Surgically resected lungs with the primary lung cancer (100 males, 40 females) and with other pulmonary disease (28 males, 21 females) were histologically investigated with special references to the relationship between squamous metaplasia orbasal cell hyperplasia of bronchial epithelium and histological types of the carcinoma, sex, preoperative radiotherapy and subepithelial inflammatory cell infiltration.
The grade of squamous metaplasia in the lung cancer cases was not related tothe histological types of the cases.
The grade of basal cell hyperplasia was related to the grade of inflammatory cellinfiltration in the subepithelial layer. However, the grade of squamous metaplasia inbronchial epithelium was not directly associated with inflammatory cell infiltrationin the subepithelial layer.
The squamous metaplasia was more extentively observed in the aged group (morethan 60 years) than in the younger group, but the smoking habit exhibited moremarked effect on the developement of the squamous metaplasia.
Among the cases with the similar smoking habits, however, the primary lung cancercases showed more remarkable squamous metaplasia than in the non-lung cancer cases.
The influences of preoperative radiotherapy on the developement of squamousmetaplasia in the bronchial epithelium was not recognized in the cases of epidermoid cancer investigated in this study.
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