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Volume 26, Issue 7
Displaying 1-11 of 11 articles from this issue
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Tasuku Nakada, Hirotoshi Sato, Yasuki Saito1986 Volume 26 Issue 7 Pages 727-736
Published: December 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSEighty-two primary and 6 metastatic lung cancers were detected during 3 years from 1982 to 1984 by X-ray examinations in a total of 363, 320 participants. Sputum cytology in the high-risk group (above 50 years of age with cigarette index above 600) resulted in detection of 67 malignant tumors which included 62 primary lung cancers. Of the lung cancers detected by sputum cytology 82.3% were radiographically occult lung cancers. Theannual ratio of detection was 45/100, 000 in the first year. It decreased to 38/100, 000 in the second year and to 15/100, 000 in the third year. Resection was performed in 63.6%, 76.1% and 80% in the first, second and third years respectively. On the average, 57% of the resections were early lung cancers. Especially of 51 cases detected by sputum cytology, 45 underwent resection, of which 40 (89%) were early lung cancers.View full abstractDownload PDF (1001K) -
Hirotoshi Dosaka1986 Volume 26 Issue 7 Pages 737-743
Published: December 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe inducibility of sister chromatid exchanges (SCEs) by benzo [a] pyrene (BP) was studied in cultured peripheral blood lymphocytes of untreated lung cancer patients and healthy individuals with high or low risk for developing cancer, each of the 3 groups consisting of 15, 11, 14 subjects, respectively. We defined those who had 4 or more family members with malignant neoplasia within the third-degree relatives as members of the high risk group, while those who had no such familial history of neoplasia were defined as members of the low risk group. The lung cancer patients came from neither group. The spontaneous SCE frequency in lymphocytes of lung cancer patients was signifcantly higher than that of low risk individuals. The SCE yeilds by BP in the lymphocytes from lung cancer patients and members of the high risk group were significantly greater than members of the low risk group. The present findings suggest that members of high risk group may be more susceptible to BP than members of low risk group.View full abstractDownload PDF (831K) -
Shinya Kusachi, Masumi Kurashige, Hideaki Suzuki, Yasumasa Taguchi, Mi ...1986 Volume 26 Issue 7 Pages 745-751
Published: December 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA total of 155 cases of adenoid cystic carcinoma have been reported in Japan. We selected 34 cases for which detailed pathological findings were available and classified them into 4 types as follows.
Type I (semipedunculated type): The tumor grows in a bulbous intralumenal form, covered with mucosal membrane, and with minimum invasion to the wall.
Type II (intra-and extra-lumenal type): The tumor grows into the lumen, covered with mucosa, as a wide-based elevated lesion and infiltrates beyond the wall.
Type III (expansive, infiltrating type): The tumor grows expansively, both along and around the airway wall, and both into the lumen and beyond the airway wall.
Type IV (peripheral type): Tumor originates from a peripheral bronchus. There are no findings of tumor in the visual field of the bronchofiberscope.View full abstractDownload PDF (2577K) -
Yasuo Saito, Shuichi Chohtoh, Hiroshi Nishijima, Akihiko Kobayashi, Ji ...1986 Volume 26 Issue 7 Pages 753-762
Published: December 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTreatment results of 49 patients (25, limited disease, LD, 24, extensive disease, ED) with small cell lung cancer were retrospectively analyzed. Fifteen patients received chemotherapy with Cyclophosphamide (CPM) and Vincristine (VCR) following thoracic radiotherapy (RT). Twenty-two patients were given induction chemotherapy with CPM, Adriamycin (ADM), and VCR and were followed by thoracic RT. Other chemotherapy consisted of CPM, VCR, Methotrexate, and ADM in 2 patients, 5-FU, CPM, Mitomycin C, and Toyomycin in 1 patient. The remaining 9 patients (2, LD, 7, ED) were treated with RT alone.
The response rate was 80%(64% CR; 16% PR) for LD patients and 33%(4% CR; 29% PR) for ED patients (P<0.001). The three-year survival (Kaplan-Meier's product) of all patients was 14%, with a median survival time (MST) of 8 months. For patients with LD, the 3-year survival was 27%(MST 15 months). Survival of patients with ED was 14% at 1 year, 0% at 2 year (MST 5.5 months). The difference between these figures was statistically significant (P<0.0003). The 3-year survival and relapse-free survival for complete responders with LD were 43%(MST 21 months) and 36%(median CR duration, 11.5 months) respectively. Six of 16 complete responders with LD are alive and well at over 2 years.
Local recurrence rate of the complete responders with LD was 28.8%. None of the 7 complete responders given more than 48 Gy relapsed within the radiation field.
