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Volume 24 (1984)
- Issue 6 Pages 691-
- Issue 5 Pages 469-
- Issue 4 Pages 347-
- Issue 3 Pages 229-
- Issue 2 Pages 117-
- Issue 1 Pages 1-
Volume 24, Issue 6
Displaying 1-11 of 11 articles from this issue
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Hikotaro Komatsu, Ryozo Yoneda, Takashi Ishihara1984 Volume 24 Issue 6 Pages 691-700
Published: December 30, 1984
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFive autopsy cases of bronchiolo-alveolar cell carcinoma with diffuse shadows in bilateral lung fields and abundant mucin like contents in tumor cells were studied. These 5 cases were classified into 2 groups according to cytologic morphology.
Group 1: The shape of tumor cells is nearly cubic with abundant mucin-like contents. The N/C ratio is low and the locus of the nucleus is found at the base.
Group 2: The tumor cells are columnal and the N/C ratio is higher than that of group 1. The locus of the nucleus is located more often in the center of tumor cell compared with group 1.
The above 2 groups revealed different X-ray findings. Group 1 showed a ground glass-like shadow in the early stage with the shadow gradually increasing in density with changes to pneumonia or indistinct shadow.
Group 2 showed patchy shadows, most of which gradually fused with each other and subsequently the center of the shadow crumbled and changed to a honeycomb-lung like shadow. In both groups, there were cases whose lung volume decreased gradually, followed by the spread of the lesions. Since both groups had no lymph node metastasis, extrathoratic metastasis or invasion into the blood vessels, the type of spread was considered to be basically transbronchial.View full abstractDownload PDF (14804K) -
Akira Yamanaka, Jiro Tamada, Motohiko Ito, Takashi Teramatsu, Yoshio O ...1984 Volume 24 Issue 6 Pages 701-711
Published: December 30, 1984
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSpecimens of various subtypes of adenocarcinomas (81 cases) as well as other histological types (48 cases) were studied immunohistochemically, using PAP methods, for lysozyme, lactoferrin, and secretory component (SC), and histochemically for sialomucin.
In normal human bronchial tissues, lysozyme and lactoferrin have been demonstrated to be produced in the serous cell of the bronchial gland, and SC in both the bronchial gland and surface epithelium.
These proteins were also demonstrated in malignantly transformed cells. Lysozyme and lactoferrin were found in SC-positive cancer cells and SC was found in sialomucinpositive cells. These can also be observed in normal tissues, and it indicates their reliability as markers in studying the histogenesis of pulmonary adenocarcinoma.
These proteins were found in adenocarcinoma and bronchial gland tumors, but not in large cell carcinoma nor squamous cell carcinoma. Their production was observed most frequently in cribriform adenocarcinoma (9/12) and in mucoepidermoid carcinoma (2/4). As for the other subtypes, less protein production was seen in the bronchiolo-alveolar type (1/6) than in the tubular or papillary type of adenocarcinoma (20/63). There was no difference of SC production in tubular and papillary type adenocarcinoma.
These findings suggest that adenocarcinoma originates in the exocrine cell of the bronchial epithelium, and that cribriform adenocarcinoma originates in the bronchial gland. Both tubular and papillary adenocarcinoma seem to have the same cellular origin.View full abstractDownload PDF (6148K) -
Chojiro Yamashita, Noriaki Tsubota, Koichi Yoshikawa, Tomio Kono, Kazu ...1984 Volume 24 Issue 6 Pages 713-719
Published: December 30, 1984
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFrom 1973 through 1982, a total of 249 patients with lung cancer were operated on and 26 (10.6%) were diagnosed as large cell carcinoma histologically.
The 5-year survival rate of large cell carcinoma was 50% in stage I, but there were no patients who survived more than 3 years in stages III and IV. The relation between survival rate and histologic features was discussed.
Most large cell carcinomas which showed invasive growth, frequent appearance of giant cells and vascular invasion were operated on in advanced stages, and it was concluded that these three histological features should be considered as factors indicating poor prognosis.View full abstractDownload PDF (3650K) -
Koichiro Morita, Tatsuro Oda, Hitoshi Mohri1984 Volume 24 Issue 6 Pages 721-726
Published: December 30, 1984
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSerum concentrations of α2 HS-glycoprotein, ceruloplasmin, α1-acidglycoprotein, α1-antitrypsin, haptoglobin and α2-macroglobulin were measured at approximately 2 or 3 month intervals in 19 patients with lung cancer following lobectomy and dissection of regional lymph nodes. The correlations between serum concentrations of glycoprotein and stage and prognosis were examined. The serum level of al -acid glycoprotein was more decreased in the pN2 group than in the pN1 group. The prognosis of the cases in which serum levels of α2 HS-glycoprotein were higher before surgery than after, was good compared to those of other cases.View full abstractDownload PDF (3079K) -
Yasunobu Maehara, Nobuaki Nakajima, Kazushige Hayakawa, Yoshihiro Sait ...1984 Volume 24 Issue 6 Pages 727-733
Published: December 30, 1984
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDuring the period from April 1959 to December 1982, 178 cases above the age of 70 with primary lung cancer were treated mainly with radiotherapy. The survival rate for cases of squamous cell carcinoma was higher than those of other histological types of lung cancer.
