In order to increase the accuracy of diagnosis of pulmonary carcinoma, to hypothesize the prognosis and to be able to design an early plan of treatment, characteristic roentgenographic findings on plain film and tomogram of the chest and bronchogram were studied in relation to the histopathologic findings.
121 recent cases of bronchogenic carcinoma, including early and advanced stages, were inspected histopathologically at operation, autopsy or bronchoscopic punch biopsy.
On tomogram and bronchograms of pulmonary carcinoma, more than 17 distinguishable X-ray signs which show correlation with histopathologic classification were selected. The characteristic features of each histologic type were determined.
The X-rays of 100 cases of pulmonary carcinoma, confirmed after operation, autopsy or biopsy, were observed carefully with regard to characteristic features of the histologic types. Of the 100 cases studied, 84.3% of squamous cell carcinoma, 81.5% of adenocarcinoma, 53.9% of large cell carcinoma and 80.0% of small cell carcinoma were accurately disgnosed. The overall accuracy of histopathological diagnosis by X-ray inspection was 78%.
In the cases of peripheral adenocarcinoma and squamous cell carcinoma, introduction of linear discriminant analysis by computer in the process of synthetic judgment of the characteristic roentgen findings was employed to confirm the possibility of histopathological diagnosis by X-ray features. The result was that an average of 89% of pathological diagnosis coincided with the computer diagnosis in the testing group.

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The purpose of this paper is to study whether there is a trend toward histologic type specific structure of the vessels in lung cancer tissue or not by means of selective bronchial angiography.(B. A. G.) Special attention was paid to study the detailed structure of bronchial arterial nets with the aid of macroangiography and microangiography in the resected lung combined with B. A. G., because angiographic findings of the resected lung were very usefull for analisis of B. A. G.
122 cases of lung cancer, practiced with B. A. G. and 79 cases out of them were studied with macroangiogram and microangiogram.
Close relation between histologic type of the tumor tissue and the angiographic structure of tumor vessels, which was demonstrated in B. A. G.(Table 3) and angiogram of the resected lung, especially the fine structure of the vascular nets, was observed.
Most of histologic type of lung cancer were determined by reading carefully the various angiographic patterns which depend upon the characters of cancer tissue, such as, mode of bronchial and lung parenchimal invasion, site of origin, existence of necrosis or scar and so on. To decide the histologic type, the most important facters which appeared in angiogram were the characters of stroma of cancer tissue and behaviour of cancer to the bronchus wall.

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Lung cancer was induced in nine out of ten rabbits by weekly application of 50mg. 20-methlcholanthrene (MC) to the right peripheral bronchi using rigid bronchoscope for rabbit. Twenty-MC was dissolved in 1.5 ml. sterilized water and was administered during the period of 11 months to one year and three months. Autopsy was curried out when a rabbit developed serious illness. The induced tumors were nodular in seven, infiltrative with ill-defined border in one and multi nodular in one. The metastasis were found in the lymph nodes of the tracheo-bronchial and paratracheal region in all cases, and in the chest wall or kidney in some cases. Histologic examination revealed squamous cell carcinoma in six and adenocarcinoma in three.

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On high incidence of lung cancer in the workers of the chromate industry that was located near Sapporo city was already reported.
Further studies of these patients, epidemiologically and pathologically, revealed following distinct points.
1) The latent period of occurence of bronchogenic carcinoma, i. e., from beginning of chromate exposure to detection of lung cancer, measured 21.9 years on average, which was ca. 7 years longer than the reported average.
2) Histological examination of the lung revealed squamous cell carcinoma in 4 cases and oat cell carcinoma in 3 cases. No cases of adeno carcinoma were detected.
3) Primary lesions of bronchogenic carcinoma were at the left upper bronchus in one case, at the left lower lobe bronchus in remaining 6 cases. No peripheral lesion was not seen.

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Forty-seven patients with cerebral metastasis from lung cancer seen during twelve-year period (1959 to 1971) were evaluated. Forty patients (85%) had various symptoms and signs due to cerebral metastasis, 7 patients (15%) without symptoms revealed to have had metastasis at autopsies.
Incidence of cerebral metastasis was predominant in younger patients and higher in females than in males. Small cell carcinoma, adenocarcinoma and large cell carcinoma exhibited greater tendencies (about 25% of each histological type) to metastasize to the brain than epidermoid carcinoma (15.2%).
As to the cause of death of lung cancer, 13.7% of all patients, therefore 60-70% of patients with cerebral metastasis died of the event. Twelve patients had irradiation to the whole brain by 60 Cobalt teletherapy unit. Half of them could not complete treatment due to progressive general conditions.
Four patients out of 6, who were irradiated with 3, 000 rad or more had good improvement. Policy and result of radiotherapy of cerebral metastasis from lung cancer in the literature were reviewed and discussed.

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