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Volume 38, Issue 2
Displaying 1-14 of 14 articles from this issue
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Ryuta Sasamoto, Naoya Koizumi, Kunio Sakai, Yoshinori Kihara, Tomoo Sa ...1998 Volume 38 Issue 2 Pages 99-107
Published: April 20, 1998
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe retrospectively compared the specimens of CT guided percutaneous lung biopsy with the specimens surgically resected later in 17 cases with small adenocarcinoma of the lung to investigate the possibility of preoperative prediction of the Noguchi type pathological classification.
The coincidence rate was 41.2%(7/17). It was considered difficult to guess the Noguchi type of small adenocarcinoma of the lung preoperatively by CT guided percutaneous lung biopsy. In this study, one resected specimen contained linearly-arranged fibrosis and fibroblasts suggesting the sequelae of lung biopsy. It seemed to be important to pay attention to the possibility of fibrosis resulting from biopsy in classifying the Noguchi type.View full abstractDownload PDF (7536K) -
Yasushi Yamato, Takahiro Souma, Katsuo Yoshiya, Masanori Tsuchida, Tad ...1998 Volume 38 Issue 2 Pages 109-115
Published: April 20, 1998
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTwenty-eight pulmonary bronchiolo-alveolar type adenocarcinoma with minimal fibrotic foci resected from 1987 through 1996 were reviewed retrospectively. They consisted of 9 men and 19 women with a mean age of 64.7 years. Twenty-four patients underwent lobectomy and four underwent wedge resection. Chest roentgenogram and computed tomography showed that the tumors had a distinct or indistinct boundary and homogeneously low density with a mean tumor diameter of 21.9 mm (range 12-35 mm). Histopathologically, these tumors showed a growth pattern of replacement of alveolar epithelial cells with minimal fibrotic foci. No tumors showed vessel invasion, lymph node or intrapulmonary metastasis.
Twenty-six patients are alive without reccurence and 17 of them have survived more than five years. There were two cancer unrelated deaths: one died of renal failure and the other died of unknown cause. The 5-year survival rate was 90.1%. In conclusion, when small peripheral pulmonary tumors are diagnosed as bronchiolo-alveolar type adenocarcinoma with minimal fibrotic foci and show non-invasive signs on intraoperative frozen section, our results suggest that limited pulmonary resection could be a curative operation.View full abstractDownload PDF (3171K) -
Futoshi Tsubokawa, Yukio Takeshima, Taijirou Sueda, Hiroo Shikata, Shi ...1998 Volume 38 Issue 2 Pages 117-122
Published: April 20, 1998
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe examined histopathological features as well as immunohistochemical features of 6 cases of solitary fibrous tumor of the pleura. Three of six patients were men and the others were women. The ages ranged from 49 to 67 and the mean was 58 years old. The resected tumors measured 1. 5-20cm (mean: 8.3cm) in the greatest dimension, and 4 cases were attached to the visceral pleura by a pedicle and 2 cases were located in the parietal pleura. Grossly, the tumor was encapsulated and the cut surface was firm, gray-white in color. Microscopically, spindle cells were arranged haphazardly in accordance with a “patternless pattern”. Immunohistochemically spindle cells expressed CD34 and vimentin, and on the contrary, keratin was negative. In each of the cases, some tumor cells expressed neurofilament, S-100 or α-SMA, which indicated differentiation to neural cell, nerve sheath cell or smooth muscle cell, and in addition, bc1-2 was strongly expressed in all cases.View full abstractDownload PDF (6163K) -
Hiroyuki Nakamura, Kousuke Kashiwabara, Hisanaga Yagyu, Fumihiro Tsuch ...1998 Volume 38 Issue 2 Pages 123-130
Published: April 20, 1998
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSGenerally, the diagnosis of bone metastasis of lung cancer is made according to results obtained through diagnostic imaging examinations including bone scintigraphy. These techniques, however, present various problems related to factors such as quantification difficulty, false positive reactions, cost, and inconvenience. Recently, new markers for bone metabolism have been developed and their application in diagnosing bone metastasis of lung cancer was studied. Compared to subjects with benign pulmonary diseases (3.7±1.1ng/ml) and those with lung cancer without bone metastasis (4.6±1.6 ng/ml), patients with lung cancer complicated by bone metastasis showed a significantly higher ICTP level (9.0±5.2ng/ml) (p<0.05). Furthermore, the ICTP level increased remarkably with progression of metastasis (p=0.012). As for the PICP level, no significant difference was recognized between the above three groups of patients, and progression of bone metastasis did not result in an increased PICP level. This indicated that PICP is not effective in making a diagnosis of bone metastasis of lung cancer or in evaluating the progression of bone metastasis. ICTP reflected bone metastasis and served as a cofactor for staging and evaluating the progression of bone metastasis. Moreover, these findings suggest that ICTP might be useful for monitoring.View full abstractDownload PDF (918K) -
Akihiko Tanaka, Tei Satou, Atsunobu Nakase1998 Volume 38 Issue 2 Pages 131-138
Published: April 20, 1998
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSLung cancers were found in five men who had received radical treatment of prior laryngeal cancer.
