The gross findings and growth processes of 136 cases of pulmonary carcinoma were studied, categorising them according to the site of origin; hilar, intermediate and peripheral. In early stage squamous cell carcinoma in the hilar region, the author classified four subtypes according to intrabronchial growth, i.e. polypoid, nodular infiltrative, superficially infiltrative and ulcer subtypes, and even in the superficially infiltrative type there were macroscopical differences between intramucosal, intracartil age and extracartilage invasion. It was recognized that the longitudinal mucosal fold of the bronchial epithelium should be observed for signs of tumor cell invasion. In intramucosally infiltrating cases or early invasive cases, thickening of the longitudinal mucosal fold and granulation of the mucosa can be seen. However in cases of invasion, the longitudinal mucosal fold disappeared. Differences between polypoid and the nodular infiltrating type in other histologic types of pulmonary carcinoma were noted. Also, differences with intermediate or peripheral cases of other histologic types were pointed out.

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Male or female rabbits weighing about 2Kg were fed on dried pellet diet, and MNNG solution of 15 to 300μg/ml was administered continuously or intermittently for six to twelve months.
Sixteen of the forty rabbits had tumors located in the larynges, tracheae or central bronchi. Cytological diagnosis of the induced cancer was possible by the tracheo bronchial brushing of rabbits just before death.
All of the tumors were histologically diagnosed as squamous cell carcinomas, each being localized within the adventitia of tracheobronchial wall without any metastasis. So, they proved useful as an experimental model for the early human bronchogenic cancer of central type.

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We have treated the 18 cases of small cell cancer of the lung in our hospital.
Amont them, operation cases area only 2 cases, one cases (T₁ N₀ M₀) out of them is now alive, the other case (T₃ N₁ M₁) combined with Linac and FAMT is dead of Radiation damage.
The combined therapy with chemo and radiation are performed with Vincristin and Linac, for 16 cases, the other 2 cases, Adriasin and Linac.
The survival rates of each groups are as follows; T₁ N₀ M₀; 9.5M T₁ N₁ M₀; 14M T_1-3 N₁ M₁; 8.2M.
The factors making prognosis worser are considered as follows; 1) Penumonia, 2 cases, acute diffuse interstitial pneumonitis due to combined therapy, 1 cases 2) very poorly differented type (difficult to crassify into large or adeno) were seen in 4 cases.
The lung cancer of this type is apt to metastase to other organs (i. g, brain, bone etc.) and have many complications by radiation therapy.
Paying attention to the points above related and establishing the future therapy is important to elavate the results of the therapy.

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There are two purposes for the treatment of the patients with lung carcinoma. One is for the curative, that is to improve five year survival rate, and the other is for the palliative, that is to improve the time period of surviving as well as to eliminate the complaint the patients severely suffering.
Radiation treatment could be effective to cure the patients with lung carcinoma if they are in earlier stages, however the most of the cases revealed too advanced to be cured, so it is valuable to treat them for the palliative.
During the 12 years period since May, 1962 through October, 1974 at National Cancer Center Hospital. We have studied 631 cases with primary lung cancer which were treated with external radiation. The survival rate was examined in these cases from the point of view of radiation treatment with several comments added.
The over-all survival at five years was 13 (3.1%) out of 418 cases. Histologically, the cases with squamous cell carcinoma revealed 3 (2.1%) survivors at three years out of 143 cases, those with adenocarcinoma 6 (3.7%) of 164 cases, those with undif ferentiated large cell carcinoma 1 (2.9%) of 34 cases and those with undifferentiated small cell carcinoma 3 (3.9%) of 77 cases. Viewing from the stage of the disease, the five year survival was 6 (22.2%) out of 27 cases with Stage I, 3 (16.7%) out of 18 cases with Stage II and 4 (1.1%) out of 373 cases with Stage III.
From the point of radiation treatment, one of the advantages of this combination was that the extent of the cancer in the lung and the mediastinum was well demon strated by the bronchial-arteriography. This was important to decide the field for radiation treatment. The second advantage of this technique was that the tumor dose of radiation could be reduced by adding local administration of anti-cancer drugs through the bronchial artery. This meant that we could decrease radiation dose to the vital organs of the lung and the heart.

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The authors made statistical comparisons between survival times of histologically proven 1, 827 patients and those of non-proven 964 patients with lung cancer according to TNM classification, clinical staging and sex.
The survival data foranalysis were collected from 107 hospitals in Japan during the period 1967 to 1969.
In this study, the cytologically proven 546 cases did not include among the histo logical proof groups.
From the statistical analysis, the survival-time distribution of the proven group was superior to that of the non-proven group in a following factors; M0, N0, T1, T2, stage I, stage II of males.
The differences between the two groups were statistically significant.

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