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Volume 34, Issue 7
Displaying 1-17 of 17 articles from this issue
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Ryuji Inoue, Yoshiki Takada, Kayoko Obayashi, Tetsuji Kado, Hiroyuki Y ...1994 Volume 34 Issue 7 Pages 995-1001
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn patients with unresectable stage III non-small cell lung cancer, we performed chemotherapy and concurrent thoracic radiotherapy.
Thirty-five registered patients were intravenously treated with cisplatin (80mg/m2) on day 1 and vindesine (3mg/m2) on days 1, 3 and were irradiated from days 1 to 10 with single doses of 2.5Gy up to a total dosage of 20Gy. Each course lasted 28 days. Patients received 3 courses, and a total dosage of 60Gy was delivered. Response to this treatment was evaluable in terms of results in 35 patients. Twenty-two patients showed partial response (response rate 62.9%), 10 had no change, and 3 cases had progressive disease. In 7.5 to 37.8 months observation, three PR patients are alive for more than 24 months without recurrence, but eight PR patients died of local relapse, and the median survival time was 15.7 months. Throughout this treatment course, grade 4 leukopenia was noted in 66% and grade 3 thrombocytopenia was obserbed in 3%. However all were reversible condition and no treatment-related death was observed. However, two cases died due to complications of pulmonary abscess, which occured in the area of radiation pulmonary fibrosis about one year later after treatment. Although this concurrent chemo-radiotherapy is a tolerable treatment for non-small cell lung cancer and obtained a good response rate, it did not improve the survival rate.View full abstractDownload PDF (788K) -
Osamu Kawamata1994 Volume 34 Issue 7 Pages 1003-1010
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSc-myc and c-sis mRNA were detected in surgical specimens of non-small cell lung cancer from 34 previously untreated patients: 8 cases of squamous cell carcinoma and 26 cases of adenocarcinoma. In this study in situ hybridization (ISH) disclosed c-myc mRNA in 2 of 8 (25%) squamous cell carcinoma specimens and in 8 of 26 (31%) adenocarcinoma specimens. In addition c-sis mRNA was found in 7 of 26 (27%) tumor cells and 15 of 26 (58%) stromal cells of adenocarcinoma specimens. The appearance of c-myc mRNA correlated with the clinicopathological findings and it tended to be detected more frequently as the clinical stage advanced. When c-sis mRNA was detected both in tumor cells and stromal cells the clinical stage was more advanced.View full abstractDownload PDF (6802K) -
Assessment of Tumor Doubling Time in SurvivalKatsuo Usuda, Yasuki Saito, Hirokazu Aikawa, Yan Chen, Chiaki Endo, Sa ...1994 Volume 34 Issue 7 Pages 1011-1016
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA total of 174 cases with primary lung cancer was examined on survival. Survival rates were compared between some categories in each prognostic factor (univariate analyses), and significant factors affecting survival were obtained by multivariate analyses using Cox's proportional hazard model. Univariate analyses showed a significant difference in survival in relation to tumor doubling time (DT), age, sex, the way how a tumor was detected, smoking history, symptom, therapy, cell type, T factor, N factor, M factor and stage. Multivariate analyses using Cox's proportional hazard model in a stepwise fashion obtained a final set of four significant variables: N factor (p=0.0001); therapy (p=0.0016); DT (p=0.0140) and M factor (p=0.0421). DT was proved to be an independent and significant prognostic factor in lung cancer.View full abstractDownload PDF (603K) -
Kazuhiro Daido, Kenichi Arita, Tsuyoshi Ejima, Reiko Satoh, Megumu Fuj ...1994 Volume 34 Issue 7 Pages 1017-1022
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe authers reviewed the clinical aspects of 5 patients of primary lung cancer with sarcomatous components (sarcomatous carcinoma) treated from 1988 to 1993. The median age was 60.2 years, 2 patients were male and 3 were female. Concerning the epithelial pattern, there were squamous cell carcinoma in 2 cases, and adenocarcinoma, adenosquamous cell carcinoma and large cell carcinoma in 1 case respectively. All cases underwent lobectomy, and 3 cases had postoperative radiation therapy. Two patients lived long periods without disease. Radiation therapy was judged effective for local control of the disease. Sarcomatous carcinoma seemed to be a clinically distinctive disease in primary lung cancer.View full abstractDownload PDF (9285K) -
Hiroshi Niwa, Yosuke Yamakawa, Kaoru Kondo, Ichiro Fukai, Masanobu Kir ...1994 Volume 34 Issue 7 Pages 1023-1028
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDiffuse malignant pleural mesothelioma is an aggressive malignant tumor currently incurable by any form of therapy. Death occurs in most patients within one year of diagnosis, and long-term survival is rare. Previous studies showed that most of the longterm survivors have undergone surgical therapy, but the role of surgery remains controversial. We treated six patients by chemothermotherapy because it is known that hyperthermia is effective for peripleural regions.
