The larynx performs multiple complex functions including phonation, respiration, and deglutition. For precise regulation of these functions, a feedback mechanism involving sensory receptors in the larynx is indispensable. We investigated the morphological characteristics of the muscle spindles and sensory nerve endings in the larynx. In this paper, we present these results and discuss their roles in regulation of laryngeal functions. Muscle spindles were identified in all the intrinsic laryngeal muscles, except for the lateral cricoarytenoid muscle, by histological study of human larynges. They were relatively infrequent and compact in their diameters and numbers of intrafusal muscle fibers compared with those in other skeletal muscles. Transmission electron microscopic observation showed a varicose pattern of the sensory nerve endings on the intrafusal fibers. Also, some nerve endings penetrated into the fibers, suggesting potentially high sensitivity of the muscle spindles as mechanoreceptors. The sensory nerve endings on the laryngeal muscles showed a multiform pattern, consisting of free nerve ending, flower-like ending, spiral ending, and terminal buttons. They seemed to work as multimodal sensory receptors.
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