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Volume 26, Issue 1
Displaying 1-13 of 13 articles from this issue
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Kenkichi Oho, Ryuta Amemiya, Masahiro Kaneko, Tetsuro Kodama, Masahiro ...1986 Volume 26 Issue 1 Pages 1-10
Published: February 28, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe Japan Lung Cancer Society created a classification of the bronchoscopic findings in lung cancer cases in 1979 (committee chairman: Yoshihiro Hayata). Since then further progress has been made in the analysis of endoscopic findings and new thinking concerning endoscopic findings has gradually evolved and it is now unavoidable to revise the classification of bronchoscopic findings in lung cancer cases.
The revised classification was based upon a thorough crossreference between histopatho-logical evaluation of the proliferation and development of lesions and the endoscopic findings. The endoscopic appearance caused by the invasion of lung cancer was recla: sified in terms of changes in each layer of the bronchial wall in order to allow precise evaluation of the depth and direction of invasion.
The bronchoscopic findings in lung cancer must be evaluated from a 3-dimensional perspective, i.e. considering the surface extent of the lesion along the histological structure of the bronchial wall and also the depth of invasion. Such precise classification and evaluation of lesions is considered to be helpful in evaluating histologic type, for clinical staging, deciding on the indications of surgery and the type of surgical procedure to be employed, in addition to evaluating therapeutic effectiveness.View full abstractDownload PDF (10690K) -
Fluorescence Cytophotometric Nuclear DNA AnalysisMasashiro Yamazaki, Masayoshi Takahashi, Masahiko Fujii, Kei Hagiwara, ...1986 Volume 26 Issue 1 Pages 11-18
Published: February 28, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe have sequentially observed histological and cytological alterations in bronchial epithelial cells of 9 heavy smokers. Nuclear DNA contents of bronchial epithelial cells in these cases were also measured by cytofluorometry.
Eight of the cases were diagnosed as either basal cell hyperplasia, squamous cel l metaplasia or squamous cell metaplasia with mild atypia. One case was diagnosed as carcinoma in situ on the first biopsy. The 8 cases did not advance beyond squamous cell metaplasia to severe atypia or epidermoid carcinoma. The single case of carcinoma in situ did not return forsubsequent examinations for 44 months. The biopsy then showed invasive epidermoid carcinoma.
DNA histograms of the bronchial epithelium were as follows: basal cell hyperplasia or squamous cell metaplasia, 2C mode and ranging from 2C to 4C; squamous cell metaplasia, with mild or moderate atypia, hyper 2C mode and ranging from 2C to 6C; carcinoma in situ, polyploid pattern and ranging from 4C to 10C; invasive epidermoid carcinoma, aneuploid pattern spreading over 10C.View full abstractDownload PDF (4554K) -
Takashi Oiwa, Hiroko Saito1986 Volume 26 Issue 1 Pages 19-25
Published: February 28, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo evaluate the technique for cytological diagnosis of primary lung cancer, transbronchial aspiration cytology (TBAC), TBAC was performed in 131 lung cancer patients. Cancer cells were obtained in 129 cases (98.9%). In peripheral lung cancer cases, 43 of 44 cases (97.7%) were positive for malignancy and in Tl cases, 13 of 14 cases (93%) were also positive.
Correlation between cytological diagnosis and histological diagnosis showed a high rate of coincidence of 92%
Complications consisted of a slight degree of pneumothorax in only one case and no severe intrabronchial bleeding was observed.
The advantages of TBAC in comparison with other cell collecting methods for cytological diagnosis of lung cancer were as following, its safety, high positive ratio, good amount of tumor cells collection and easiness to diagnose histological type.
It was confirmed that TBAC is an excellent cytological diagnostic method for lung cancer.View full abstractDownload PDF (794K) -
Koji Kimino, Hiroyoshi Ayabe, Katsunobu Kawahara, Yasushi Tagawa, Yuji ...1986 Volume 26 Issue 1 Pages 27-35
Published: February 28, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe accuracy of ultrasonography (US) and computed tomography (CT) were compared in the evaluation of the extent to the chest wall and the pleura in 34 cases of primary lung cancer in the vicinity of the chest wall.
The percent accuracy of US evaluation of parietal and visceral pleural invasion was 62% and that of CT for chest wall invasion was 74%. US and CT both displayed a tendency to overestimate extent. Inaccurate estimation by US included 13 cases, 69.2% among which had pleural indentation. Most mistakenly estimated as Surgical-P had pleural indentation as well. Overestimation by CT was recognized in 3 cases, 2 of which had atelectasis and the other pleural adhesion. The diagnosis of P-factor by US as well as the findings at surgery were difficult in cases having pleural indentation and evaluation of chest wall invasion by CT was also difficult in cases with atelectasis and pleural adhesion.