The histological type of the subsequent lung cancer was adenocarcinoma in one case, squamous cell carcinoma (SCC) in four cases. Since all the laryngeal cancers were SCC, the adenocarcinoma of the lung was automatically diagnosed as a second primary malignant tumor. Although laryngeal and lung cancers were moderately or well differentiated SCC histologically in four cases, the pulmonary lesions were diagnosed as second primary malignancies rather than metastatic lesions because of the successful treatment and early staging of initial laryngeal cancer.
All patients were heavy smokers, and their mean age was 73.8 years old. Three patients had two pulmonary tumors located separately in different ipsilateral lobes. These lesions were considered to be multiple primary lung cancers rather than pulmonary metastases because there was no metastasis to any intrapleural lymph nodes histologically and all cases had long survival.
Resection of pulmonary tumors was performed for all patients; bilobectomy in one case and a lobectomy combined with wedge resection or segmental excision in three cases.
One patient died of recurrent lung cancer after 41 months and four are alive after 6 to 30 months since lobectomy. Three of them are free from cancer. One patient has residual cancer of the bronchial stump in spite of radio-chemotherapy after pulmonary surgery.
In follow-up of laryngeal cancer, more attention should be paid to the possibility of a second primary lung cancer and multiple primary lung cancers because early diagnosis and aggressive treatment may prolong survival.View full abstractDownload PDF (3274K) -
Hiroyuki Saito, Akio Mizusawa, Tatsuo Ebe, Kenichi Togashi, Hiroyuki U ...1998 Volume 38 Issue 2 Pages 139-144
Published: April 20, 1998
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 49-year-old man, who had first been given a diagnosis of malignant fibrous xanthoma of the right humerus 20 years previously and undergone disarticulation of the right shoulder, was admitted to our hospital because of bloody sputum. Chest X-ray and computed tomogram scan films showed a mass lesion in the right S9, demonstrating spiculation and pleural indentation, suggesting a malignant tumor. Partial lung resection of the right S9 and S10 was carried out in September, 1994. Histopathological examination revealed massive proliferation of atypical spindle cells with foci of vague storiform pattern, identical to those of the right humerus. All immunohistochemical stainings of both bone and lung tumors were negative. These results suggested that the histopathological diagnosis of these tumors was undifferentiated sarcoma, the histopathological findings of which were the same as those of malignant fibrous histiocytoma.View full abstractDownload PDF (6407K) -
Kimito Orino, Mitsuo Kawamura, Yoshiro Sazawa, Ichiro Suzuki1998 Volume 38 Issue 2 Pages 145-148
Published: April 20, 1998
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 76-year-old woman was admitted with an abnormal chest shadow. Chest X-ray examination showed a small nodule with pleural indentation in the left lower lobe. The F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) scan showed high uptake in the tumor. The tumor was resected by video-assisted thoracoscopic surgery and diagnosed as cryptococcosis. Antimycotic agent was administered postoperatively for 12 months.
The FDG-PET scan is a useful technique for the diagnosis of peripherally located lung cancer. However, there are some false positive cases in granulomatous disease, as in this case.View full abstractDownload PDF (5472K) -
Akihiko Kitami, Takashi Suzuki, Izumi Shichi, Takeshi Kobayashi, Hiroy ...1998 Volume 38 Issue 2 Pages 149-152
Published: April 20, 1998
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA case of primary lung cancer was detected owing to a highlevel of CA19-9. An 80-year-old male who had experienced sigmoidectomy for colon cancer 10 years previously exhibited a high-level of serum CA19-9 upon outpatient examination. Abdominal examination showed no abnormal findings. Chest CT revealed a bulla with a thickened wall in the left S6. Histological examination of a lung specimen obtained by TBLB showed adenocarcinoma. We performed a left lower lobectomy.