Three patients with stage II epithelial type diffuse malignant pleural mesothelioma underwent chemothermotherapy after pleuropneumonectomy. Two patients died 6 and 8 months after operation. One patient is still alive without recurrence 17 months after operation. Three other patients who received exploratory thoracotomy were then treated by chemothermotherapy. Two patients died 11 and 7 months after operation and one patient is alive with recurrence 7 months after operation. Two NCs (no change) and one PD (progressive disease) were observed. Chemothermotherapy combined with pleuropneumonectomy may be effective for diffuse malignant pleural mesothelioma.View full abstractDownload PDF (5694K) -
Yasuharu Ogura, Tadafumi Shimizu, Yasuo Uesugi, Ryuichiro Namba, Yasun ...1994 Volume 34 Issue 7 Pages 1029-1035
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe purpose of this study was to evaluate the clinical usefulness of three-dimensional (3D) images of the bronchi used on helical CT. Fourteen patients with lung cancer, 1 with tracheal diverticulum, and 1 with bronchial amyloidosis were examined. The CT scanner employed was the Toshiba Xforce. The helical CT scan cycle consisted of 20 continuous rotations, each requiring 1.5 sec, for a total scanning time of 30 sec. Scans were obtained using a 5-mm X-ray beam width, a 5-mm/1.5 sec couchtop sliding speed, and a 2-mm reconstruction interval. Three-dimensional images were reconstructed using a CEMAX-VIPstation.
The optimal lower and upper threshold CT values for 3D images of the bronchi were -650 and -100 HU, respectively, and 3D images clearly depicted endobronchial lesions. Cartilage crescents were also demonstrated, but longitudinal and circular mucosal folds could not be visualized. Three-dimensional images of the bronchi using helical CT were useful in evaluating the changes of endobronchial lesions.View full abstractDownload PDF (9553K) -
Hiroshi Nagaoka, Takayoshi Tashiro, Mitsuru Masuda, Tohru Yamasaki, Hi ...1994 Volume 34 Issue 7 Pages 1037-1043
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 74-year-old woman was admitted with left chest pain and exertional dyspnea. A chest X-ray film showed massive pleural effusion of the left side accompanied by mediastinal shift to the right. After drainage of the effusion, an irregular and sharply circumscribed tumor, 80×50mm in diameter, appeared in the left pleural cavity. The tumor was then histopathologically diagnosed as malignant fibrous histiocytoma (MFH) through percutaneous biopsy.
Combination chemotherapy employing cyclophosphamide, vincristin, adriamycin and dacarvazine (CYVADIC) was performed. But the tumor enlarged rapidly, and she died of respiratory failure 8 months after admission.
