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Volume 33, Issue 6
Displaying 1-21 of 21 articles from this issue
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Kazushige Hayakawa, Yoshihiro Saito, Susumu Katano, Masaya Furuta, Mic ...1993 Volume 33 Issue 6 Pages 833-838
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFrom 1976 to 1989, 424 patients with non-small cell lung cancer (NSCLC) were treated curatively with radiation therapy (RT) at our department. Of these, 32 patients with superior sulcus tumor who had no malignant effusion or metastatic disease were identified, and their records were reviewed. RT was administered with 10 MV X-raysusing once-daily fractionation. The overall survivals at 2 and 5 years were 25% and13% respectively (median, 14.5 months), and were similar to those of patients with T3 orT4 tumors at other pulmonary sites. Local control tended to correlate with tumor sizeand hstology. As a result, the outcome was related to local control, tumor size andhistology. Concerning of histologic types, 5-year survivors consisted of 4 (16%) of casesof squamous cell carcinoma compared with none in those with non-squamous cell carcinoma.All patients had relief of symptoms such as pain or SVC syndrome after RT.Primary curative RT is not only useful for palliation but can also offer a realisticpossibility of long-term survival in some patients with superior sulcus tumor.View full abstractDownload PDF (723K) -
Wataru Chiba, Satoru Sawai, Takeshi Hanawa, Teruo Matsui, Satoshi Wata ...1993 Volume 33 Issue 6 Pages 839-845
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe examined 143 cases of untreated lung cancer before operation for amplificationof the c-erbB-2 gene by slot blot hybridization. The samples were stored at-90°C untilanalysis. There were 22 cases of amplification of the c-erbB-2 gene. The minimumnumber of copies was 2.00 fold, the maximum number of copies was 12.50 fold, and themean number of copies was 3.37 fold. The incidence of amplification of the c-erbB-2gene in relation to the clinical stage was 6 cases (13%) in stage I, 2 (17%) in stage II, 6 (12%) in stage III A, 6 (27%) in stage III B, and 2 (17%) in stage N. There was nocorrelation between amplification and clinical stage. The incidence of amplificationaccording to histological type was 20% in adenocarcinoma, 8% in squamous cell carcinoma, and 40% in small cell carcinoma. There were thus more cases of c-erbB-2amplification in adenocarcinoma and small cell carcinoma than in squamous cell carcinoma.For the c-erbB-2 amplified cases, the five-year survival rate of the curativeresectioncases was 40%, and that of the non-curative-resection cases was 38%. Thedifference between these rates was not significant in c-erbB-2 amplified cases. For thenon-amplified cases, the five-year survival rate of the curative-resection cases was 53%, and that of the non-curative-resection cases was 27%, and this difference was significant (p<0.01). Thus, there is a possibility that amplification of the c-erbB-2 gene itself is aprogostic factor in sected lung cancer regardless whether resection was curative ornon-curative.View full abstractDownload PDF (3399K) -
by Thin-slice Computed Tomography Based on Radiologic-Pathologic CorrelationKouzo Yamada, Teruaki Yoshioka, Ikuo Nomura, Masanori Matsumura, Kazum ...1993 Volume 33 Issue 6 Pages 847-855
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn order to analyze radiographic findings of small solitary pulmonary nodules, we retrospectively studied thin-slice computed tomography (thin-slice CT) images using a 2 mm scan. There were 20 patients with lung cancer and 21 patients with benign lesions less than 30 mm in diameter. CT images were examined by an extended scale (window level:-600 HU, window width: 1900 HU).
In thin-slice CT images, findings of all lesions were classified into two different patterns (solid type and infiltrative type) based on the growth pattern of the lesion. The margin of solid type lung cancers as seen on thin-slice CT images showed spiculation or irregular undulations which were never seen on thin-slice CT of benign lesions. On the other hand, the margin of infiltrative type lung cancers and some benign lesions as seen on thin-slice CT images showed spiculation.