The sensitivities of US and CT were both 90%. Both methods were useful in the evaluation of chest wall involvement. US was superior to CT with respect to demonstration of more detailed visceral pleural change and respiratory movement of the tumor mass and the pleura can be observed. Therefore, US and CT should be utilized to assess chest wall and pleural involvement in cases with lung cancer in the vicinity of the chest wall.View full abstractDownload PDF (10895K) -
Akio Terazawa1986 Volume 26 Issue 1 Pages 37-45
Published: February 28, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSNatural Killer (NK) activity of peripheral mononuclear cells in 60 patients with lung cancer was examined, and analyzed for various stages and histological types. Stage IV cases showed depression of NK activity in comparison to stage I and control groups. In patients with adenocarcinoma the NK activity was lower than that in patients with squamous cell carcinoma. Persistent depression of NK activity was seen in patients with neoplastic involvement of multiple organs and in juvenile patients with double primary carcinoma. The data were also analyzed to evaluate the influence of surgical intervention and adjuvant chemotherapy on NK activity. The rate of NK recovery from surgical stress at 1 week after operation was depressed in elderly patients, the recovery rate at 2 weeks in patients with greater surgical blood loss, as was that at 3 weeks in stage IV cases with prolonged surgical operation. Adjuvant anticancer chemotherapy did not cause any significant depression of NK activity.View full abstractDownload PDF (1053K) -
Surgical Treatment of Lung Cancer Involving Neighboring Organs in Patients over the Age of 70 Years.Takehito Katoh, Iwao Kinoshita, Ken Nakagawa, Toshiki Matsubara, Shuga ...1986 Volume 26 Issue 1 Pages 47-56
Published: February 28, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThere were 29 patients with lung cancer over the age of 70 years (Group I) and 85 patients with lung cancer below the age of 70 years (Group II) who underwent pulmonary resection together with resection of neighboring organs in Cancer Institute Hospital from 1970 through 1983. The invasion to the neighboring organs was evidenced histologically (p3 and/or p-T3) in 26 patients among Group I and in 61 patients among Group II.
The survival curve of cases of p3 and/or p-T3 lung cancer of Group I, exclusive of cases of operative deaths or absolutely non-curative operations, was similar to that of Group II. The survival rate of cases of p3 and/or p-T3 lung cancer seemed to be influenced by lymph node metastasis, but not by histological type or the site of invasion of lung cancer.
The rates of operative deaths and postoperative complications, most of which were related to cardiorespiratory complications, in patients of Group I were higher than thatof Group II. Smoking and combined diseases were regarded as risk factors for postoperative cardiorespiratory complications.
We consider lobectomy with resection of involved organs as a basic procedure forp3 and/or p-T3 lung cancer, and upper mediastinal lymphnode dissection should be performed, if the patient's condition permits.View full abstractDownload PDF (1061K) -
Shugaku Oh, Takehito Katoh, Toshiki Matsubara, Ken Nakagawa, Iwao Kino ...1986 Volume 26 Issue 1 Pages 57-63
Published: February 28, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSEleven cases of peripheral lung cancer in which the diameter did not exceed 1.5cm were studied clinically.
Eight cases were detected by chest X-ray and 3 by symptoms.Histological findings showed squamous cell carcinoma in 6 cases, adenocarcinoma in 4 cases and carcinoid in one case.Out of 11 lesions, 2 were in the sub-segmental bronchi and 2 were in the sub-subsegmental bronchi and 7 were in more peripheral regions. Chest X-ray findings showed tumor shadow in 8 cases, secondary pneumonia in 2 cases and no abnormality (occult) in one case.
Lobectomy with mediastinal lymph node dissection was performed in all cases. Postoperatively, hilar lymph node metastasis was observed in one case and the mediastinal lymph node metastasis in one case.
