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Volume 18 (1978)
- Issue 4 Pages 341-
- Issue 3 Pages 231-
- Issue 2 Pages 101-
- Issue 1 Pages 1-
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Volume 18, Issue 1
Displaying 1-11 of 11 articles from this issue
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H. Homma, M. Tamura, K. Watanabe, K. Sagawa, K. Inatomi, S. Kira, S. I ...1978 Volume 18 Issue 1 Pages 1-5
Published: March 05, 1978
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSThe purpose of this study is to evaluate the adequacy of roentgenologycally determined stages in patients with pulmonary cancer. The clinical stage classification of the Japan Lung Cancer Society was used. And pre and post thoracotomy stages were compared in 108 cases.
The results revealed that only 58 cases among 108 cases (53.7%) were diagnosed adequately. The cause of misjudges mostly derived from the difficulty to differentiate whether lymph nodes in the hilum and in the mediastinum were involved or not.View full abstractDownload PDF (469K) -
Findings of Roentgenogram and Perfusion Scintigram in 17 CasesTadashige Fujii, Hisakata Kanai, Shinici Ookubo, Toshio Kobayashi, Ich ...1978 Volume 18 Issue 1 Pages 7-19
Published: March 05, 1978
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSFindings of chest roentgenogram and perfusion scintigram were studied in 17 cases of primary pulmonary carcinoma with pleural indentation. Histologically, 16 cases were adenocarcinoma and one was alveolar cell carcinoma. The pleural indentation was demonstrated in 15 cases such as streaky or strand shadow connected with triangular shadow at the chest wall, and indrawing of interlobar pleura toward tumorous shadow was shown in 6 cases. In 10 cases, contraction of the peripheral bronchi around tumor was demonstrated bronchographically, and that of pulmonary vascular marking was shown in 8 cases, too. The perfusion scintigraphy was carried out on 16 cases. In 11 cases, area of decreased radioactivity was more extended than that expected from the tumorous shadow on chest x-ray film. The abnormal findings of perfusion scintigram were discussed in relation to the pleural indentation, the contraction of the peripheral bronchi and that of the pulmonary arteries.View full abstractDownload PDF (10183K) -
Kinya Sawada, [in Japanese], [in Japanese], [in Japanese], [in Japanes ...1978 Volume 18 Issue 1 Pages 21-30
Published: March 05, 1978
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSIn 1958, Nash and Stout called attention to a type of primary lung cancer comprised principally of giant cells and variable focuses of anaplastic frequently mesenchymal-like components resembling rhabdomyosarcoma or osteosarcoma.
Giant cell carcinoma of the lung occurred at a younger age, exhibited widespread metastases, and pursed a more rapid, fulminant course than histological variants. Its lower resectability rate compared to other lung carcinomas.
We studied materials before radiation and chemotherapy in five cases of giant cell carcinoma of the lung obtained by bronchoscopic brushing method and transthoracic aspiration. These materials were informative for study of fresh cancer cells.
Chest x-ray findings in all cases a nodular shadow.
Morphological features were studied with stain methods such as Pap., Giemsa, PAS, Mucicarmin, and Alcianblue reaction.
Multinucleated and uninucleated bizzarre giant cells showed to phagocytize neutrophils, and debris and uneven dispersed distribution or a pooly cohesive groups but never in tight clusters. Occasionally cancer cells were found in necrotic substances. The cancer cells were round or smooth but showed lobulation, budding, indentation and constriction, and chromatin was coarsely or fine and rich. The nucleoli were round and small.
In differential diagnosis, we studied on similarity and difference with epidermoid carcinoma, choriocarcinoma, rhabdomyosacoma, osteosarcoma, Langhans's giant cell and histiocyte.View full abstractDownload PDF (4123K) -
T. Kimoto, H. Nakata, M. Ohno, [in Japanese], [in Japanese]1978 Volume 18 Issue 1 Pages 31-37
Published: March 05, 1978
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSWe reviewed 335 cases of lung cancer and evaluated roentgenological findings of bone metastasis. Forty four (13%) of 335 cases had bone metastasis either at admission or during the course of the disease. Forty cases (90%) were osteolytic on roentgeno grams. Four cases (10%) showed sclerotic lesions, 2 of which were adenocarcinomas, and the other 2 were anaplastic carcinomas other than small cell type. Only one case of sclerotic metastasis due to aderocarcinoma had the appearance of bone carcinosis. The majority of the bone metastasis were located in the red bone-marrow regions. The metastasis to the peripheral bone was seen only in 2 cases. Clinically, 70% of the cases with bone metastasis complained of pain related to the site of metastasis.View full abstractDownload PDF (3450K) -
Toyohiko Morita1978 Volume 18 Issue 1 Pages 39-50
Published: March 05, 1978
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSSeventy-six cases, received lymph node biopsy, out of consecutive 409 lung cancer autopsy cases from 1958 to 1975 at the Department of Pathology, University of Tokyo, were studied clinicopathologically. Lymph node biopsy is losing its diagnostic value in lung cancer with the peak of 30% of 1964 to 1966, whereas bronchial fiberscope biopsy is gradually increasing since 1963 and now almost the same incidence, i. e. 18%, as lymph node biopsy. Difficulty in histological diagnosis and variety of lung cancer pattern at both biopsy and autopsy are discussed. The average clinical course after the confirmation of lung cancer by lymph node biopsy was 4.3 months for the entire cases, 6.8 months in squamous cell ca., 5.8 months in small cell anaplastic ca., and 2.7 months in adenoca. cases. There were 2 cases, alive more than 12 months after the biopsy, a case of small cell anaplastic ca. survived 29 months and a case of sq. cell ca. survived 42 months, both received successful radiotherapy.