Our results suggest that thin-slice CT may have a significant clinical role in differentiating lung cancer appearing as a small solid type solitary pulmonary nodule from benign lesions by demonstrating the findings of spiculation or irregular undulations. To obtain more precise differential diagnosis of small solitary pulmonary nodules, it is necessary to accumulate more knowledge concerning radiologic-pathologic correlation.View full abstractDownload PDF (8274K) -
Atsuhiko Tada, Shin Kawahara, Chiharu Okada, Masayoshi Kibata1993 Volume 33 Issue 6 Pages 857-863
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFifteen cases of coexisting lung cancer and active pulmonary mycobacterial disease who had been admitted to our hospital during the past ten years, were studied clinically. Histological types of lung cancer were squamous cell carcinoma in 9, adenocarcinoma in 4 and small cell carcinoma in 2. The species of mycobacteria were M. tuberculosis in 12 and M. avium complex in 3. In 9 cases, the foci of cancer and of mycobacterial disease were found in the same lobe. Six cases suffered from pulmonary mycobacterial disease during the course of lung cancer. In 9 cases, lung cancer was found during chemotherapy of pulmonary mycobacterial disease. In all these 9 cases, retrospective studies of X-ray films revealed that the tumor shadow of the lung cancer was recognized at the time of admission to our hospital. In 6 of these 9 cases, it was thought that the onset of lung cancer was followed by that of mycobacterial disease. From these results, it should be noticed that latent lung cancer may be present in cases of mycobacterial disease.View full abstractDownload PDF (815K) -
Kenichi Gemba, Taisuke Ohnoshi, Hiroshi Ueoka, Katsuyuki Kiura, Masahi ...1993 Volume 33 Issue 6 Pages 865-869
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSBetween 1976 and 1991, 21 patients (4.5%) developed metastasis to the skin among 468 patients with lung cancer treated in the Medical Oncology Department of Okayama University Hospital. Histologically, adenocarcinoma (6.7%) was frequent. Clinical manifestations of skin metastasis consisted of nodular type in 17 patients (single 3, multiple 14), erysipelatous carcinoma in 2 patients, and cancer en cuirasse in 2 patients. At the development of skin metastasis, all cases were accompanied by metastases in other organs. Median survival time after development of skin metastasis was only 3.6 months.
These results indicate that skin metastasis is a part of the process of systemic metastasis and that the prognosis after development of skin metastasis is poor.View full abstractDownload PDF (555K) -
Katashi Satoh, Takuya Kobayashi, Yoshirou Kawase, Shinsuke Matsuno, No ...1993 Volume 33 Issue 6 Pages 871-877
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFor precise interpretation of radiological findings, Heitzman's inflated-fixed lung method is important. This method, however, has the significant disadvantage of bad staining; pyknosis, detachment of cilia and lack of clarity of cytoplasm. We developed an improved method in small lungs of canines by fixation and distension with formalin prior to the original method in order to obtain both high quality of staining and radiographs. But in some human specimens, we could not obtain satisfactory results. In the present study we assessed the suitable fixation time for lung cancer specimens using this method. Ten resected lobes of peripheral type lung cancers were examined. Fixation times assessed were 15 minutes in 1 case, 3 to 4 hours in 4, and 2 to 4 days in 5. The staining and the radiographs of the specimen were compared to those of the original method and CT. In the specimens of fixation for 15 minutes, there were both areas of good and bad staining within them and good radiographic findings were obtained. In the other cases, staining was satisfactory, but specimens shrank in the two cases of fixation for 3 and 4 days. Fixation and distension with formalin for 3 or 4 hours prior to performing the original method yielded both high quality staining and radiographs of the specimen.View full abstractDownload PDF (11026K) -
Taisuke Ohnoshi, Hiroshi Ueoka, Shin Kawahara, Katsuyuki Kiura, Masahi ...1993 Volume 33 Issue 6 Pages 879-886