No recurrence was observed in the non-metastatic cases. Preoperatively, in all cases, cancer cells or cancerous tissue specimens were obtained by the transbronchial brushing cytology or biopsy.In 6 of 7 lesions located in more peripheral bronchi than sub-sub-segmental bronchi, cancer cells were obtained by the transbronchial brushing cytology method.Therefore we concluded that transbronchial brushing cytology is the most reliable method for diagnosis in such peripheral type small lung cancers.View full abstractDownload PDF (5419K) -
small Cell Lung CancerTetsuya Hisada, Shoji Kudoh, Keiko Teratani, Kenji Uetake, Masakiyo Hi ...1986 Volume 26 Issue 1 Pages 65-71
Published: February 28, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSBronchial artery infusion (BAI) of 25mg of cisplatin was performed in 25 patients with primary non-small cell lung cancer. No severe side effects were observed after the procedure. No patients showed 50% or greater tumor reduction and only 3 patients showed 20% or greater tumor reduction at 2 weeks after BAI. The tumor reduction rate of this group was smaller than that of 47 cases treated with a combination of BAI of mitomycin C and systemic administration of vincristin (p<0.01). These results suggest that the infusion time, dosage and metabolism of cisplatin must be studied further before it can be used as a cytotoxic drug for BAI.View full abstractDownload PDF (700K) -
Yoichi Chijimatsu, Miyoji Aiba, Yasue Morikawa, Yoshiyuki Doi, Hiomi H ...1986 Volume 26 Issue 1 Pages 73-79
Published: February 28, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSOut of 368 cases of lung cancer during the last eight years, 35 cases of histologically proved lung cancer with onset of neurological symptoms were investigated. Hemiparesis was the most prevalent symptom, occurring in 14 cases. Various other kinds of neurological symptoms were recognized at the onset of the disease. Among 16 cases of solitary brain metastases, 15 cases underwent craniotomy, and 4 cases received lobectomy for primary lung cancer subsequently. It must be remembered that the first symptoms of lung cancer may be miscellaneous neurological symptoms, and in such cases multidisciplinary therapy, including craniotomy, should be contemplated.View full abstractDownload PDF (5475K) -
Heihachi Ishikawa, Ryoichi Sakakibara, Hiroshi Hosoda, Akira Syakato, ...1986 Volume 26 Issue 1 Pages 81-90
Published: February 28, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe diagnostic value of CT-guided needle aspiration biopsy (CT? NAB) was examined in 70 patients with intrathoracic tumor-like lesions (9 with mediastinal tumor-like lesions, 52 with intrapulmonary tumor-like lesions, 9 with pleural lesions).
In 68 out of 70 cases (97%), the needle penetrated the lesion. The overall accuracy was 96%(67 out of 70 cases). The true positive rate was 93%(39 out of 42 cases) and the true negative rate was 90%(28 out of 31). Complications developed in 16 cases (23%). CT·NAB method was especially suitable in 22 out of 70 cases and their lesions were classified into 9 patterns by roentgenogram.
Finally, we concluded that CT·NAB is a safe, easy and very efficient technique for diagnosing thoracic malignant lesions.View full abstractDownload PDF (8625K) -
Ikuhiro Nose, Toshihiko Koga, Kazuyuki Shimizu, Mieko Miyazaki, Yuko K ...1986 Volume 26 Issue 1 Pages 91-95
Published: February 28, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSNeuron specific enolase (NSE) has been recognized as a new tumor marker for neuroendocrine tumor and small cell carcinomas of the lung. We experienced 2 cases of small cell carcinomas of the lung with elevation of serum NSE while serum CEA was within the normal range. Furthermore serum NSE correlated well with tumor activity during chemotherapy.
In histochemical studies NSE was stained in one case that showed a level of serum NSE of 15.7ng/ml, but not in the other case with a serum level of 4.6ng/ml.View full abstractDownload PDF (6482K) -
Kohhei Yokoi, Tetsuro Kodama, Masaru Tsumuraya, Yukio Shimosato, Takes ...1986 Volume 26 Issue 1 Pages 97-102
Published: February 28, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA case of granular cell tumor which originated in the periphery of the left upperlobe of the lung was reported. The patient was a 48 year-old female, who was found to have an abnormal mass density in the left lung field on chest X-ray films several years previously. Left upper lobectomy was performed. The tumor was 3 cm in diameter and firm. Histologically tumor cells had cytoplasmic acidophilic granules which were PAS-positive after diastasedigestion and strongly positive for acid phosphatase activity. Ultrastructurally tumor cells also had a large number of the pleomorphic lysosomal granules. Immunohistochemically, tumor cells showed positive reaction with anti-S-100 protein antibody. Angulate bodies were found inthe stromal cells histologically and ultrastructurally. This is the second reported case of granular cell tumor of peripheral lung origin.View full abstractDownload PDF (8423K) -
1986 Volume 26 Issue 1 Pages 103-114
Published: February 28, 1986
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1904K)
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