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Volume 11 (1971)
- Issue 4 Pages 277-
- Issue 3 Pages 141-
- Issue 2 Pages 63-
- Issue 1 Pages 3-
Volume 11, Issue 4
Displaying 1-7 of 7 articles from this issue
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Production of ACTH and Serotonin in Oat Cell CarcinomaTakeshi Horai, Hiromu Nishihara, Ryuhei Tateishi, Minoru Matsuda1971 Volume 11 Issue 4 Pages 277-290
Published: December 25, 1971
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSOat cell carcinoma is of great interest in its clinicopathological entity, and its secretion of serotonin or ACTH can be no longer considered to be rare.However, there have been only a few reports concerning oat cell carcinoma secreting serotonin and ACTH simultaneously, where simultaneous production was concluded from clinical laboratory data or from accompa nied carcinoid syndrome and Cushing's syndrome.
Neither carcinoid nor Cushing's syndrome was observed in all the four cases of oat cell carcinoma reported in this paper, but biochemical determinations of humoral and tissue seroto nin and ACTH as well as ultrastructural studies on the tumor tissues indicated that all the tumors produced the biological active substances.
Oat cell carcinoma resembles morphologically to bronchial carcinoid in terms of secretion of serotonin and existence of neurosecretory-type granules in tumor cells.Thus it may be considered that oat cell carcinoma is originated from Kultschitzky-type cells located in bronchi. The cells producing amines such as Kultschitzky cells are considered to be neural crest origin. Cells originated from neural crest may have potential activities of producing serotonin and polypetide hormones such as ACTH, and the activities may be induced by carcinogenesis of these cells.View full abstractDownload PDF (5563K) -
Minoru Matsuda, Ryuhei Tateishi, Takeshi Horai, Shoji Hattori1971 Volume 11 Issue 4 Pages 291-307
Published: December 25, 1971
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSMucoepidermoid tumors originating in the bronchial gland assumed to be rare. Recently, we have had the opportunity to examine6cases of the tumors. Their symptoms and X-ray findings would not appear to be significantly different from those presented in bronchogenic carcinoma. Two of 6 cases were of low-grade malignancy, while the others showed high-grade malignancy, so we asserted that these tumors were treated as the other bronchogenic carcinoma.
On exfoliative cytology of sputum, malignant cells were identified in all cases; dense cytoplasm with vacuoles or with enlarged nucleoli were characteristic.
Light microscopically, round or oval tumor cell nests with a dense fibrous stroma were observed.The cell nests consisted of both squamous and mucous cells. The epidermoid elements proliferated in solid sheets, while the mucinsecreting cells tend to line cystic spaces. Mucin were abundant in most tumors, both intra-and extracellulary. Morphological transition to adenoid cystic carcinoma or giant cell carcinoma was detected in some sites.
Electron microscopically, the tumor cells showed a simillar arrangement to bronchial gland epithelium. The tumor cells were connected each other with thick desmosomes.Abundant tonofilaments together with mucousproducing granules were found in the same tumor cells. We would like to conclude that the cells of bronchial mucoepidermoid tumors had both carac teristics of epidermoid and adenocarcinoma.View full abstractDownload PDF (8760K) -
Evaluation of three procedures (paracarinal biopsy;carinal puncture and mediastinoscopy) in the Leiden UniversityYutaka Yamaguchi1971 Volume 11 Issue 4 Pages 311-320
Published: December 25, 1971
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSThe indication for the surgical treatment of lung cancer can be determined in accordance with vaious methods of examination. The author had the chance to make a research of 466 cases of primary lung cancer at the Leiden University, Netherlands, to investigate how the three procedures on the intrathoracal spread of lung cancer: (1) bronchial mucosa biopsy, (2) carinal puncture and (3)mediastinoscopy: contribute to the decision of operability.
222 cases were found to be inoperable.98 (44.1%) of them were judged non-resectable by way of the three procedures mentioned above. At the Leiden University there is now a rather strict criterion that a case which has a metastasis beyond the superior tracheo-bronchiallymph node, is non-resectable. In spite of this strict criterion still 32 cases could not be ex amined before the operation. These cases were judged to be non-resectable by means of ex ploratory thoracotomies.Techniques of examination for these cases ought to be studied in the future.
At the moment it is not possible to come to a conclusion whether the above mentioned strict criterion will be adopted or to make a positive judgement on the indication for a surgical treat ment even if a mediastinal or subcarinal lymph node metastasis is observed. But it is a problem which has to be reexamined in respect of choice of method of treatment because of a bad prog nosis of resected cases with mediastinal lymph node metastasis.View full abstractDownload PDF (1261K) -
Yukio Shimosato, Kensuke Baba, Toshiro Ogata, Tsuguo Naruke1971 Volume 11 Issue 4 Pages 321-332
Published: December 25, 1971
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSEffects of Mitomycin C injected into the bronchial artery for pulmonary carcinomas were evaluated histologically.They consisted of 62 primary and 6 metastatic carcinomas, and were removed 1 to 30 days after treatment with 10 to 20 mg Mitomycin C.
Effects of the drug varied from area to area in a single tumor.It was more effective for poorly differentiated carcinomas and squamous cell carcinomas than for well differentiated adenocarcinomas.The difference was due partly to the difference in the sensitivity of the tumor cells to the drug, and partly to the difference in the blood supply of the tumors.Although most of the pulmonary carcinomas were believed to be supplied the blood by the bronchial artery, our study suggested strongly that some of the well differentiated adenocarcinoma, especially the areas with the bronchioloalveolar pattern, were nourished by the pulmonary arterial blood.Thus, they have not been effectively treated with the antitumor drug injected into the bronchial artery.
Three years survival rates appeared to have slightly increased in cases with squamous cell carcinoma and have been unchanged in cases with other types of pulmonary carcinomas, as compared with those with no adjuvant therapy.
Side effects (esophageal ulcer 1, esophagobronchial fistula 1, and cutaneous ulcers 2) were observed in 20 mg group.Focal interstitial fibrosis around the tumor was noted in a case treated twice, which was probably due to the opening of bronchopulmonary anastomosis.View full abstractDownload PDF (5001K) -
Ikuro Kimura1971 Volume 11 Issue 4 Pages 333-341
Published: December 25, 1971
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSWe have studied on a total of 96 patients with the lung carcinomas for a period of the past 10 years. By comparing the surviving times in each patient with each medication, we were able to make clear how far a chemotherapy is applicable to the treatment of cancer pa tients. Further, we have investigated its indications and options.
There is a certain discrepancy between tumour responses to treatments (based on mainly the size of tumours) and surviving period of tumour-bering patients; while the tumour did respond well to remedies, the patients did not live longer than we expected. This may be dueto the fact that we are mainly dealing with the far advanced cases of carcinomas.
On the other hand, there is a considerable advantage to consider chemotherapies for treatment of the cancer patients, because of less damage on the host than any other therapies. We have chosen chemotherapies in order to avoid particularly the impairment of the lung among various undesirable side effects.
We combine chemotherapies for the early-diagnosed and-operated patients with other treatments. Thus, we may enhance the cure rate and may achieve a complete cure of these patients. We have found also the combination of a radiotherapy with other medication very promising. The therapy plan is now under progress along this aspect.View full abstractDownload PDF (890K) -
1971 Volume 11 Issue 4 Pages 345-348
Published: December 25, 1971
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSDownload PDF (309K) -
1971 Volume 11 Issue 4 Pages 353-374
Published: December 25, 1971
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSDownload PDF (2461K)
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