MFH arising from the chest wall is uncommon, and 25 cases including the present case have been reported in Japan.View full abstractDownload PDF (8214K) -
Akihiro Murotani, Noriaki Tsubota, Masahiro Yoshimura, Yoshiki Takada, ...1994 Volume 34 Issue 7 Pages 1045-1051
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 61-year-old woman was admitted because of bloody sputum. She has been treated for adenoid cystic carcinoma of the carina with irradiation (61.2Gy) and chemotherapy (bleomycin, MMC, and 5-FU) 16 years previously, and had been followed up after complete remission was obtained. Recurrence of the carcinoma at the carina was detected by bronchoscopy. At first, endoscopic polypectomy with diathermy probe was carried out. Two months later, carinal resection and reconstruction was performed. Three years postoperatively, tumor recurrence at the anastomotic site was detected by bronchoscopy. Oblique irradiation (60Gy) was performed and the tumor disappeared again, but multiple lung metastases became evident 2 years later. Control is still good at the anastomotic site, and she remains in relatively good condition at 23 years after the initial presentation.
We concluded that the series of multiple therapeutic procedures to this slow growing but malignant tumor contributed to her long survival.View full abstractDownload PDF (7892K) -
Masaharu Inagaki, Kiyofumi Mitsui, Eiichi Akaogi, Shigemi Ishikawa, Ta ...1994 Volume 34 Issue 7 Pages 1053-1058
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 68-year-old man was admitted to our hospital because of an abnormal shadow on chest roentgenogram. Brushing cytology revealed small cell lung cancer in the right S2b. Biopsy of the mediastinal lymph nodes by mediastinoscopy showed that sarcoid nodules existed in all the biopsied nodes. Therefore, the lymphadenopathy was thought to be sarcoidosis or sarcoid reaction accompanied with lung cancer. Right upper lobectomy and mediastinal lymph node dissection was performed. Although sarcoid nodules were seen in all the dissected lymph nodes, the cancer involved the enlarged paratracheal lymph node. He was discharged after postoperative chemoradiotherapy. Seventeen months after the operation, he shows neither cancer recurrence nor any sign of general sarcoidosis.View full abstractDownload PDF (7038K) -
Takeshi Hatta, Hisanori Ohyabu, Shigeru Kurisu, Syouzou Matsuda, Akihi ...1994 Volume 34 Issue 7 Pages 1059-1063
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 73-year-old man underwent left lower lobectomy on a diagnosis of early stage squamous cell carcinoma of the lung. About one year and six months later, squamous cell carcinoma in the left main bronchus was detected by bronchofiberscopy, and completion pneumonectomy was performed. On pathological examination, this tumor was diagnosed an early cancer and a second primary lung cancer. About one year and seven months after completion pneumonectomy, a tracheal cancer was found and treated by radiation and laser therapy.
Tracheal cancer after completion pneumonectomy is very rare, and there was only 1 reported case of tracheal cancer after completion pneumonectomy during the past ten years in Japan.View full abstractDownload PDF (6955K) -
Osamu Kawashima, Ichiro Yoshida, Yoshimi Ohtani, Susumu Ishikawa, Akio ...1994 Volume 34 Issue 7 Pages 1065-1068
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 54-year-old female was admitted to our hospital because of an abnormal shadow in the right upper lung field on chest X-ray films. There were no malignant signs in the chest tomograms, chest CT scan, chest MRI and bronchofiberscopy. Bronchial arteriograms displayed specific findings of sclerosing hemangioma of the lung (the vascularity of tumor resembles the skin of a musk melon). We performed right upper partial lobectomy, and obtained the histological diagnosis of sclerosing hemangioma of the lung.View full abstractDownload PDF (6152K) -
Kiyoshi Komuta, Syoji Hashimoto, Keiji Maeda, Katsuko Hasegawa, Hideki ...1994 Volume 34 Issue 7 Pages 1069-1073
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 47-year-old female presented with dyspnea on exertion. Chest X-ray and CT taken on admission revealed multiple nodules with cavities and diffuse infiltrations in both lungs. Laboratory findings showed the elevated level of CA19-9 (7612U/1). No evidence of malignancy was revealed by bronchoscopic examinations. To determine the diagnosis, we performed open lung biopsy. Histological examination showed papillary adenocarcinoma (bronchiolo-alveolar carcinoma) of the lung. Immunohistochemical study of lung specimen showed positive staining for CA19-9 on tumor cells. This demonstrated that this case was CA19-9 producing lung cancer.View full abstractDownload PDF (5627K) -