Histological examination of a lung specimen obtained at operation revealed a welldifferentiated papillary-type adenocarcinoma. Immunohistochemically, the tumor cells stained positively for CA19-9. We ultimately diagnosed a primary lung cancer producing CA19-9.View full abstractDownload PDF (3111K) -
Toshinori Hashizume, Keiichi Kikuchi, Masanori Yasuda1998 Volume 38 Issue 2 Pages 153-157
Published: April 20, 1998
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 69-year-old man, with a past history of artificial pneumothorax for pulmonary tuberculosis at the age of 24 was referred to our hospital for examination and treatment of left chest pain and swelling of the left chest wall. Serum NSE and LDH were high, and the computed tomography image of the chest showed a tumor mass from the wall of a chronic pyothorax spreading to subcutaneous tissue. Surgical biopsy of the tumor revealed non-Hodgkin's lymphoma (diffuse large cell, T-cell type). Epstein-Barr virus was detected in the lymphoma cells by in situ hybridization. Combination chemotherapy with CHOP, EPIC and CEP was performed but the patient died 5 months later after chemotherapy.View full abstractDownload PDF (4974K) -
Yoshiki Demura, Kouhei Siozaki, Masanori Nakanishi, Shingo Ameshima, T ...1998 Volume 38 Issue 2 Pages 159-165
Published: April 20, 1998
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 68-year-old man was admitted to our hospital with edema of the bilateral lower extremities and multiple cervical and mediastinal lymphadenopathy. Histological examination of the cervical lymph node biopsy specimen revealed small cell carcinoma. Through systemic examination, liver and adrenal metastasis was diagnosed with no other suspected primary lesion except in the mediastinum. We diagnosed that he had an extensive case of small cell lung cancer with acute Budd-Chiari syndrome due to the obstruction of the inferior vena cava and hepatic veins by the liver, adrenal metastasis and tumor thrombus. Progressive edema of the lower limbs, venous dilatation in the abdominal wall and hepatomegaly were noted. Chemotherapy brought temporary relief, but he died 6 months after the onset because acute Budd-Chiari syndrome recurred. This patient was a rare example of Budd-Chiari syndrome complicated with lung carcinoma and small cell carcinoma.View full abstractDownload PDF (10692K) -
Shuhei Inoue, Noriaki Tezuka, Satoru Sawai, Takaaki Konishi, Keiichi K ...1998 Volume 38 Issue 2 Pages 167-170
Published: April 20, 1998
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThree patients (two men aged 58 and 56 and a woman aged 33) with previous pneumonectomy for lung cancer underwent an additional resection because of a second primary lung cancer (both men) or pulmonary metastasis (the woman) in the remaining lung. The second pulmonary resection was wedge excision, and in one case, a third resection, segmentectomy was performed. The primary lung cancer site, histology, stage, interval between the first and second operation, and the histology of the second cancer were as follows: left, left, right; squamous cell carcinoma, large cell carcinoma, well differentiated fetal adenocarcinoma WDFA; pT2NOMO, pT2N2M0, pT2N1M0; 81-, 98-, 24-months; large cell carcinoma, adenocarcinoma and WDFA. All patients are now living after the second operation: one has no evidence of disease (42 months), one has pleuritis carcinomatosa (12 months), and the other had segmentectomy 13 months after the second operation and is now disease free (17 months).
It is evident that pulmonary resection after pneumonectomy is feasible with a low operation mortality, and that resection of these secondary tumors can result in prolonged, worthwhile survival.View full abstractDownload PDF (434K) -
Eishin Hoshi, Katsuhiko Aoyama, Katsumi Murai, Noboru Takayanagi, Tosh ...1998 Volume 38 Issue 2 Pages 171-175
Published: April 20, 1998
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 47-year-old woman who had complained of severe cough and dyspnea was admitted for evaluation of an abnormal shadow seen in the left hilum on chest x-ray. Chest CT and MRI scans revealed a 5.8×4.5cm tumor in the carina involving the trachea and left main bronchus. Bronchofiberscopy revealed a submucosal tumor that obstructed the orifice of the left main bronchus. We could not obtain a definitive diagnosis by tumor biopsy, but we suspected a malignant tumor because of the progressive symptoms. We performed a left sleeve pneumonectomy and the pathological diagnosis was benign schwannoma.View full abstractDownload PDF (6736K) -
Ryohei Yamashita, Tetsuyuki Sumohara, Kenichi Ietsugu, Mitsuyo Kosugi1998 Volume 38 Issue 2 Pages 177-181
Published: April 20, 1998
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 68-year-old man underwent right upper lobectomy for squamous cell carcinoma of the lung in December 1995. The Pathological stage was TIMM0, and the postoperative course was uneventful. In August 1996, a hard subcutaneous mass 4cm in diameter was detected in the right thoracodorsal region. Chest CT scan showed a well enhanced mass in the right latissimus dorsi muscle. Needle aspiration cytology of the mass revealed malignant cells and the tumor was resected. Histologically, the tumor was composed of infiltrating moderately differentiated squamous cell carcinoma similar to the previously resected lung cancer. Chemotherapy by cisplatin and 5FU was given twice postoperatively. As of September 1997, the patient is alive with no evidence of tumor recurrence.
Skeletal muscle metastasis from lung cancer is extremely rare. In Japan only nine cases have been reported and the outcome of those cases was very poor. Therefore careful follow-up is necessary.View full abstractDownload PDF (4329K) -
1998 Volume 38 Issue 2 Pages 182-201
Published: April 20, 1998
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (3031K)
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