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe evaluated the long-term outcome of 112 patients with small cell lung cancer (SCLC) treated with COMP-VAN alternating chemotherapy between 1981 and 1986. The chemotherapy consisted of a combination of cyclophosphamide, vincristine, methotrexate, and procarbazine (COMP), alternating every four weeks with a combination of etoposide, adriamycin, and nimustine (VAN). Randomized trials of chest irradiation (chest RT) of 40 Gy for patients with limited disease (LD) and prophylactic cranial irradiation (PCI) of 40 Gy for complete responders were conducted simultaneously. Fifty-four patients with LD and 56 with extensive disease (ED) were fully evaluated. Two patients who developed fatal radiation-induced pneumonitis were excluded from the evaluation of tumor response and relapse site. The overall response rate was 89% for both LD and ED patients, with a CR rate of 56% for LD and 32% for ED patients. The median survival time was 14.5 months for LD patients and 11.1 months for ED patients, and the 3-year, 5-year and 10-year survival rates were 17.9%, 14.3%, 9.4% for LD patients and 3.6%, 0%, 0% for ED patients, respectively. Cumulative actuarial relapse rate in the chest or brain was significantly less frequent in the chest RT group and PCI group than the respective control groups, however, no meaningful survival benefit was obtained by chest RT and/or PCI. The dose-limiting toxicity for chemotherapy was leukopenia, and 70% of patients encountered grade 3 or 4 leukopenia. With chest RT, esophageal irritation occurred in 46% of patients irradiated, but it was well tolerated. Radiation pneumonitis occurred in 29% of those irradiated, including 2 fatal episodes. Although a substantial proportion of patients achieved a, long-term survival by the alternating chemotherapy, further investigation is required to achieve better outcome in the treatment of SCLC.View full abstractDownload PDF (907K) -
Takashi Hirano, Norihiko Ikeda, Toshimitsu Hiyoshi, Ken Okuzawa, Touic ...1993 Volume 33 Issue 6 Pages 887-895
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn our department 39 patients (2.02% of all patients treated for primary lung cancer) were diagnosed as multiple primary lung cancer (MPLC) between January 1977 and March 1991. In 18 of these MPLC cases both lesions were judged to be stage I. (We call such cases stage I MPLC.) Combination with mass surveys including chest X-ray and sputum cytology, and periodical detailed examinations of patients with primary lung cancer (PLC) increased the rate of relatively early detected cases.
The 5-year survival of cases with synchronous disease was 45.1%. In metachronous disease the rates after the detection of the first cancer and after that of the second cancer were 70.6% and 46.9%, respectively. In stage I MPLC case the 5-year survival rate for synchronous disease was 80.0%, and the rates for metachronous disease after the initial detection and after the development of a metachronous lesion were 71.4% and 66.7%, respectively. No statistical difference was observed between stage I MPLC cases and stage I PLC cases in 5-year survival. The prognosis of MPLC is not very bad, when the lesion is discovered at an early stage.View full abstractDownload PDF (1103K) -
Staining Patterns of Resected Specimens and Transbronchial Biopsy Specimens-Norihiro Orihashi1993 Volume 33 Issue 6 Pages 897-905
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSProliferating cell nuclear antigen (PCNA) is a nuclear protein synthesized in the late G1 and S phase of the cell cycle, and is an immunohistochemically useful marker for proliferative cells in tissue specimens. A series of squamous cell carcinoma (SCC) of the lung, including 52 resected specimens and 30 preoperative transbronchial biopsy specimens, was evaluated by monoclonal anti-PCNA antibody (PC10) using the streptavidin biotin immunoperoxidase method.
No correlations were observed among the PCNA positive rate (labeling index) of resected specimens and p TN or prognosis. However, the PCNA immunostainingpattern (P-strong peripheral staining in tumor nests, D-diffuse staining in tumor nests, M-mixed) was diversely observed, reflecting the grade of differentiation in the tumor. The P or M +D staining pattern showed an agreement of 80%(24 in 30 case) between resected specimens and preoperative transbronchial biopsy specimens. Concerning biopsy specimens, the D pattern was observed more frequently in peripheral type SCC (8/9 cases) compared to central type SCC (8/21 cases), and more commonly in females (6/7 cases) than in males (10/23 cases).
These findings suggest that PCNA may be a useful marker not only to evaluate tumor character based on biopsy specimens, but also to analyze the degree of differentiation in SCC of the lung.View full abstractDownload PDF (3385K) -
within Primary Tumors of Squamous Cell and Adenocarcinoma of the LungHidemi Ohwada, Masahiko Ishibashi, Kenzo Hiroshima, Yutaka Hayashi1993 Volume 33 Issue 6 Pages 907-916
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn order to compare the activity of lung cancer cells in the central zones of lesions with cells in the peripheral zones of the tumor, we examined 29 resected specimens of primary lung cancer in terms of argyrophilic nucleolar organizer regions (AgNORs) and immunoreactivity of proliferating cell nuclear antigen (PCNA). The 29 resected specimens consisted of 9 squamous cell carcinomas, 10 papillary adenocarcinomas, and 10 tubular adenocarcinomas.
