X-ray findings of peripheral lung cancer were observed in detail under consideration to the histologic change on 34 tumors sized 2 cm or less in diameter with 33 tumors sized 2.1 cm to 3.0 cm.45 adenocarcinoma, 12 epidermoid carcinoma and 10 undifferentiated carcinoma were included in the total cases.
1.The radiological findings of small peripheral lung cancer were classified into three major types, i.e., Tumorous type, Conglomerating type and Infiltrative type, and cavitary shadows were noted in addition.
Tumorous type was classified into 4 subtypes, a) round, b) mulberry-like, c) on-pleural and d) irregular polygonal. Conglomerating type was divided into 2 subtypes, a) nodularly conglomerating and b) granularly conglomerating, and infiltrative type into two;a) pure infiltrative and b) infiltrative with strand. (Fig.1).
2.Regarding pulmoalveolar and papillary adenocarcinoma, most of the cases showed infiltrative shadow, while some of them revealed tumorous density, the border of which were not so sharp and showed somewhat infiltrative nuance on plane film.On tomogram, unevenness on the density of tumorous shadow or accompanying strand and/or string shadows were noted.
3. As for tubular and acinor adenocarcinoma, most cases showed sharply defined tumorous density, or relatively deep notchings like a clover, and were accompanied with radiated strand shadow on either plane film or tomogram in many cases.In low differenciated adenocarcinoma, the tumor tend to show round shape.
4. Commonly to all the subtypes of adenocarcinoma, air bronchogram was observed frequently.
5. It was felt difficult to discern epidermoid carcinoma from undifferenciated carcinoma on the radiological findings.Epidermoid carcinoma, sized under 2 cm, revealed round shadow of mostly well defined margin, but when exceeded 2 cm in diameter, it showed shallow and relatively smooth notchings which looked like a potato in many of the cases, or many strand shadows running along bronchi or pulmonary vessels in some of them.
6. As for undifferenciated carcinoma, some cases showed saw-toothed-like border, while the others had well-defined tumorous shadow with relatively smooth notchings simillar to those of epidermoid carcinoma.
7. In the early stage of epidermoid and undifferenciated carcinoma, granularly conglomerating type appeared.
8. The border of the tumor tended to be hazy, when tuberculous lesions were present around the tumor.
9. In the small peripheral lung cancer, cavitary shadow was found oftener in adenocarcinoma than in the others.

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Volume doubling time of lung cancer was measured in30resected cases and its relations to histological findings and to some clinical aspects were discussed.
Epidermoid carcinoma and undifferentiated carcinoma showed rapid growing in most cases (mean doubling time was 72 and 64 days respectively), but adenocarcinoma showed a wide variation of growth rate from rapid to extremely slow (54 to 1430 days, mean 407 days). Histological growing mode had a high correlation with growth rate. The cases with alveolar wall destroying type or expansive alveolar space filling type showed rapid growing in79%and none of them showed slow growing, but the cases with alveolar septum lining type showed slow growing in 73% and none of them showed rapid growing. Cases with nonexpansive alveolar space filling type laid between them.
Histological structural and cellular atipism (SAT & CAT) had a correlation with growth rate: cases with high degree of atipism showed mostly rapid growing and cases with low degree of atipism mostly slow growing.Degree of histological infiltration of cancer to the surrounding lung tissue (INF) had no relation to growth rate. Lymphocyte infiltration in the stroma of cancer had a tendency to be high degree in most of the cases with slow growing, but degree of fibrous proliferation of the stroma had no relation to growth rate. Necrosis was seen in higher percentage in the faster growing group, but cavitation which was seen in 17% of all cases showed no relation to growth rate. Pleural indentation was seen in about 50% of all cases, but it had no relation to growth rate.
The cases with a shadow showing sharp margin and homogenous density on tomogram showed rapid growing in 78% and the cases having a shadow with moderately sharp margin and homogenous density showed rapid growing in 50%. On the contrary the cases having a shadow with moderately sharp margin and nonhomogenous density with small irregular airations showed slow growing in 66%, and the cases having a shadow with hazy margin and nonhomogenous density showed slow growing in all.
Among the cases with rapid growing the postoperative prognosis was good in epidermoid carcinoma, but it was poor in undifferentiated carcinoma and adenocar cinoma.Cases with slow growing showed good prognosis in all cases, and most of them were alveolar septum lining adenocarcinoma.
From the histological and clinical features adenocarcinoma of the lung can be divided roughly into two groups.The first group is histologically the alveolar space filling type and clinically rapid or moderate growing with relatively poor prognosis. The second group is histologically the alveolar septum lining type and clinically slow growing with good prognosis.

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The effect of BLM was evaluated in the study of the experimental lung cancer by the administration of MNU.One hundred and twenty rats of Wistar strain, in which MNU was administrated intraperitoneally for 6 months, were divided into four groups; the group administrated 22 times of 0.375mg/rat of BLM in the middle stage of experiment (Group-AI), the group administrated 22 times of 0.375mg/rat of BLM in the latter stage of experiment (Group-AII), the group administrated 39 times of 0.375mg/rat of BLM in the middle to latter stage of experiment (Group-AIII) and the control group without the administration of BLM (Group-AIV).All rats were sacrified after 7 months, and 80 of the 120 rats were appraised.No significant differences between the 4 groups were demonstrated in the mortality, the increasing rate of body weight, and the incidences of tumor development in rats.However, in Groups AII and AIII, in which BLM were continously administrated just before the sacrifice, the degeneration, the necrosis of the neoplasia (the squamous cell carcinoma or ademona), and the fibrosis of the necrotic portion were demonstrated more frequently as compared with those in Groups Al or AIV. this finding might imply that BLM would suppress the tumor-growth. Moreover, the diffuse interstitial pulmonary fibrosis occurred by the administration of MNU, but BLM did not accelerate the fibrosis.

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Out of239lung cancer patients seen between Apr. 1959and May 1971, 158were irradiated curatively (more than5, 000rads), 38were irradiated palliatively and 43 were treated conservatively.
Analysis of age, sex and symptom of all patients according to stage (Japan Lung Cancer Society) and histology (WHO) clarified the actual status of lung cancer refered to radiotherapy. Only one thirds of them were classified as stage I or II.
Treatment results of 158 patients irradiated curatively were as follows.
There were 3 patients survived more than five years.Prognosis of patients in stage I was most favourable, stage II was in the next place and there was significant difference between stage III and IV. Mean survival time (months) in each stage and crude survival rate (%) of overall patients of this group were: 27.5±18.4 in stage I, 16.1 ± 13.1 in stage II, 8.4 ± 6.3 in stage III and 6.7 ± 8.2 in stage IV; 30.5 for 1 year, 12.4 for 2 year, 7.7.for 3 year, 4.2 for 4 year and 2.1 for 5 year, respectively.

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An autopsy case of small scar cancer of the lung in a 46-years old man sufferring from coal-worker's pneumoconiosis was presented and described the histogenesis of this tumor.
Present study was apparently exhibited the transition of normal bronchiolar epithelium or adenomatous hyperplasia of bronchiolar and alveolar cells to adenocar cinoma arising in subpleural scar tissue. Scar carcinoma of the lung may possibly not be of bronchiolar origine but also of alveolar cell origine as well as adenomatous hyperplasia.

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A rare evidence of extreme long intraluminal processes in the capillaries of human lung cancer was observed with the electron microscope. The longest process was 6u in lengths.

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