Since January 1976, our radiotherapy strategy has changed. The treatment approach was planned on the basis of the individual case in respect to the tumor-host relationship, the size, extent and nature of the lesion with reference to previous results.
The 5-year relative survival rate of squamous cell carcinoma in 72 cases improved to 15%. The 5-year relative survival rate of 23 cases of Stage I or II squamous cell carcinoma treated by radiotherapy was 50%. Radiotherapy can therefore be considered to be a suitable treatment modality for primary lung cancer in cases aged over 70.View full abstractDownload PDF (691K) -
Kinya Sawada, Seigo Fukuma, Yasuo Seki, Itsuro Ishida, Kimito Matsumur ...1984 Volume 24 Issue 6 Pages 735-742
Published: December 30, 1984
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAmong 649 patients with lung cancer during the past 10 years, 57 (8.8%) were proved to have brain metastases. From a histological standpoint, brain matastases were most prevalent in large cell carcinoma, followed by small cell carcinoma, adenocarcinoma and squamous cell carcinoma, in decreasing frequency.
The initial symptoms and signs varied, and included headache, neurologic defects and so on. The interval between the diagnosis of lung cancer and the appearance of brain metastases was longer in adenocarcinoma than in other histologic types.
The manifestation of brain metastases before the diagnosis of lung cancer was established was noted with greater frequency in adenocarcinoma than in other hisologic types. Solitary and multiple brain metastases were shown by brain CT to occur in equal numbers.
Furthermore, characteristics most commonly seen in adenocarcinoma by brain CT were as follows:
1) Solitary lesion, 2) Isodensity on plain CT, 3) Location in frontal lobe, 4) Solid in form, 5) Severe edema surrounding the metastatic tumor.
With regard to the management of brain metastases, most patients were treated with combined radiation-chemotherapy. Nevertheless, thoracotomy in conjunction with craniotomy was likely to give the most benefit in terms of survival prolongation. Autopsy studies confirmed metastases as the cause of death in more than half of patients with brain metastases.View full abstractDownload PDF (635K) -
Ryuichi Higashiguchi, Hitoshi Katada, Michiko Ueno, Nobuhiro Narita, R ...1984 Volume 24 Issue 6 Pages 743-748
Published: December 30, 1984
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA case of bronchiolo-alveolar type papillary adenocarcinoma in a 70-year-old man whose chest X-ray films showed multiple cavities with infiltrative shadows in both lung fields is reported. A large amount (a maximum of 1.1 liters per day) of clear, watery and frothy sputum was produced, associated with cough and dyspnea. Autopsy revealed bronchiolo-alveolar type papillary adenocarcinoma without metastases to any other organ.Multiple cavities in the lungs were filled with mucus.Some of the cavities were circular in shape and had thin walls without any necrosis, which indicated tension cavities, and others were irregular in shape and had thick walls. The mechanisms of cavity formation in this case might include some other mechanisms including the check valve mechanism.View full abstractDownload PDF (8791K) -
H. Masuda, T. Ogata, K. Kikuchi, K. Takagi, K. Sensaki, T. Kawai, M. S ...1984 Volume 24 Issue 6 Pages 749-754
Published: December 30, 1984
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA case of localized fibrous mesothelioma of the pleura was studied histologically, ultrastructurally and immunohistochemically. Tumor tissue located in the right middle lobe was covered by mesothelium. Electron microscopy revealed tumor cells to be plump spindles and fibrocytes. Localized mesothelioma cells showed no staining against keratin antibody immunohistochemically. There was no evidence of epithelial differentiation and these findings indicated that the cells of this tumor were similar to subpleural mesenchymal tissue.View full abstractDownload PDF (9980K) -
Shuji Adachi, Yoshiki Takada, Hideaki Watanabe, Kenichiro Okuda, Masak ...1984 Volume 24 Issue 6 Pages 755-761
Published: December 30, 1984
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSNeurinoma of the tracheobronchial tree is extremely rare and only 33 cases have been previously reported in the literature. In this case, bronchoscopic examination revealed a polypoid tumor in the right main bronchus of a 33-year-old woman which was diagnosed to be neurinoma by biopsy. Subsequently, bronchofiberscopic polypectomy was performed by electrofulguration using a semicircular snare. There was no bleeding and the tumor was completely resected. Eighteen months lates follow-up examination showed no change of the right main bronchus. The procedure is thought to be valuable in the treatment of polypoid tumors originating from the trachea and bronchus. This experience prompted us to report the case with a review of the literatures.View full abstractDownload PDF (11473K) -
Yuji Tohda, Hiroki Uenishi, Kazuhisa Sakamoto, Kimiyo Yamazaki, Yuko K ...1984 Volume 24 Issue 6 Pages 763-767
Published: December 30, 1984
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 62 year-old male case of primary lung cancer with high α-fetoprotein (AFP) levels was reported. He had complained of dry cough and general fatigue since May 1981. An abnormal shadow in the upper field of the right lung was pointed out on chest X-ray film. Serum AFP levels were as high as 18, 000ng/ml, and the CEA and LDH titers were also high. On autopsy only primary lung cancer (small cell carcinoa) was observed and there was no metastasis in the liver or other findings. The results of immunofluorescence studies suggested that the tumor tissue produced AFP.View full abstractDownload PDF (6709K) -
1984 Volume 24 Issue 6 Pages 769-790
Published: December 30, 1984
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (3193K)
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