We measured the rate of immunoreactivity of PCNA and the number of Ag NORs of cancer cells located in the central zone and peripheral zone within a given cancer nodule respectively.
We obtained the following results. (1) There were larger numbers of Ag NORs per single cancer cell located in the central zone than in the peripheral zone regardless of histologic type and differentiation. (2) The number of Ag NORs per single cancer cell increased as the degree of cancer differentiation decreased. (3) The rate of positive reaction to PCNA in cancer cells located in the peripheral zone was higher than that in the central zone, apart from cases of poorly differentiated squamous cell carcinoma.
These results reveal that there is a discrepancy between average number of Ag NORs and rate of positive reaction to PCNA in cancer cells, and suggest that an increased number of Ag NORs is involved in the differentiation of cancer cells.View full abstractDownload PDF (9407K) -
Chiharu Yoshii, Yasuo Morimoto, Yoshihiko Nikaido, Yoshiaki Tao, Tohru ...1993 Volume 33 Issue 6 Pages 917-923
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSrG-CSF is administered with antineoplastic drugs in patients with lung cancer in order to increase the level of white blood cell (WBC) counts or shorten the duration of leukocytopenia. However, it has not been determined when it is best to commence to administer r G-CSF. In this study, we investigated WBC counts at the nadir and the duration of leukocytopenia in three different chemotherapy regimens among four groups classified by commencement of rG-CSF administration, namely, Group A: without rGCSF, Group B: commencement from the day when WBC counts decreased below 2000/mm3, Group C: commencement from day 2, Group D: commencement from day 5. In group D, WBC counts at the nadir were significantly increased compared with group A and were maintained above 2000/mm3 in all cases. In groups B and C, the duration of leukocytopenia was shortened compared with group A in the patients given the same chemotherapy regimens. Our results support recommending starting rG-CSF administration from day 5 in these chemotherapy regimens to increase WBC counts at the nadir and shorten the duration of leukocytopenia.View full abstractDownload PDF (642K) -
Hiroyuki Nakamura, Kousuke Kasiwabara, Yuuji Fukai, Hiroshi Semba, Ryo ...1993 Volume 33 Issue 6 Pages 925-928
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 57-year-old man was diagnosed as having systemic lupus erythematosus in 1980. He was given 17.5 mg/day of oral prednisolone as maintenance therapy, but developed a cough in early October 1987. Chest X-ray revealed a tumor measuring 9 x 10 cm at the hilum of the right lung. Sputum cytology revealed the presence of small cell cancer cells. Granular changes all around the right truncus intermedius were observed by bronchoscopic examination, and brushing cytology and tissue biopsies of this site confirmed the diagnosis of small cell lung cancer (C-T3N2M0, L. D.). Multi-drug chemotherapy with CDDP and VP-16 led to complete response (CR), and thereafter radiotherapy (50Gy) was performed. Five years have passed since he showed CR and he is now alive with no sign of relapse. To our knowledge, there has not yet been any report on SLE complicated by small cell lung cancer. Furthermore, this patient showed CR for more than 5 years. A review and discussion of the literature is included.View full abstractDownload PDF (4596K) -
Rie Sugihara, Osamu Onizuka, Takehiko Shigenaga, Akiko Kaneko, Tomiyas ...1993 Volume 33 Issue 6 Pages 929-934
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 80-year-old woman with endobronchial non-Hodgkin's lymphoma was reported. Chest X-ray on admission revealed a solitary nodular shadow in the left lower lung field and left hilar lymph node swelling appeared to be a primary lung cancer. Bronchoscopic examination showed a mass resembling a small cell carcinoma at the bifurcation of left Blo. Microscopic examination of the biopsy specimen obtained from the mass showed non-Hodgkin's lymphoma (B cell, diffuse, medium cell type).