As for histological findings of lymph nodes and prognosis after the biopsy, preservation of lymph node structure and vascular permeation by cancer cells are not contributory in lymph node metastases of lung cancer more distant than the supraclavicular region. As indicators of immunological activity of patients, paracortical lymphoid hyperplasia, germinal center activity and sinus histiocytosis are all beneficial findings for better prognosis which is statistically significant.View full abstractDownload PDF (1363K) -
Nagahiro SAIJO, Yutaka NISHIWAKI, Ichiro KAWASE, Toshiji KOBAYASHI, Ak ...1978 Volume 18 Issue 1 Pages 51-57
Published: March 05, 1978
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSThe incidence of pleural effusions and tumor cells in pleural effusions were examined in 287 primary lung cancers with three histological types such as adeno-carcinoma, small cell carcinoma and squamous cell carcinoma. The Effects of systemic chemotherapy mainly with Mitomycin C plus lysosome labilizers and thoracenthesis or tube thoracostomy with local instillation of anti-cancer agents mainly with Mitomycin C or Adriamycin were also evaluated for the volumes of pleural effusions accumulated and for tumor cells in pleural effusions. In 147 cases of adenocarcinoma, most of which arise in the peripheral area of the lung and grows closely related to visceral pleura, 55 cases (37.4%) developed pleural effusions and 52 out of 54 cases (96.3%) were cytologically positive. In 73 cases with pleural effusions, the range of survival was 1-35 months and the median survival was 8.0 months from the beginning of treatments. In cases whose pleural effusions were reduced in volumes, the median survival prolonged to 10.2 months. In the majority of small cell carcinomas and squamous cell carcinomas, pleural effusions were effectively controlled by systemic chemotherapy alone, however, in adenocarcinomas, pleural effusions were not palliated by systemic chmotherapy alone unless thoracenthesis or tube thoracostomy with local instillation of anti-cancer agents were utilized. It can be concluded that active treatment utilizing anti-cancer agents systemically and/or locally for the malignant pleural effusions results in the prolongation of the survival of patients.View full abstractDownload PDF (688K) -
Yasumasa MONDEN, Akira MASAOKA, Hideo NISHIKAWA, Masazumi MAEDA, Kazuy ...1978 Volume 18 Issue 1 Pages 59-68
Published: March 05, 1978
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSThe relationship between clinical tests and the general condition (Performance Status) was studied in patients with lung cancer. N/L ratio, serum albumin and erythrocyte sedimentation rate (ESR) were correlated to Performance Status. Based on these three parameters, we established a criteria, that is, “Status Index” as a parameter of the general condition.
This “Status Index” was well reflected in Performance Status.View full abstractDownload PDF (970K) -
Youshin Mizukami, Yuji Kimula, Kozui Kida, Youko Murai, Yasunobu Fukus ...1978 Volume 18 Issue 1 Pages 69-74
Published: March 05, 1978
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSA 73 years old man was admitted for left lateral chest pain on March 14, 1974. Though he had received a double course of drug medication against lung tuberculosis in 1951, its exacerbation complicated left empyema in 1965. In September, 1973, he felt pain in the left lateral chest, and it became worse with bloody sputum and noticed a swelling on the lateral chest wall in Febrary, 1974. On admission, a chest X-ray examination showed a first-sized tumor in a posterior portion of the left lung involving the chest wall with 4th and 5th ribs destruction. General condition was gradually deteriorated against radiation therapy, he died of complicated pneumonia on March 30, 1975. Autopsy revealed a solid tumor, 10×5×9cm in size, arisen possibly from the chest wall of the empyema of the left thoracic cavity. The tumor invaded continuously into the chest wall and eroded 3rd. 4th, 5th and 6th ribs. The tumor compressed the left lung and microscopic infiltration in the subpleural lung parenchyme was detected in the superior segment of the corresponding lower lobe. The tumor consist of well-differentiated epidermoid carcinoma which showed significant keratini zation. Since no fistulation between the empyema cavity and either bronchus or skin, the tumor was interpreted as the primary malignancy originated from the cavity wall.View full abstractDownload PDF (5010K) -
Keigo Takagi, Yukio Shimosato, Toru Kameya, Takeshi Yoneyama, Keiichi ...1978 Volume 18 Issue 1 Pages 75-80
Published: March 05, 1978
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSA 53-year-old female underwent left upper lobectomy for bronchiolo-alveolar carcinoma of 1.5 cm in diameter. This tumor was associated with epithelioid cell granulomas of unknown etiology, which were found in the central zone of fibrosis andadmixed with proliferating tumor. From the clinical course, laboratory data and pathological findings, we concluded that epithelioid cell granulomas were saroidlike lesion associated with bronchiolo-alveolar carcinoma, although the possibility of specific infection such as “tuberculosis” could not be denied.
Developmental process of central fibrosis in the primary lung cancer was also discussed briefly.View full abstractDownload PDF (3678K) -
1978 Volume 18 Issue 1 Pages 81-82
Published: March 05, 1978
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSDownload PDF (165K) -
1978 Volume 18 Issue 1 Pages 83-99
Published: March 05, 1978
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSDownload PDF (2400K)
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