We believe that the addition of thoracic RT to patients with LD is necessary for the control of the primary tumors and for long-term disease-free survival.View full abstractDownload PDF (1031K) -
Reiko Inoue, Tomoo Ohtsuka, Kimio Shimura, Takeshi Hirayama1986 Volume 26 Issue 7 Pages 763-767
Published: December 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA case-control study composed of 83 cases of lung cancer (87% of total deaths due to lung cancer) and 166 cases of sex-age-year death matched control, conducted in Miura City, Kanagawa, Japan revealed a significantly higher lung cancer risk in heavy smokers (r.r. for 40 or more cigarettes daily, 4.8) among those who started smoking in their teens (r.r. 6.9) and in fishermen with the various occupations (r.r. 2.06). Fishermen smoking 40 or more cigarettes daily showed the highest risk (r.r. 8.8) suggesting the combined effect of smoking and occupation-specific risk factor (s). Further, non-smoking wives were observed to have a significantly higher risk of lung cancer with the increase in the amount of smoking of their husbands, suggesting the influence of passive smoking.View full abstractDownload PDF (499K) -
Toshiki Matsubara, Iwao Kinoshita, Ken Nakagawa, Nagaharu Tsuchiya1986 Volume 26 Issue 7 Pages 769-777
Published: December 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe size of the lymph node image is an important factor in computed tomographic evaluation of mediastinal lymph node involvement. CT images were retrospectively reviewed in 188 patients with primary lung cancer who underwent pulmonary resection. Comparing the lymph node size in CT images with the result of the histological confirmation, the sensitivity and the specificity were calculated as the functions of the threshold for the diagnosis. The calculated curves of the sensitivity and the specificity showed that the diagnostic capability of CT scan differs, depending on the lymph node location and the histological type of lung cancer. The most adequate threshold for the diagnosis varies according to the clinical purpose of CT diagnosis. Methods for obtaining the most adequate threshold were investigated, and on the basis of the actual sensitivity and specificity curves, it was attempted to calculate the most adequate thresholds for certain determined clinical purposes.View full abstractDownload PDF (3441K) -
Yasuki Fukuda, Masayuki Nakata, Shuuichi Yoneda, Yukio Noguchi, Takesh ...1986 Volume 26 Issue 7 Pages 779-788
Published: December 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo analyse the clinical feature of multiple primary cancer associated with primary lung cancer, 986 autopsied malignant cases were studied. Eighty-one cases were multiple primary cancer cases. Twenty-eight out of the 206 lung cancer cases (13.6%) were combined with another primary cancer, and this constituted 34.6% of 81 multiple primary cancers. They consisted of 10 squamous cell carcinomas, 11 adenocarcinomas, 5 small cell carcinomas and 5 large cell carcinomas (including 3 multiple lung cancers), and the incidence in each histological type was from 13 to 16%.
Eight cases of 15 overt second cancers had an abnormal shadow on chest X ray films, and 7 out of 8 were the second primary lung cancers. However they were diagnosed as tuberculomas in 2, solitary metastatic lung cancer in 1, multiple metastatic lung cancers in 3 and primary lung cancer in 1.
Median survival time (MST) of 25 cases who died of cancer was 8 months. There was statistical significance (p<0.0178) between the survival curve of preceeding lung cancer cases (MST-7 months) and that of succeeding lung cancer cases (MST-26 months). The median survival time after the recognition of the second lung cancer in the succeeding lung cancer cases (MST =4 months) was shorter than that of the preceeding lung cancer cases (MST-7 months) with statistical significance (p<0.0004).
In the clinical examination of malignant diseases, more attention should be paid to the possibility of second primary cancer because earlier diagnosis and aggresive treatment may prolong the survival time.View full abstractDownload PDF (2834K) -
Application of Radiotherapy to AdenocarcinomaYoshihiro Saito, Nobuaki Nakajima, Yasunobu Maehara, Kazushige Hayakaw ...1986 Volume 26 Issue 7 Pages 789-794
Published: December 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAnalysis of 137 patients with adenocarcinoma of the lung who were mainly treated by radiotherapy was performed. The 5-year survival rate was 19% in stage I (15) and 20% in stage II (14). Survival rate by histologic subtype in stage I or II was better in well differentiated cases than in poorly differentiated cases. Five 5-year survivors were all well differentiated adenocarcinoma cases and four were in stage I or II, one was in stage IV. From these results it was considered that in stage I or II well differentiated adenocarcinoma cases radical radiotherapy can be indicated.View full abstractDownload PDF (650K) -
Mitsutaka Kadokura, Masanobu Hirata, Takashi Arai, Keizo Inagaki, Jun ...1986 Volume 26 Issue 7 Pages 795-801
Published: December 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTwo surgical cases of non-Hodgkin's lymphoma arising from the empyema wall were reported.
Case 1: A 54 year-old female, who had been treated with artificial pneumothorax for pulmonary tuberculosis 40 years ago, suffered from empyema with a bronchopleural fistula. She was treated with left pleuropneumonectomy. It was found that the empyema and non-Hodgkin's lymphoma (diffuse, large cell type) originated from the pleura, then chemotherapy with Cyclophosphamide, Vincristine, Procarbazine and Prednisolone was carried out. The patient is doing well at 21 months postoperatively.
Case 2: A 53 year-old male, who had been treated with artificial pneumothorax 33 years ago, was admitted with fever and a large tumor shadow on chest X-ray film. He was treated with right pleuropneumonectomy. The resected specimen showed a large (12×8×8cm) tumor contiguous to a small empyema space. Histologically, it was non-Hodgkin's lymphoma (diffuse, pleomorphic type) originating from the pleura. Radiotherapy with a total of 45Gy was followed by chemotherapy with Bleomycin, Cyclophosphamide, 6-MP and Prednisolone. The patient is doing well at 6 months postoperatively.View full abstractDownload PDF (7227K) -
Nobuyuki Mitani, [in Japanese], [in Japanese], [in Japanese], [in Japa ...1986 Volume 26 Issue 7 Pages 803-808
Published: December 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe patient was a 61 year-old male.First, his chest radiogram revealed a thin-walled cystic lesion containing a mass shadow in the cavity.Four months later, the cyst wall was irregularly thickened.Pulmonary aspergillosis of the fungus ball type was suspected from the X-ray findings, but the histological examination from the resected specimen revealed a combination of squamous cell carcinoma and aspergillosis in a cavitary space in the right upper lobe S2. Concerning the mechanism of combined occurrence, it was assumed that the carcinoma of the proximal bronchus developed cystic changes in the distal pulmonary tissue through a check-valve mechanism, and extended along the cyst wall, and then an aspergillar infection occurred secondarily.View full abstractDownload PDF (5871K) -
1986 Volume 26 Issue 7 Pages 809-822
Published: December 25, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (2152K)
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