In this case, ascites and a large mass lesion in the retroperitoneal space were found simultaneously. Cytological examination of ascites also showed malignant lymphoma. From the chest X-ray and bronchoscopic findings, it was suggested that malignant lymphoma originated from BALT or lymph nodes invading the bronchus and formed an endobronchial mass.View full abstractDownload PDF (9600K) -
Koichi Tanaka, Takashi Miura, Tetsuo Hadama, Yuzo Uchida, Shigeo Yokoy ...1993 Volume 33 Issue 6 Pages 935-939
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe authors experienced a rare case of malignant pleural mesothelioma with longterm survival following pleuropneumonectomy. A 48-year-old female was admitted to our hospital with persistent pleural effusion in February, 1985. Cytological examination yielded a suspicion of malignant mesothelioma. Pleural effusion had been pointed out on chest X-ray film, and she had received drug therapy under a suspicion of tuberculous pleuritis since November, 1982. At surgery, multiple fungus-like protrusions were recognized from the parietal and visceral pleura with small amounts of effusion. When the diagnosis of malignant mesothelioma was established by biopsy, pleuropneumonectomy was performed. However, complete resection of the tumor was not possible because of massive tumor invasion, particularly to the pericardium and diaphragm. Histologic findings showed well differentiated papillary or tubular proliferation of tumor cells with collagen fiber stroma, confirming the diagnosis of diffuse epithelial mesothelioma. Lymph node metastasis was not detected. Futraful (600mg/day) was given orally for about 5 years, and she is doing well with no recurrence 8 years after the operation.View full abstractDownload PDF (5832K) -
Yosuke Aoki, Naoko Sueoka, Yoshiaki Nakahara, Shigetaka Kuroki, Osamu ...1993 Volume 33 Issue 6 Pages 941-945
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 75-year-old man complaining of cough with roentgenologic features suggesting lung cancer in the left lung underwent bronchoscopy. The orifice of left B9 was occluded by an endobronchial polypoid tumor, the tip of which was covered with necrotic tissue. In addition, the orifice of right B9 was also occluded by a tumor showing the same bronchoscopic appearance as that in the left. These two tumors proved histologically to be poorly differentiated adenocarcinoma, and were strongly suspected to be metastatic endobronchial lesions from an extrathoracic malignancy. Chest CT detected a parenchymal mass 3cm in diameter adjacent to the left B9 endobronchial tumor and several small nodules suggestive of metastatic foci in both lungs. However, subsequent systemic studies found no evidence of malignancy in any other organs apart from the lungs. The endobronchial nodule at the orifice of right B9 was revealed by chest CT to be an intraluminal polyp without parenchymal involvement.
Taking these results into consideration, we concluded that a primary adenocarcinoma of the left lung grew endobronchially, and caused an endobronchial metastasis in the contralateral lung.View full abstractDownload PDF (6231K) -
Akira Shoji, Masanobu Eguchi, Masao Nakamura1993 Volume 33 Issue 6 Pages 947-952
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 61-year-old female was admitted with complaints of cough and dyspnea on effort. Chest X-ray revealed left pleural effusion. Cytological examination of the pleural effusion revealed adenocarcinoma. Carcinomatous pleuritis due to adenocarcinoma of the lung was diagnosed and she was treated with general and local (intrathoracic) chemotherapy. However, she died 100 days after admission. Her peripheral white blood cell count was 8, 000/mm3 on admission, and increased steadily to 106, 000/mm3 of which 97% were mature neutrophils, in spite of no obvious infection. Enzyme immunoassay demonstrated an apparent increase of granulocyte colony stimulating factor (G-CSF) in the serum. Immunohistochemical examination of the tumor cells showed positive staining for anti-G-CSF monoclonal antibody. Therefore, this case was diagnosed as adenocarcinoma of the lung producing G-CSF. On admission, when the peripheral white blood cell count was normal, tumor cells stained positively. This suggests that leukocytosis occurring at 2 months after admission was related to the gross quantity of GCSF of the serum, not to the existence of the ability to produce it.View full abstractDownload PDF (4747K) -
Keiko Inatomi, Toshimichi Ootsuka, Yoshinari Murota, Kinya Hayakawa1993 Volume 33 Issue 6 Pages 953-957