Masaharu Nomura, Masaki Fujimura, Tamotsu Matsuda, Yukihiro Nakamura, ...1994 Volume 34 Issue 7 Pages 1075-1079
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThis report discribes an unusual case of small cell carcinoma of the lung in a 66-yearold man presenting with multiple pleural masses extending along the right pleura without hilar lesions which resembled mesothelioma on chest X-ray film. There were no abnormal findings on flexible bronchofiberscopy. Transbronchial lung biopsy was incomplete, therefore small cell carcinoma was diagnosed by needle aspiration biopsy under CT guidance. This carcinoma showed good response to chemotherapy.View full abstractDownload PDF (5468K) -
Yasuto Akiyama, Haruo Kondo, Mitsuyo Miyazaki, Noriaki Horiuchi, Ryozo ...1994 Volume 34 Issue 7 Pages 1081-1085
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 64-year-old man (Brinkman Index; 800) complaining of cough and fever was admitted to our hospital. Chest X-ray film and CT scans showed a mass shadow in the right upper lobe. Bronchoscopic examination revealed two tumors, a nodular type at the orifice of the left upper lobe bronchus and polypoid type at the orifice of the right upper lobe bronchus. Pathological diagnoses were squamous cell carcinoma and small cell carcinoma, respectively.
After three cycles of chemotherapy, both tumors decreased in size, however another small nodular tumor was also detected at the orifice of right B3 and proved to be squamous cell carcinoma. This is why the reported case was demonstrated to have primary multiple synchronous lung cancer with heterogeneous histological types.
The patient died due to brain metastasis, however relapse of primary tumors in the bilateral upper lobes could not be detected. It was considered that multiple lung cancer case with small cell carcinoma should be treated by means of a combination of therapy including surgery.View full abstractDownload PDF (5950K) -
Hiroyuki Konishi, Osamu Kuwahara, Hajime Maeda, Mitsunori Ohta, Minoru ...1994 Volume 34 Issue 7 Pages 1087-1091
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA case of implantation metastasis after needle biopsy for chest wall metastasis of liposarcoma is reported. A 70-year-old female who had undergone excision of retroperitoneal liposarcoma 8 years previously was admitted to our hospital for examination and treatment of a mass growing from the right chest wall into the thoracic cavity. Needle biopsy with an 18 gauge injection needle and a 19 gauge biopsy needle (Chiba University) only revealed it as a soft tissue tumor. Tumorectomy led to a diagnosis of the myxoid type of liposarcoma which could have been a metastasis of retroperitoneal tumor. Eight months after the operation, local recurrence was found along the needle tract in the subcutaneous tissue, the intercostal muscle, and the right lung. Partial resection of the right upper lobe with combined resection of the chest wall was performed. She was followed for a year and 4 months without recurrence.
Cases of needle tract metastasis have been reported to occur in less than 1% of lung cancer cases. This is the first reported case of needle tract metastasis of liposarcoma. Combined resection of the needle tract with tumor may be necessary to prevent this complication if liposarcoma is diagnosed preoperatively.View full abstractDownload PDF (5839K) -
Ryoji Kawano, Kentaro Kishizuchi, Takashi Nishisaka, Yukio Takeshima, ...1994 Volume 34 Issue 7 Pages 1093-1098
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe pathological findings of three cases of thymic carcinoid tumors (two primary and one recurrent tumors) were studied. The tumors showed classical histological findings of carcinoid tumor, and tumor cells in all cases had argyrophillic granules and showed positive immunoreactivity for chromogranin A and neuron specific enolase. However, nuclear pleomorphism and/or mitotic activities were partially identified in all of the cases, and therefore, the diagnosis of atypical carcinoid tumor was made. Two of the three cases had recurrence or metastasis. The fact that all cases we encountered in the thymus were atypical carcinoid tumor suggests a worse biological character than typical carcinoid tumor derived in the thymus.View full abstractDownload PDF (7371K) -
1994 Volume 34 Issue 7 Pages 1099-1114
Published: December 20, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (2404K)
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