Between 1978 and 1996, 123 patients (25 males, 98 females) with T4 papillary thyroid carcinoma and a mean age of 60 years received surgical treatment at the Kurume Universit Hospital. In this paper, the maximum size and invasive portion of these tumors were reviewed, and their influence on overall survival rate was analysed. The TNM classfication was adopted in this study. With respect to T categories, there were 101 T4a and 22 T4b patients. With respect to N categories 34 patients were at stage NO, 65 were Nla, and 24 were Nib. As for the maximum size of the primary tumor, tumors with a size of more than 2 cm but less than 3 cm were most frequent (28%). The recurrent laryngeal nerve was most frequently observed in vasion site of the primary tumor. The overall five- and ten-year survival rates as determined by the Kaplan-Meier method were both 91% over the entire series. With respect to the T categories, the five-and ten-year survival rates of T4a were both 90%, whereas those of T4b were both 96%. From the point of view of treatment modalities, subtotal and total thyroidectomy are preferable for T4 cases whose tumor size is greater than 4 cm. In addition, extended dissection may be necessary for cases wherethe tumor invades the larynx, carotid artery and/or jugular vein.
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