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 52-year-old man was admitted to our hospital for a general check up. Chest roentgenogram revealed a small coin lesion (8×8 mm) in the left lower lung field. No abnormal shadow was found on the plain chest X-ray film on a regular health examination performed 4 months previously. He had been sufferring from mild cough and sputum and was a heavy smoker with a history of sinusitis. Because his erythrocyte sedimentation rate was high, he was treated for sinobronchitis for two weeks. Cytological findings of sputa were diagnosed as class II-IIIa. Bronchoscopy revealed no abnormal findings in the bronchial wall. Lung cancer was not excluded by these data, therefore open thoracotomy was done. Pathological examination revealed a subpleural lymph node with anthracosis located in S5. It should be noted that small pulmonary nodules in the subpleural region of the lung might be intrapulmonary lymph nodes.We summarized 7 cases including 6 reported cases in Japan.View full abstractDownload PDF (4736K) -
Masahiko Takenaka, Takashi Nakano, Noriaki Iwahashi, Toshikazu Hada, K ...1993 Volume 33 Issue 6 Pages 959-964
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 47-year-old male had experienced pneumonia 4 times in the past (at age 4, 36, 37 and 39 years old). His emphysematous bulla was first recognized when the last pneumonia developed. Eight years after the last pneumonia, he had pneumonia which rapidly improved by treatment with antibiotics. However three months later, he was admitted to our department because of fever and a mass lesion on chest X-ray. The chest X-ray on admission showed that a tumor adjacent to the bullae had developed during the past 8 years. Since percutaneous biopsy demonstrated adenocarcinoma of the lung histologically, lobectomy of the right upper lobe containing the tumor was performed. At operation, a tumor adherent to the bullae was found in the anterior segment of the right upper lobe. The postoperative course was uneventful. He is well 8 months after operation, however he has atypical mycobacteriosis. There has been no sign of recurrence of lung cancer.View full abstractDownload PDF (9968K) -
Ryohei Yamashita, Katsuya Morita, Mitsuyo Kosugi, Chyo Kobayashi, Yuse ...1993 Volume 33 Issue 6 Pages 965-969
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAn abnormal shadow of the left lung was pointed out in a 55-year-old female during a mass screening for lung cancer. Chest roentgenogram and CT on admission showed a 2-cm nodular lesion in the left S3. Transbronchoscopic brushing biopsy of the left B3 demonstrated carcinoma cells including signet-ring cells. At first, this pulmonary lesion was thought to be a metastatic tumor from a digestive tract malignancy, particularly the stomach. Since a thorough work-up, including abdominal CT and endoscopy of the upper and lower gastrointestinal tract, failed to reveal any other tumor except for the pulmonary lesion, this was interpreted as a primary pulmonary adenocarcinoma. The patient underwent a left upper lobectomy. On microscopic examination of the resected specimen, the pulmonary tumor was composed entirely of sheets of signet-ring cells arranged in an alveolar pattern. The pathologic diagnosis was signet-ring cell carcinoma of the lung.
Signet-ring cell carcinomas are generally found in the digestive organs. Although rare, it should be taken into consideration that signet-ring cell carcinoma can exist as a primary tumor of the lung, as in the present case.View full abstractDownload PDF (10564K) -
Takeshi Isobe, Takafumi Tsuya, Kenji Niitani, Yasuhiro Yoshida, Kenji ...1993 Volume 33 Issue 6 Pages 971-976
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 63-year-old female case of adenocarcinoma of the lung associated with pulmonary sarcoidosis is reported. Bilateral hilar lymphadenopathy (BHL) was pointed out on a mass survey and sarcoidosis was diagnosed by supraclavicular lymph node biopsy in 1977. During 5 years of follow up, her chest X-ray showed improvement of the BHL, but her lung fibrosis increased gradually, and showed a tumor shadow in the left upper lung field in 1985. She was admitted to our hospital in 1987, and diagnosed as lung cancer by bronchofiberscopic cytology. After left upper lobectomy, histological examination of the resected lung revealed adenocarcinoma and chronic granulomatous inflammation suggesting sarcoidosis. Coexistence of sarcoidosis and lung cancer is unusual and the relationship between these two diseases is not clear.View full abstractDownload PDF (6974K) -
1993 Volume 33 Issue 6 Pages 977-990
Published: October 20, 1993
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (2002K)
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