in pleural effusions of 60 cases was examined. It was quite low in cases of thickened pleura, however a high level of glucose as in serum was seen in normal cases. Therefore, the glucose level of the pleural fluid can be used as a marker of the pleural thickening.View full abstractDownload PDF (3800K) -
Minoru Kurihara, Norihiko Hayakawa1982 Volume 22 Issue 2 Pages 153-164
Published: June 30, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe age-adjusted death rates for lung cancer have markedly increased in many countries. Observing by age group, however, the death rates have begun to decrease in the younger population in many countries except Japan. The trends in morbidity incidence rates for lung cancer also showed decline in younger ages, especially among males, in some countries. These facts suggest that the exposure to risk factors of lung cancer has declined in such countries.
The age-adjusted death rates for lung cancer and the increasing rates of those death rates were observed in prefectures in Japan, and it was found that the geographical difference in the incidence of lung cancer was decreasing in Japan.View full abstractDownload PDF (1166K) -
Minoru Tatsuda, Harumichi Ikegami, Takeshi Horai, Shinichiro Nakamura1982 Volume 22 Issue 2 Pages 165-173
Published: June 30, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFive hundred and seventy-three needle aspiration biopsies were carried out on 504 patients with lung lesions. Of 221 confirmed primary lung cancer cases, 190 (86.0%) were proven to be malignant. In a smaller series of lesions less than 2 cm. in diameter, a correct diagnosis was established in 80% of lung cancer cases. As the results of reevaluation of cytologic smears from lung cancer which had received a false negative diagnosis, the reason for this, in a large number of cases, was the lack of carcinoma cells in the aspirates. That is, the aspiration technique was considered to be unsuccessful in those cases. A false positive diagnosis of cancer was made in 4 cases of these biopsies. A correct diagnosis of histological type was made in 80% of the cases with positive aspiration biopsy in lung cancer.No differences in five-year survival was found between lung cancer patients who had aspiration biopsy and their matching controls. There was no evidence of spread of tumor through the needle tract. This method is also extremely safe in view of the very low complication rate.
Therefore, this method is considered to be the most valuable in the diagnosis of peripheral lung cancer, and should be used earlier to shorten the interval required for the diagnosis of lung lesions.View full abstractDownload PDF (934K) -
Noriaki Tsubota, Kosaku Maeda, Satoshi Okada, Nobuyuki Takahashi, Kosh ...1982 Volume 22 Issue 2 Pages 175-179
Published: June 30, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 49-year old man who had been treated for asthma for several years complained of dyspnea and repeated attacks of pneumonia. On bronchoscopy, the left main bronchuswas completely occluded by a round yellow tumor. A tentative diagnosis of adenoma was made.
Left thoracotomy was performed. The posterior aspect of the left main bronchus was exposed and bronchotomy up to the segmental bronchi displayed a polyp 5 cm in length, which was found to originate from B4a bronchus, R. lingularis superior Rm lateralis, down to the left main bronchus. The long bronchotomy was closed by 3-0 Dexon, followed by lingulectomy. Recovery was uneventful.On histological examination, the tumor covered by normal bronchial epithelium was composed of adipose tissue, smooth muscle and vascular tissue, which was considered atypical hamartoma-noncartilage endobronchial type.View full abstractDownload PDF (7012K) -
A Case Report and Review of the LiteratureKeiichi Mikasa, Hitoshi Katada, Fumio Shirai, Kazuhiko Miyataka, Riich ...1982 Volume 22 Issue 2 Pages 181-189
Published: June 30, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 51-year-old male, exposed to asbestos for 24 years, was admitted because of the abnormal findings of the chest roentgenogram. Chest X-ray film showed tumorous shadow on the right diaphragm in the right lower lung and no findings of asbestosis. Fine crackles were audible on late inspiration at the bilateral posterior lung base. Needle biopsy of the lung tumor revealed adenocarcinoma of the lung.
Right lower lobectomy was carried out. The tumor in the right lower lobe (S10) measured 4 × 5 cm, in diameter. Histologically, the tumor was braonchiolo-alveolar cell carcinoma and the surrounding tissue showed moderate alveolitis. Numerous asbestos bodies were present in the area of alveolitis.
So far, few resected cases of asbestos-related lung cancer have been reported. The clinicopathological features of asbestos-related lung cancer are discussed.View full abstractDownload PDF (13693K) -
Teruhiko Imai, Hitoshi Katada, Shinji Fujiki, Nobuhiro Narita, Riichir ...1982 Volume 22 Issue 2 Pages 191-198
Published: June 30, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 42-year-old male, exposed to asbestos for 20 years, was admitted complaining of cough, fever and dyspnea. The characteristic finding of the chest roentgenogram was a tumorous shadow in the right upper lung field, in addition to the findings of asbestosis. Mycobacterium tuberculosis were detected in sputum. Ferruginous bodies were also isolated from sputum. Cytological diagnosis of the sputum and percutaneous needle biopsy of the lung was poorly differentiated adenocarcinoma. After conservative treatment of approximately 6 months duration, he died of cor pulmonale.
Autopsy confirmed the diagnosis of poorly differentiated adenocarcinoma with moderate asbestosis. The pathological examination of the specimen revealed an incipient tuberculosis lesion but no active tuberculous lesion.
The intercorrelation between pulmonary asbestosis, bronchogenic carcinoma and pulmonary tuberculosis was discussed.View full abstractDownload PDF (13446K) -
1982 Volume 22 Issue 2 Pages 199-201
Published: June 30, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (265K) -
1982 Volume 22 Issue 2 Pages 203-221
Published: June 30, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (2822K)
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